Emotion and Motivation in Patients With Psychosis

NCT02853019 | Terminated

• 1 other identifier: 6152
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

Anhedonia and avolition reflect emotional and motivational disorders, respectively. However, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. The literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. This project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.

Conditions

Schizophrenia

Keywords

Emotion; motivation; cognition; schizophrenia

Outcome Measures

Primary Outcomes (1)

• Change in the amplitude of the CNV (Contingent Negative Variation) as a function of the primer displayed on the screen

  Before each cognitive trial a primer will be displayed, which will be either neutral or convey emotion or motivation. The investigators will check whether this primer affects the subjects preparation by measuring the CNV, which is an evoked potential recorded with electroencephalography, and indexing preparatory effort.

  During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120)

Secondary Outcomes (1)

• Change in the amplitude of the LPP (Late Positive Potential) as a function of the primer displayed on the screen

  During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120)

Study Arms (2)

Healthy volunteers

SHAM COMPARATOR

Healthy volunteers

Other: Electroencephalogram; Behavioral: Cognitive tasks; Behavioral: subjective evaluation scales

Patients with schizophrenia

EXPERIMENTAL

Patients with schizophrenia

Other: Electroencephalogram; Behavioral: Cognitive tasks; Behavioral: subjective evaluation scales

Interventions

Electroencephalogram OTHER

electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli

Healthy volunteers; Patients with schizophrenia

Cognitive tasks BEHAVIORAL

\- clinical scales and subjective assessments of emotional and motivational stimuli

Healthy volunteers; Patients with schizophrenia

subjective evaluation scales BEHAVIORAL

\- clinical scales and subjective assessments of emotional and motivational stimuli

Healthy volunteers; Patients with schizophrenia

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia

You may not qualify if:

• addiction problem
• invalidating visual sensory problems
• neurological history
• for the healthy volunteers: psychiatric history

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator

Study Sites (1)

Unité INSERM 1114

Strasbourg, 67091, France

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 23, 2016
• First Posted: August 2, 2016
• Study Start: February 2, 2017
• Primary Completion: June 1, 2025
• Study Completion: June 1, 2025
• Last Updated: August 19, 2025

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)