Glycemic Response of Co-ingesting Carbohydrate and Amino Acids

NCT02455765 | Completed

• 1 other identifier: 2014/00366
• Study Type: interventional
• Target: 23
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).

Conditions

Metabolic Diseases

Outcome Measures

Primary Outcomes (2)

• Glycemic response

  Blood glucose will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min

  210 minutes post consumption of carbohydrate

• Insulinemic response

  Plasma insulin will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min

  210 minutes post consumption of carbohydrate

Study Arms (7)

White rice control

EXPERIMENTAL

Subjects will consume white rice as control (50g carbohydrate)

Other: Rice and Amino Acid mixtures

co-ingest low dose of amino acid

EXPERIMENTAL

Subjects will receive 68 ml of amino acid mixture together with white rice

Other: Rice and Amino Acid mixtures

co-ingest high dose of amino acid

EXPERIMENTAL

Subjects will receive 136 ml of amino acid mixture together with white rice

Other: Rice and Amino Acid mixtures

pre-load low dose15 min

EXPERIMENTAL

Subjects will receive 68 ml of amino acid mixture 15 min before consumption of white rice

Other: Rice and Amino Acid mixtures

pre-load low dose 30 min

EXPERIMENTAL

Subjects will receive 68 ml of amino acid mixture 30 min before consumption of white rice

Other: Rice and Amino Acid mixtures

pre-load high dose 15 min

EXPERIMENTAL

Subjects will receive 136 ml of amino acid mixture 15 min before consumption of white rice

Other: Rice and Amino Acid mixtures

pre-load high dose 30 min

EXPERIMENTAL

Subjects will receive 136 ml of amino acid mixture 30 min before consumption of white rice

Other: Rice and Amino Acid mixtures

Interventions

Rice and Amino Acid mixtures OTHER

Rice and amino acid mixture

White rice control; co-ingest high dose of amino acid; co-ingest low dose of amino acid; pre-load high dose 15 min; pre-load high dose 30 min; pre-load low dose 30 min; pre-load low dose15 min

Eligibility Criteria

• Age: 21 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male
• Chinese ethnicity
• Age between 21-50 years
• Body mass index (BMI) between 18-24.9 kg/m2
• Waist circumference ≤ 90 cm for men
• Normal blood pressure (\<120/80 mmHg)
• Fasting blood glucose \< 6 mmol/L

You may not qualify if:

• dislike the consumption of Essence of Chicken
• participating in competitive sports
• allergic to amino acids and rice
• metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)
• Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency
• on prescription medication
• smokers

Sponsors & Collaborators

• Singapore Institute of Food and Biotechnology Innovation: lead
• Cerebos Asia Pacific Pte Ltd: collaborator

MeSH Terms

Conditions

Metabolic Diseases

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 21, 2015
• First Posted: May 28, 2015
• Study Start: June 1, 2014
• Primary Completion: October 1, 2015
• Study Completion: October 1, 2015
• Last Updated: January 28, 2016

Record last verified: 2016-01