Better Evaluation of Acute Chest Pain With Computed Tomography Angiography
BEACON
1 other identifier
interventional
500
1 country
1
Brief Summary
The purpose of this study is to determine whether cardiac CT can improve triage of acute chest pain patients in the emergency department.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2011
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2011
CompletedFirst Submitted
Initial submission to the registry
August 9, 2011
CompletedFirst Posted
Study publicly available on registry
August 10, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2015
CompletedAugust 4, 2016
August 1, 2016
2.6 years
August 9, 2011
August 3, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Successful discharge rate
The proportion of patients discharged home without major adverse events during the following 30 days. Major adverse events are cardiovascular death or non-fatal myocardial infarction.
30 days
Diagnostic yield of invasive angiography
Number of patients identified with severe coronary artery disease identified by invasive angiography requiring revascularisation according to the international guidelines.
30 days
Secondary Outcomes (8)
Successful discharge rate for all adverse events
30 days
Major adverse events
6 months
Acute coronary syndrome
Index hospital visit
Missed myocardial infarctions
2 days
Duration of hospital stay
Index hospital visit
- +3 more secondary outcomes
Study Arms (2)
Cardiac CT
ACTIVE COMPARATORTriage based on cardiac CT results.
Standard Care
NO INTERVENTIONStandard diagnostic management according to the European guidelines.
Interventions
Eligibility Criteria
You may qualify if:
- Acute chest pain or equivalent
- Patients older than 30 years
- Males \< 75 years and Females \< 80 years
You may not qualify if:
- STEMI
- Troponin \> 0.1
- History of known myocardial infarction, PCI or CABG
- Pregnancy
- Contrast allergy
- Renal disfunction
- No informed consent possible
- No follow-up possible
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Erasmus MC
Rotterdam, Netherlands
Related Publications (1)
Dedic A, Lubbers MM, Schaap J, Lammers J, Lamfers EJ, Rensing BJ, Braam RL, Nathoe HM, Post JC, Nielen T, Beelen D, le Cocq d'Armandville MC, Rood PP, Schultz CJ, Moelker A, Ouhlous M, Boersma E, Nieman K. Coronary CT Angiography for Suspected ACS in the Era of High-Sensitivity Troponins: Randomized Multicenter Study. J Am Coll Cardiol. 2016 Jan 5;67(1):16-26. doi: 10.1016/j.jacc.2015.10.045.
PMID: 26764061DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Koen Nieman, MD, PhD
Erasmus Medical Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate professor
Study Record Dates
First Submitted
August 9, 2011
First Posted
August 10, 2011
Study Start
July 1, 2011
Primary Completion
February 1, 2014
Study Completion
February 1, 2015
Last Updated
August 4, 2016
Record last verified: 2016-08
Data Sharing
- IPD Sharing
- Will not share