Use of the DBS for the Follow-up of Blood Clinical Parameters of Old People

NCT02440945 | Terminated

• 1 other identifier: 9114
• Study Type: interventional
• Target: 129
• Locations: 1 country
• Sites: 1

Brief Summary

It is about an interventional study.The use of the blotting paper called "Dried Blood Spot" or DBS is a method of systematic neonatal screening of the metabolic diseases. Indeed, it has multiple interests: realized thanks to lancets, it is much less invasive than a classic blood collection. Besides, the transport of the blood sampling is facilitated because most of the analysts are stable on DBS at room temperature one week or more. Finally the use of this DM reduces the infectious risks bound to the manipulation of the blood sampling and to the inactivation of microorganisms. The moderate results are vitamin D, albumin, prealbumin, CRP, orosomucoide The DBS presents a major interest for the care of the old and fragile people who have on one hand a low peripheral venous capital and on the other hand for whom the possibility of a dosage on DBS will allow a facilitated biological follow-up. Indeed it is very important to detect as soon as possible the most fragile old people, those who have the biggest risk of seeing their health degrading during a physical, psychic or social stress, to concentrate the efforts of coverage and limit these risks. The advantage of the biological criteria is the speed of the test making (a blood test), in the absence of necessity of active participation by the patient (the clinical criteria require to test the patient in the walking, to test its muscular strength, etc.) and in the saving of time diagnosis for the clinician. The blood biological markers of the fragility are essentially the rate of 25OH vitamin D, the markers of undernutrition (albumin, prealbumin) and of the inflammation (CRP, orosomucoïde). These last four parameters are now measurable from the DBS thanks to the quantitative mass spectrometry.

Conditions

Metabolic Diseases

Outcome Measures

Primary Outcomes (1)

• Use of the DBS for the follow-up of blood clinical parameters of the old people

  The moderate results are vitamin D, albumin, Prealbumin, CRP, Prealbumin, orosomucoide CRP, Orosomucoide

  36 months

Study Arms (1)

collection of blood

EXPERIMENTAL

160 old people for the collection of blood

Device: Collection of blood

Interventions

Collection of blood DEVICE

Blood test on blotting paper DBS (for the patients recruting)

collection of blood

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Man / woman
• Having a standard blood test planned during their consultation or their hospitalization in the service of Geriatrics of Pr C. Jeandel
• Signature of the informed consent by the patient

You may not qualify if:

• Absence of signed informed consent
• Patients with cutaneous disorders which increase the risks caused by the blood test (cutaneous infection)

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

CHRU

Montpellier, 34295, France

Location

Related Publications (1)

• Tall ML, Lehmann S, Diouf E, Gerard C, Filali S, Gabelle A, Hirtz C, Gabert L, Sauvinet V, Pirot F, Pivot C. [Injectable preparation of labeled leucine with the carbon 13 for a clinical research program on the Alzheimer disease: pharmaceutical control of raw materials and the finished product and stability study]. Ann Pharm Fr. 2015 Jan;73(1):43-59. doi: 10.1016/j.pharma.2014.06.002. Epub 2014 Jul 11. French.

  PMID: 25577016 BACKGROUND

MeSH Terms

Conditions

Metabolic Diseases

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Study Officials

• Sylvain lehmann, PU-PH

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2015
• First Posted: May 12, 2015
• Study Start: October 16, 2013
• Primary Completion: October 16, 2015
• Study Completion: October 16, 2015
• Last Updated: December 29, 2021

Record last verified: 2021-12

Locations

FR (1)