Characterization of the Motivational Deficit in Schizophrenia and Depression

NCT02378818 | Unknown

• 1 other identifier: D14-P012
• Study Type: interventional
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

This research focuses on disorders of motivation, responsible for a disability that patients experience daily. It is a disorder that affects behavior, especially social. Mechanisms, which result in these disorders, are poorly understood. This ignorance is responsible for the lack of effective therapy. The investigators realize this work in order to better understand the motivational deficits. The objective of the study is to characterize the cognitive mechanisms of motivational deficits in schizophrenia and depression. To answer the question posed in the research, it is planned to include 35 people with schizophrenia, 35 people with depression and 70 heathy volunteers in the Hospital of Sainte-Anne .

Conditions

Schizophrenia; Depression

Keywords

Schizophrenia; Negative symptoms; Lack of motivation; Cognitive characterization; Computational psychiatry; Depression

Outcome Measures

Primary Outcomes (2)

• level of force produced based in incentive reward

  the first inclusion day

• level of force produced based in incentive reward

  up to third day

Secondary Outcomes (3)

• consistent level of choice questionnaire

  the first inclusion day

• The proportion of choosing the expensive option (great effort/big time/immediate effort)

  the first inclusion day

• The proportion of corrects choice

  the first inclusion day

Study Arms (4)

Schizophrenia patients

OTHER

35 patients, Age between 18 and 65 years, with a diagnosis of schizophrenia and unchanged psychotropic treatment for at least three months before inclusion.

Behavioral: Force task, preference task, discount task, learning task.

Healthy volunteers (schizophrenia)

OTHER

35 healthy volunteers

Behavioral: Force task, preference task, discount task, learning task.

Depressive patients

OTHER

Behavioral: Force task, preference task, discount task, learning task.

Healthy volunteers (depression)

OTHER

Behavioral: Force task, preference task, discount task, learning task.

Interventions

Force task, preference task, discount task, learning task. BEHAVIORAL

Force task, preference task, discount task, learning task.

Depressive patients; Healthy volunteers (depression); Healthy volunteers (schizophrenia); Schizophrenia patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients :
• Age between 18 and 65 years
• Affiliation to a healthy insurance
• Subjects who were informed and willing to sign the form of free and informed consent and information of the curator if necessary (or consent of the tutor)
• French native tongue
• Diagnosis of schizophrenia according to ICD-10, made by a psychiatrist. The subjects are stabilized (less than three items include a score\> = 4 or to the positive level (P) of the PANSS)
• Healthy volunteers:
• Age between 18 and 65 years
• Affiliation to a healthy insurance
• Subjects who were informed and willing to sign the form of free and informed consent and information curator appropriate
• French native tongue

You may not qualify if:

• Patients:
• Unable major, persons deprived of liberty, pregnant women
• Enforced hospitalisation
• Recent abuse (1 week) or chronic use of addictive substances, except tobacco
• Treatment electro-convulsivo-therapy in the last 6 months
• Degenerative Pathology, neurological disorder
• Co-occurrence of a major depressive episode in a schizophrenic patient evaluated by a score\> 10 CDS
• Difficulty in understanding and expression in French language
• Deficit of visual acuity or uncorrected hearing
• Healthy volunteers:
• Unable major, persons deprived of liberty, pregnant women
• Current psychiatric disease
• Psychotropic treatment
• Recent abuse (1 week) or chronic use of addictive substances, except tobacco
• Difficulty in understanding and expression in French language

Sponsors & Collaborators

• Centre Hospitalier St Anne: lead
• Institut du Cerveau et de la Moelle (ICM Institute): collaborator

Study Sites (1)

Centre Hospitalier Sainte Anne

Paris, 75014, France

RECRUITING

MeSH Terms

Conditions

Schizophrenia; Depression

Interventions

Advisory Committees

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Policy Making; Social Control, Formal; Health Care Economics and Organizations

Study Officials

• Raphaël GAILLARD, MD, PhD

  Centre Hospitalier St Anne

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Raphaël GAILLARD, MD, PhD

CONTACT

00 33 1 45 65 81 54; r.gaillard@ch-sainte-anne.fr

Marie GODARD

CONTACT

+ 33 1 45 65 77 28; m.godard@ch-sainte-anne.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 13, 2014
• First Posted: March 4, 2015
• Study Start: November 21, 2014
• Primary Completion: November 1, 2018
• Study Completion: January 1, 2019
• Last Updated: January 25, 2018

Record last verified: 2017-10

Locations

FR (1)