NCT02536677

Brief Summary

EMPACT is the first attempt to comprehensively evaluate the current emergency care of acute chest pain from a regional representative sample in China.Findings will allow new opportunities to facilitate the clinical quality improvements and ultimately reduce the mortality and health care burden in patients with acute chest pain. It also will help to establish a regional network and database for further research and performance improvement.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8,374

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2016

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 27, 2015

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 1, 2015

Completed
4 months until next milestone

Study Start

First participant enrolled

January 1, 2016

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2017

Completed
Last Updated

January 9, 2018

Status Verified

January 1, 2018

Enrollment Period

1.8 years

First QC Date

August 27, 2015

Last Update Submit

January 6, 2018

Conditions

Acute Chest PainAcute Coronary Syndrome

Keywords

Acute Chest PainAcute Coronary SyndromeEvaluation and ManagementDecision AidHealthcare Utilization

Outcome Measures

Primary Outcomes (1)

  • Major adverse cardiac events (MACE)

    The primary outcome was a composite of adjudicated MACEs, including death from all causes, non-fatal acute myocardial infarction (AMI), urgent revascularization, stroke, cardiac arrest, and cardiogenic shock.

    30 days after presenting to the emergency departments(ED)

Secondary Outcomes (1)

  • revisiting to ED and rehospitalization

    30 days after presenting to the EDs

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

We used a stratified random sampling design to generate a Shandong province representative sample of hospitals. Twenty two hospitals were randomly selected including 12 rural hospitals, 6 grade II and 4 grade III urban hospitals. One grade II-urban hospital refused to participate. As a coordinating center, Qilu Hospital of Shandong University participated in the study without being sampled. Finally, 22 hospitals were included. A total of more than 10000 patients were anticipated to be consecutively enrolled from the participating hospitals over the course of the 12-month program. The beginning dates of enrollment in 22 centers were distributed from January, 2016 to September 2016.

You may qualify if:

  • Eighteen years and older
  • Presenting to the ED
  • With acute chest pain or suspected ACS
  • Symptoms occurring within 24 hours
  • Informed consent from patient or next of kin

You may not qualify if:

  • Chest pain caused by trauma
  • Persisting or recurrent chest pain caused by rheumatic diseases or cancer
  • Transferred from another grade II or grade III hospital
  • Presenting to the ED again within 30 days after initial enrollment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Qilu Hospital of Shandong University

Jinan, Shandong, 250012, China

Location

Related Publications (3)

  • Cheng K, Zheng W, Wang J, Wu S, Zheng J, Sang W, Ma J, Pang J, Pan C, Wang G, Wu Y, Chen Y, Xu F. Incidence, management and outcomes of patients with acute chest pain presenting to the emergency departments in China: findings from a prospective multicentre registry. BMJ Open. 2025 Mar 27;15(3):e091085. doi: 10.1136/bmjopen-2024-091085.

    PMID: 40147987DERIVED

  • Yin X, Pan X, Zhang J, Wu S, Cui W, Wang Y, Li C, Wang J, Chen Y. Impact of admission glucose and 30-day major adverse cardiovascular events on patients with chest pain in an emergency setting: insights from the China EMPACT registry. Front Cardiovasc Med. 2024 Oct 9;11:1367704. doi: 10.3389/fcvm.2024.1367704. eCollection 2024.

    PMID: 39444552DERIVED

  • Zheng W, Wang J, Xu F, Zheng J, Zhang H, Ma J, Wang G, Wang H, Chew DP, Chen Y. Evaluation and management of patients with acute chest pain in China (EMPACT): protocol for a prospective, multicentre registry study. BMJ Open. 2018 Jan 23;8(1):e017872. doi: 10.1136/bmjopen-2017-017872.

    PMID: 29362251DERIVED

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular Diseases

Study Officials

  • Yuguo Chen, M.D., Ph.D

    Qilu Hospital of Shandong University

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Month
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
President, Chinese Society of Emergency Medicine;Director, Chest Pain Center, Qilu Hospital of Shandong University

Study Record Dates

First Submitted

August 27, 2015

First Posted

September 1, 2015

Study Start

January 1, 2016

Primary Completion

October 1, 2017

Study Completion

October 1, 2017

Last Updated

January 9, 2018

Record last verified: 2018-01

Locations

CN(1)