The Metabolic Effects of Consuming Carbohydrate With Different Protein Types

NCT02380846 | Completed

• 1 other identifier: 2013/00589
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to find out how consuming different proteins with rice affect metabolism. Most meals the investigators eat predominantly consist of a carbohydrate and protein (i.e. rice, noodles, bread etc with meats or seafood). However, it is still unknown how consuming different proteins with commonly eaten carbohydrates affect metabolism. Previous studies have shown that proteins stimulate hormones such as insulin, glucagon and gut hormones. However, the extent of the response depends on protein type. The metabolic responses to carbohydrates have also been shown to be greatly affected when they are eaten with proteins. However, most of the previous studies have used glucose as the carbohydrate and it is still unknown how eating proteins with carbohydrate foods such as rice affect metabolism. Therefore, this study has been initiated to determine the metabolic effects of eating different protein types with rice. Using the most common carbohydrate eaten in Asia (rice) and four commonly eaten protein foods (egg, chicken, fish and beancurd), this study aims to observe the metabolic effects of co-ingesting proteins and carbohydrate. The resulting data will provide valuable insights into the metabolic effects of protein-carbohydrate meals and will be useful in the development of practical advice and dietary guidelines for those with chronic diseases (such as diabetes and obesity).

Conditions

Metabolic Diseases

Outcome Measures

Primary Outcomes (3)

• Blood glucose response (incremental area under the curve) measured using the hemocue

  Blood glucose response (incremental area under the curve) measured using the hemocue

  3.5 hours post consumption

• Insulin (incremental area under the curve) is determined using the COBAS

  Insulin (incremental area under the curve) is determined using the COBAS

  3.5 hours post consumption

• Glucagon determined using the ELISA

  Glucagon is determined using the ELISA

  3.5 hours post consumption

Secondary Outcomes (2)

• Effects of physical activity

  Assessed at the start of every test session 1-2 weekly and up to 8 weeks in total per subject.

• Satiety: Hunger and fullness measured using the Visual analogue scale

  Assessed at the start of every test session 1-2 weekly and up to 8 weeks in total per subject.

Study Arms (5)

Rice

OTHER

Control session - white rice (equivalent to 50g available carbohydrates)

Other: White rice

Rice with chicken

ACTIVE COMPARATOR

Treatment 1 - White rice and steamed chicken breast (25g protein)

Other: Rice with chicken breast

Rice with fish

ACTIVE COMPARATOR

Treatment 2 - White rice and steamed fish (25g protein)

Other: Rice with fish

Rice with egg white

ACTIVE COMPARATOR

Treatment 3 - White rice and egg white (25g protein)

Other: Rice with egg white

Rice with beancurd

ACTIVE COMPARATOR

Treatment 4 - White rice and steamed beancurd (25g protein)

Other: Rice with beancurd

Interventions

White rice OTHER

Control - white rice

Rice

Rice with chicken breast OTHER

Treatment 1 - steamed white rice with steamed chicken breast

Rice with chicken

Rice with fish OTHER

Treatment 2 - steamed white rice with steamed fish

Rice with fish

Rice with egg white OTHER

Treatment 3 - steamed white rice with egg white

Rice with egg white

Rice with beancurd OTHER

Treatment 4 - steamed white rice with steamed beancurd

Rice with beancurd

Eligibility Criteria

• Age: 21 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Chinese ethnicity
• Male
• Age between 21-40 years
• Do not have any metabolic diseases (diabetes, hypertension etc)
• Do not have G6PD deficiency
• Not on prescription medication known to affect glucose related metabolism
• Not allergic/intolerant to any of the test foods
• Do not partake in sports at the competitive and/or endurance levels
• Weight of at least 45kg
• Body mass index between 18.0 to 24.9 kg/m2
• Normal blood pressure (120/80 mmHg)
• Fasting blood glucose \<6.0 mmol/L

Sponsors & Collaborators

• Singapore Institute of Food and Biotechnology Innovation: lead

MeSH Terms

Conditions

Metabolic Diseases

Interventions

In Situ Hybridization, Fluorescence; Egg White

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

In Situ Hybridization; Staining and Labeling; Histocytological Preparation Techniques; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Histological Techniques; Investigative Techniques; Cytogenetic Analysis; Genetic Techniques; Nucleic Acid Hybridization; Eggs; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 28, 2015
• First Posted: March 5, 2015
• Study Start: September 1, 2013
• Primary Completion: October 8, 2018
• Study Completion: October 8, 2018
• Last Updated: May 15, 2019

Record last verified: 2019-05