The Effect of Dairy and Non-dairy Alternatives on Satiety and Post-meal Glycemia in Healthy Young Adults

NCT02491814 | Completed Phase 1

• 1 other identifier: DFC_31012
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the effects of commercially-available dairy (1% cow's milk and yogurt beverage) and non-dairy alternatives (almond and soy beverages) on satiety and post-meal blood glucose. Each participant will receive every treatment in this crossover design study.

Conditions

Diabetes; Obesity

Keywords

Dairy; Breakfast cereal; Postprandial Glycemia; Satiety; Food Intake; Milk; Yogurt; Soy; Almond

Outcome Measures

Primary Outcomes (2)

• Blood Glucose

  Blood glucose (mmol/L) is measured using finger prick capillary blood samples

  0-170 minutes

• Subjective Appetite

  Subjective appetite ratings are obtained from four 100 mm visual analogue scale (VAS) questions assessing "Desire to Eat", "Hunger", "Fullness" and "Prospective Food Consumption". The average of all four VAS is calculated to obtain the average appetite score for statistical analysis

  0-170 minutes

Secondary Outcomes (2)

• Insulin

  0-170 minutes

• Food Intake

  120-140 minutes

Study Arms (5)

1% M.F. Milk and Breakfast Cereal

EXPERIMENTAL

Breakfast meal: 250 ml 1% M.F. Milk, 54 g Cheerios breakfast cereal, 100 mL water

Other: 1% M.F. Milk; Other: Breakfast cereal

Yogurt Beverage and Breakfast Cereal

EXPERIMENTAL

Breakfast meal: 250 ml Yogurt Beverage, 54 g Cheerios breakfast cereal, 100 mL water

Other: Yogurt Beverage; Other: Breakfast cereal

Soy Beverage and Breakfast Cereal

EXPERIMENTAL

Breakfast meal: 250 ml Soy Beverage, 54 g Cheerios breakfast cereal, 100 mL water

Other: Soy Beverage; Other: Breakfast cereal

Almond Beverage and Breakfast Cereal

EXPERIMENTAL

Breakfast meal: 250 ml Almond Beverage, 54 g Cheerios breakfast cereal, 100 mL water

Other: Almond Beverage; Other: Breakfast cereal

Water (control) and Breakfast Cereal

EXPERIMENTAL

Breakfast meal: 250 ml Water, 54 g Cheerios breakfast cereal, 100 mL water

Other: Water; Other: Breakfast cereal

Interventions

1% M.F. Milk OTHER

Also known as: 1% cow's milk, Neilsen Canada

1% M.F. Milk and Breakfast Cereal

Yogurt Beverage OTHER

Also known as: Yop (Vanilla), General Mills

Yogurt Beverage and Breakfast Cereal

Soy Beverage OTHER

Also known as: Soy Milk, Silk Organic Original

Soy Beverage and Breakfast Cereal

Almond Beverage OTHER

Also known as: Almond Milk, Silk Original

Almond Beverage and Breakfast Cereal

Water OTHER

Also known as: Calorie-free control

Water (control) and Breakfast Cereal

Breakfast cereal OTHER

Also known as: Cheerios, General Mills

1% M.F. Milk and Breakfast Cereal; Almond Beverage and Breakfast Cereal; Soy Beverage and Breakfast Cereal; Water (control) and Breakfast Cereal; Yogurt Beverage and Breakfast Cereal

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy BMI (20.0 - 24.9 kg/m2)
• Females with regular monthly menstrual cycles

You may not qualify if:

• Diabetes
• Fasting blood glucose higher than 5.8 mmol/L
• Pregnancy
• Medications
• Smoking
• Lactose intolerance or allergies to milk, soy, or almonds
• Elite athletes
• Those trying to lose or gain weight
• Breakfast skippers and those on an energy-restricted diet
• Score equal to or higher than 11 on Eating Habits Questionnaire

Sponsors & Collaborators

• University of Toronto: lead
• Dairy Farmers of Canada: collaborator

Study Sites (1)

Department of Nutritional Sciences, FitzGerald Building

Toronto, Ontario, M5S 3E2, Canada

Location

MeSH Terms

Conditions

Diabetes Mellitus; Obesity

Interventions

Milk; Soy Milk; Water

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Dairy Products; Food; Food and Beverages; Milk Substitutes; Soy Foods; Vegetable Products; Vegetables; Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Officials

• G. Harvey Anderson, Ph.D.

  Department of Nutritional Sciences, University of Toronto

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 27, 2015
• First Posted: July 8, 2015
• Study Start: January 1, 2015
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: May 12, 2016

Record last verified: 2016-05

Locations

CA (1)