Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus)

NCT02423954 | Terminated Phase 1

• 1 other identifier: WG2015001
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Determine Phase 2 dose of study drug

Conditions

Advanced Cancer; Pancreatic Cancer; Renal Cell Cancer; Non Small Cell Lung Cancer; Colorectal Carcinoma; Endometrial; Uterine

Outcome Measures

Primary Outcomes (1)

• The recommended phase 2 dose (RP2D) of chemotherapy in combination with nivolumab in subjects with advanced cancer.

  phase 2 dosing of nivolumab + chemotherapy

  up to 4 weeks

Secondary Outcomes (4)

• Frequency of grade 3 or higher treatment-related adverse events by CTCAE 4.03

  up to 12 months

• Response rate by irRC and response evaluation criteria in solid tumors (RECIST) 1.1 criteria1,2

  12 weeks

• The overall survival (OS) and progression-free survival (PFS)

  up to 12 months

• Quantify changes in amount of blood proteins and circulating tumor DNA in patients enrolled on this study

  up to 12 months

Study Arms (3)

Arm 1

EXPERIMENTAL

Temsirolimus 25 mg every 14 days + nivolumab

Drug: Temsirolimus; Drug: nivolumab

Arm 2

EXPERIMENTAL

Irinotecan 150 mg/m2 every 14 days + nivolumab

Drug: Irinotecan; Drug: nivolumab

Arm 3

EXPERIMENTAL

Irinotecan + capecitabine + nivolumab irinotecan 175 mg/m2 on day 1 every 14 days + capecitabine 1000 mg PO BID days 1-5 on, days 6-7 off, each 7 day period

Drug: Irinotecan + capecitabine; Drug: nivolumab

Interventions

Temsirolimus DRUG

Also known as: Torisel

Arm 1

Irinotecan DRUG

Also known as: Camptosar

Arm 2

Irinotecan + capecitabine DRUG

Also known as: Camptosar + Xeloda

Arm 3

nivolumab DRUG

Also known as: Opdivo

Arm 1; Arm 2; Arm 3

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient at least 18 years old and has definitive histologically or cytologically confirmed metastatic solid tumor.
• Patient has one or more metastatic tumors measurable by CT scan (or PET/CT, if patient is allergic to CT contrast media). Tumor sites that are considered measureable must not have received prior radiation therapy. For metastatic tumors not measurable by CT and/or PET/CT, there needs to be tumor measuring at least 1cm in one dimension by digital calipers on physical exam.
• Patients can be enrolled only on one of the treatment arms on this trial.
• The investigator will select the appropriate treatment arm for the patient with the following requirements: (a) Patients cannot have had prior progression or intolerance on the single agent chemotherapy and then enrolled on an arm with that same single agent chemotherapy plus nivolumab (b) The chemotherapy on the arm selected must be considered standard of care or its components listed in the NCCN guidelines (www.nccn.org) for that cancer type.
• Have recovered from acute toxicities of prior treatment:
• \> 3 weeks must have elapsed since receiving any investigational agent.
• \> 2 weeks must have elapsed since receiving any radiotherapy, or ≥ 3 weeks or 5 half-lives whichever is shorter for treatment with cytotoxic or biologic agents ( ≥ 6 weeks for mitomycin or nitrosoureas). Chronic treatment with non-investigational gonadotropin-releasing hormone analogs or other hormonal or supportive care is permitted.
• Patient has adequate biological parameters as demonstrated by the following blood counts at time of screening:
• Absolute neutrophil count (ANC) \> 1500 mm3, platelet count ≥ 100×109 L, hemoglobin ≥ 9 g/dL. Subject can be given packed red blood cell transfusion
• Calculated creatinine clearance \> 40 ml/min by Cockroft-Gault equation:
• \[CreatClear = Sex \* ((140 - Age) / (SerumCreat)) \* (Weight / 72); where Sex = 1 for men and 0.85 for women\], total bilirubin 1.5 times the upper limit of normal (ULN) range, AST/ALT ≤ 3 times the upper limit of normal (ULN) range.
• Thyroid stimulating hormone (TSH) within institutional normal limits. If TSH is above the upper limit of normal range, then a free T4 within institutional normal limits is acceptable. If thyroid replacement therapy is initiated then patient may be screened and enrolled once the above criterion is met.
• Persistent prior systemic therapy non-hematologic AE grade ≤ 2 (except alopecia or correctable electrolyte abnormality with supplementation)
• Patient has a Karnofsky performance status (KPS) ≥ 70.
• Women of child-bearing potential (i.e., women who are pre-menopausal or not surgically sterile) must be willing to use an acceptable contraceptive method (abstinence, oral contraceptive or double barrier method) for the duration of the study and for 5 months following the last dose of nivolumab and 30 days following the last dose of chemotherapy on this trial on this trial, and must have a negative urine or serum pregnancy test within 2 weeks prior to beginning treatment on this trial. If a female subject or female partner of a male subject becomes pregnant during this period then patient will be recommended to seek appropriate obstetric care. The study will not be monitoring subjects or female partners of subjects for pregnancy after the last dose of study drug or chemotherapy.

You may not qualify if:

• Active clinically serious infection \> CTCAE (version 4.03) Grade 2.
• Serious non-healing wound, ulcer, or bone fracture.
• Patient has known brain metastases. Baseline imaging of the brain is required within 28 days prior to randomization.
• Prior therapy with a mammalian target of rapamycin (mTOR) inhibitor for the RCC subjects, prior therapy with irinotecan or topotecan for NSCLC subjects, and prior therapy with irinotecan for CRC patients.
• Inability to complete informed consent process and adhere to the protocol treatment plan and follow-up requirements.
• Patient has known active infection with HIV, hepatitis B, or hepatitis C (patients are NOT required to be tested for the presence of such viruses prior to therapy on this protocol).
• Requiring daily corticosteroid dose ≥ 10 mg prednisone or equivalent per day.
• Patient has undergone major surgery, other than diagnostic surgery (e.g., surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to Day 1 of treatment in this study.
• Patient has serious medical risk factors involving any of the major organ systems, or serious psychiatric disorders, which could compromise the patient's safety or the study data integrity.
• Patient will be receiving any other anti-cancer therapy during participation in this trial.
• Prior treatment with nivolumab is not allowed. Prior receipt of other PD-1 inhibitors or PD-L1 inhibitors is allowed.
• Active or prior documented autoimmune disease requiring systemic treatment within the past 2 years.

Sponsors & Collaborators

• Western Regional Medical Center: lead

Study Sites (1)

Cancer Treatment Center of America @ Western Regional Medical Center

Goodyear, Arizona, 85338, United States

Location

MeSH Terms

Conditions

Pancreatic Neoplasms; Carcinoma, Renal Cell; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms

Interventions

temsirolimus; Irinotecan; Capecitabine; Nivolumab

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Kidney Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Lung Diseases; Respiratory Tract Diseases; Intestinal Neoplasms; Gastrointestinal Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Intervention Hierarchy (Ancestors)

Camptothecin; Alkaloids; Heterocyclic Compounds; Deoxycytidine; Cytidine; Pyrimidine Nucleosides; Pyrimidines; Heterocyclic Compounds, 1-Ring; Fluorouracil; Uracil; Pyrimidinones; Deoxyribonucleosides; Nucleosides; Nucleic Acids, Nucleotides, and Nucleosides; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Serum Globulins; Globulins

Study Officials

• Jordan Waypa, MSN, FNP

  Western Regional Medical Center

  STUDY DIRECTOR

• Cynthia Lynch, MD

  Western Regional Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2015
• First Posted: April 22, 2015
• Study Start: April 1, 2015
• Primary Completion: November 1, 2017
• Study Completion: November 1, 2017
• Last Updated: July 2, 2018

Record last verified: 2018-06

Locations

US (1)