NCT01375894

Brief Summary

The ability to understand the other's perspective and respond accordingly is the most important normal process of daily social life and is probably one of the foundations of human existence. This capability is reflected, inter alia, as an imitation - an important and effective form of learning which is very developed in humans. When we are required to imitate a particular movement, speed of response depends on the perspective of the movement. Imitative response is implemented faster when the movement is observed from first-person perspective, than if the motion is presented from the perspective of a third party. While healthy individuals don't find it difficult to imitate, or to understand the other's emotion expression, there are psychiatric populations (such as autism and schizophrenia) who find it difficult to demonstrate these capabilities (Park, Matthews et al. 2008). Beyond these capabilities impairment, schizophrenic patients have difficulty distinguishing between their arm movements and those of a foreign hand and find it difficult to leave the boundaries of egocentric interpretation of reality and adopt the other's point of view. These behavioral disorders arise from defects in the network of mirror neurons (Buccino and Amore 2008; Langdon, Coltheart et al. 2010). Therefore, the investigator expect that schizophrenic patients will not see a preference for movements that will be displayed in first-person perspective from the same movements that will be displayed from the perspective of a third party. Consequently, the investigator speculate that these subjects will not exhibit differences at imitating the response of which will be presented from different perspectives (Jackson, Meltzoff et (al. 2006.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable schizophrenia

Timeline
Completed

Started Mar 2012

Shorter than P25 for not_applicable schizophrenia

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 14, 2011

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 17, 2011

Completed
9 months until next milestone

Study Start

First participant enrolled

March 1, 2012

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
Last Updated

January 2, 2012

Status Verified

December 1, 2011

Enrollment Period

9 months

First QC Date

June 14, 2011

Last Update Submit

December 29, 2011

Conditions

Outcome Measures

Primary Outcomes (1)

  • speed of hand movement according to the reaction glove

    30 minutes

Study Arms (2)

depresive patients

ACTIVE COMPARATOR

30 patients suffering from depression

Device: imitation assessment using the 5-dt "data glove".

Schizophrenia patients

EXPERIMENTAL

30 Schizophrenia patients

Device: imitation assessment using the 5-dt "data glove".

Interventions

measuring the speed of the hand during imitation

Schizophrenia patientsdepresive patients

Eligibility Criteria

Age20 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Men and women aged 20-65.
  • Subjects who met the criteria for diagnosis of major DSM-IV for schizophrenia or unipolar depression.
  • Subjects with normal or corrected vision.
  • Subjects who sign informed consent for their participation in the experiment

You may not qualify if:

  • Patients with acute disorder, or an unstable patient. Especially neurological disorders or head injuries.
  • Drug Abuse in the past year.
  • Lack of jurisdiction, such as people with mental retardation or dementia.
  • assessed with high suicide risk.
  • patients which are Compulsory hospitalized.
  • Pregnant women

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Shalvata MHC

Hod HaSharon, Israel

Location

MeSH Terms

Conditions

SchizophreniaDepression

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental DisordersBehavioral SymptomsBehavior

Central Study Contacts

Hilik Levkovitz, prof.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 14, 2011

First Posted

June 17, 2011

Study Start

March 1, 2012

Primary Completion

December 1, 2012

Study Completion

December 1, 2012

Last Updated

January 2, 2012

Record last verified: 2011-12

Locations