NCT05164601

Brief Summary

The MPCS-ACS Study (Multicenter Prospective Cohort Study on Acute Coronary Syndrome) is a comprehensive, forward-looking research project designed to evaluate the prognostic outcomes of patients diagnosed with acute coronary syndrome (ACS) who declined coronary artery bypass grafting (CABG) and underwent percutaneous coronary intervention (PCI) instead. Leveraging a multicenter approach, the study aims to collect data from a diverse patient population, thereby enhancing the generalizability and clinical relevance of its findings. Upon enrollment, detailed information is gathered, including demographic data, clinical history, and key biochemical markers. The study also documents the various medication regimens prescribed during hospitalization to assess their influence on patient outcomes. A key feature of MPCS-ACS is its rigorous follow-up protocol, which involves regularly monitoring patients after discharge to track recovery progress and the occurrence of any subsequent cardiovascular events. This methodical approach is designed to generate valuable insights into the long-term prognosis of ACS patients treated with PCI, ultimately contributing to the refinement of therapeutic strategies and improving the standard of care across all participating centers.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22,500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2016

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2016

Completed
2.4 years until next milestone

First Submitted

Initial submission to the registry

November 7, 2018

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2021

Completed
7 months until next milestone

First Posted

Study publicly available on registry

December 20, 2021

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
Last Updated

February 4, 2025

Status Verified

January 1, 2025

Enrollment Period

5 years

First QC Date

November 7, 2018

Last Update Submit

January 30, 2025

Conditions

Acute Coronary Syndrome

Keywords

Acute Coronary SyndromeAcute Myocardial Infarctioncoronary heart diseaseprognosis

Outcome Measures

Primary Outcomes (1)

  • Death

    All-cause mortality, Cardiac mortality

    10 years

Secondary Outcomes (7)

  • Major adverse cardiovascular events (MACE)

    10 years

  • Major adverse cardiovascular and cerebrovascular events (MACCE）

    10 years

  • revascularization of the target vesse

    10 years

  • episodes of unstable angina necessitating medical intervention

    10 years

  • hospitalization for acute heart failure classified as Killip Class IV

    10 years

  • +2 more secondary outcomes

Study Arms (1)

AMI Patients Cohort

Other: No Intervention - Observational Only

Interventions

No Intervention - Observational OnlyOTHER

Clinical Follow-Up

AMI Patients Cohort

Eligibility Criteria

Age18 Years - 79 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Acute Coronary Syndrome

You may qualify if:

  • Men and women aged between 18 and 79 years.
  • Patients diagnosed with Acute Coronary Syndrome (ACS), including Unstable Angina (UA) and Acute Myocardial Infarction (AMI), based on typical clinical symptoms, changes in electrocardiographic (ECG) readings, and elevated cardiac biomarkers.
  • Patients who underwent coronary angiography confirming coronary artery stenosis and opted for PCI treatment instead of coronary artery bypass grafting (CABG).
  • Patients who are under long-term follow-up.

You may not qualify if:

  • Patients with rheumatic heart disease, valvular heart disease, or congenital heart disease.
  • Patients with malignant tumors or hematologic diseases.
  • Patients with severe liver or kidney dysfunction or pulmonary heart disease.
  • Patients with a life expectancy of less than one year due to terminal illnesses such as advanced cancer or chronic kidney disease requiring dialysis.
  • Patients whose health is severely impacted by acute infections.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, 630000, China

Location

The First Affiliated Hospital of Xinjiang Medicial University

Ürümqi, Xinjiang, 830000, China

Location

MeSH Terms

Conditions

Acute Coronary SyndromeCoronary Disease

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular Diseases

Study Officials

  • Xiang Xie, PhD

    Xinjiang Medical University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
7 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Head of Hypertension Department, Clinical Professor

Study Record Dates

First Submitted

November 7, 2018

First Posted

December 20, 2021

Study Start

June 1, 2016

Primary Completion

May 31, 2021

Study Completion

December 31, 2023

Last Updated

February 4, 2025

Record last verified: 2025-01

Data Sharing

IPD Sharing
Will not share

Locations

CN(2)