Simultaneous MEG or fMRI And INtracranial EEG

NCT02342938 | Completed

• 1 other identifier: 2011.698
• Study Type: interventional
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

The SEMAINE project will investigate intracranial EEG (icEEG) simultaneously recorded with either fMRI or MEG to 1) improve identification of the epileptogenic zone in patients suffering from drug-resistant partial epilepsy, and 2) define the functional organization of neural networks underlying human perception and cognition in order to prevent inadvertent deficits resulting from neurosurgical resection. In particular, high-frequency activity (HFA), as measured with icEEG, has been demonstrated in recent years as a relevant index for both epileptogenic tissue and healthy cortical processing, but its correlates in fMRI and MEG require further investigation. This will be a pioneering effort in several respects, as the first to directly measure high-frequency neural activity in tandem with fMRI, and among the first to do so with MEG. In addition to their attractiveness as noninvasive imaging techniques, fMRI and MEG have the potential to examine whole-brain networks that are not accessible to icEEG's necessarily limited spatial coverage. Furthermore, such a campaign of simultaneous recordings will take unprecedented advantage of icEEG as the bridge between the two noninvasive techniques, providing compelling evidence for the links between all three measurements with respect to underlying high-frequency neural activity in both health and disease. This project will therefore lead to improved selection of epilepsy surgery candidates and improved neurosurgical outcomes from the precise mapping of epileptogenic and healthy brain networks. The same techniques will be immediately applicable to functional mapping of other types of neurosurgery populations as well as diagnostic neuroimaging of neurological and psychiatric populations.

Conditions

Epilepsy; Healthy Volunteers

Keywords

Epilepsy surgery; High frequency activity; icEEG; fMRI; MEG

Outcome Measures

Primary Outcomes (2)

• Blood Oxygenation Level Dependent changes, associated with intracranial EEG signal, as determined by simultaneous fMRI and icEEG

  fMRI correlates of epileptic and cognitive-induced high-frequency activities

  Month 2

• MEG signal, associated with intracranial EEG signal, as determined by simultaneous MEG and icEEG

  MEG correlates of epileptic and cognitive-induced high-frequency activities

  Month 2

Study Arms (2)

Patient

EXPERIMENTAL

Procedure: fMRI

Volunteers

EXPERIMENTAL

Procedure: MEG or fMRI And INtracranial EEG

Interventions

MEG or fMRI And INtracranial EEG PROCEDURE

Volunteers

fMRI PROCEDURE

Patient

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged between 18 and 60 years, not subject of any measure of legal protection
• Patients suffering from drug resistant partial epilepsy
• Patient undergoing intracranial video EEG
• Patients with electrodes implanted in orthogonal
• no MRI cons-indication
• Patients who signed a consent form
• Intellectual capacity to perform cognitive tasks and to sign an informed consent.
• Affiliation to social security

You may not qualify if:

• Pregnant women
• Elderly patients under 18 or over 60 years Patient not suffering from drug resistant partial epilepsy, or not scheduled for a SEEG
• MRI cons-indication
• Patients taking psychotropics drugs
• Claustrophobia
• Inability to perform cognitive tasks or to give informed consent.

Sponsors & Collaborators

• Hospices Civils de Lyon: lead
• University of Konstanz: collaborator

Study Sites (1)

Hospices Civils de Lyon

Lyon, 69000, France

Location

Related Publications (1)

• Saignavongs M, Ciumas C, Petton M, Bouet R, Boulogne S, Rheims S, Carmichael DW, Lachaux JP, Ryvlin P. Neural Activity Elicited by a Cognitive Task can be Detected in Single-Trials with Simultaneous Intracerebral EEG-fMRI Recordings. Int J Neural Syst. 2017 Feb;27(1):1750001. doi: 10.1142/S0129065717500010. Epub 2016 Aug 22.

  PMID: 27718767 BACKGROUND

MeSH Terms

Conditions

Epilepsy

Interventions

Magnetoencephalography

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 6, 2014
• First Posted: January 21, 2015
• Study Start: September 16, 2013
• Primary Completion: May 18, 2017
• Study Completion: May 18, 2017
• Last Updated: September 4, 2025

Record last verified: 2025-08

Locations

FR (1)