NCT02509936

Brief Summary

This study seeks to evaluate the impact of an intensive home-based education intervention targeting severely stunted Guatemalan children for catch up growth and improved development. Half of the children in the study will receive standard of care, which includes micronutrient supplementation and a food ration. The other half of children in the study will receive, in addition to the above, home-based dietary assessment and individualized parental nutrition education.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
324

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2015

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 17, 2015

Completed
11 days until next milestone

First Posted

Study publicly available on registry

July 28, 2015

Completed
4 days until next milestone

Study Start

First participant enrolled

August 1, 2015

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2016

Completed
3.2 years until next milestone

Results Posted

Study results publicly available

November 26, 2019

Completed
Last Updated

November 26, 2019

Status Verified

November 1, 2019

Enrollment Period

1.2 years

First QC Date

July 17, 2015

Results QC Date

August 19, 2019

Last Update Submit

November 6, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Height/Length for Age Z Score

    Change in height/length over 6 months. Tool used is the WHO Child Growth Reference Standards. Change values calculated as: 6 month (z-score) minus Baseline (z-score).

    Baseline, 6 months

Secondary Outcomes (9)

  • Cognitive Development

    Baseline, 6 months

  • Socioemotional Development

    Baseline, 6 months

  • Gross Motor Development

    Baseline, 6 months

  • Fine Motor Development

    Baseline, 6 months

  • Receptive Language Development

    Baseline, 6 months

  • +4 more secondary outcomes

Study Arms (2)

Standard of Care Arm

ACTIVE COMPARATOR

In this arm enrolled children will receive the national standard of care for growth support, which includes growth monitoring, a food ration, and a multiple micronutrient powder supplement.

Dietary Supplement: Standard-of-care nutrition support

Home-based Education

EXPERIMENTAL

In the intervention arm, children will receive the national standard of care for growth support, which includes growth monitoring, a food ration, and a multiple micronutrient powder supplement. In addition, they will receive monthly home visits from a community health promoter who will provide detailed dietary assessments and individualized dietary coaching and education to parents.

Behavioral: Home-based nutrition educationDietary Supplement: Standard-of-care nutrition support

Interventions

Health promoters will use 24-hour dietary recall information to assess meal frequency and dietary diversity and then provide tailored nutrition coaching to parents.

Home-based Education

Subjects will be provided with a standard food ration and with a multiple micronutrient powder dietary supplement (Chispitas)

Home-based EducationStandard of Care Arm

Eligibility Criteria

Age6 Months - 24 Months
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Child aged 6-24 months at time of enrollment
  • Height/length for age Z score of less than -2.5
  • Child lives with parent/legal guardian

You may not qualify if:

  • Presence of acute malnutrition (weight for length/height Z score of less than -2)
  • Presence of other severe medical illness (e.g. congenital heart disease, genetic abnormality)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Wuqu' Kawoq

Tecpán Guatemala, Departamento de Chimaltenango, Guatemala

Location

Related Publications (2)

  • Martinez B, Cardona S, Rodas P, Lubina M, Gonzalez A, Farley Webb M, Grazioso MDP, Rohloff P. Developmental outcomes of an individualised complementary feeding intervention for stunted children: a substudy from a larger randomised controlled trial in Guatemala. BMJ Paediatr Open. 2018 Oct 3;2(1):e000314. doi: 10.1136/bmjpo-2018-000314. eCollection 2018.

  • Martinez B, Webb MF, Gonzalez A, Douglas K, Grazioso MDP, Rohloff P. Complementary feeding intervention on stunted Guatemalan children: a randomised controlled trial. BMJ Paediatr Open. 2018 Apr 27;2(1):e000213. doi: 10.1136/bmjpo-2017-000213. eCollection 2018.

MeSH Terms

Conditions

MalnutritionDevelopmental Disabilities

Condition Hierarchy (Ancestors)

Nutrition DisordersNutritional and Metabolic DiseasesNeurodevelopmental DisordersMental Disorders

Results Point of Contact

Title
Dr Peter Rohloff
Organization
Wuqu' Kawoq | Maya Health Alliance

Study Officials

  • Peter Rohloff, MD PhD

    Wuqu' Kawoq

    PRINCIPAL INVESTIGATOR
  • Maria Grazioso, PhD

    Universidad del Valle, Guatemala

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 17, 2015

First Posted

July 28, 2015

Study Start

August 1, 2015

Primary Completion

October 1, 2016

Study Completion

October 1, 2016

Last Updated

November 26, 2019

Results First Posted

November 26, 2019

Record last verified: 2019-11

Locations