MRI Study of Saccadic Adaptation

NCT03488082 | Completed

• 2 other identifiers: 69HCL18_02002018-A00932-53
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Accurate execution of our directed behaviors in the immediate environment allows the vast majority of our daily activities. Through the movements of our eyes and different parts of our body, we perceive, explore and act on our environment and can exchange and communicate with others. The mechanisms of sensorimotor adaptation of saccades (saccadic adaptation) contribute on the one hand to maintain the accuracy of saccades in the short, medium and long term, by opposing the deleterious effects of various physiological changes (development, aging), pathological or environmental (optical corrections). The aim of this study is to identify neuronal structures and networks involved in saccadic adaptation through the study of brain metabolic activation (BOLD) during the development of the adaptation of reactive saccades. The study will be organized in a single session with 3 runs. Each run include 4 blocks: 3 include the double-step target paradigm RND, U+, U-) and one without target jump (STA). The 'U+'/ 'U-'blocks include saccadic trials with forward/backward displacement of the target during a targeting saccade, the 'RND' block include saccadic trials with random target jump (forward or backward) and the 'STA' block are trials without displacement of the target. Each subject will make 12 repetitions of the 4 blocks.

Conditions

Healthy Volunteers

Keywords

saccadic adaptation; visual-spatial perception; fMRI

Outcome Measures

Primary Outcomes (1)

• BOLD signal

  cerebral activations with fMRI measures when the subject fixates or shifts gaze toward visual targets (behavioral tasks).

  throughout the behavioral experiment at Day 1

Secondary Outcomes (1)

• Eye movements

  during the development of saccadic adaptation (throughout the behavioral experiments at Day 1)

Study Arms (1)

Measurement of the bold signal

EXPERIMENTAL

Behavioral: fMRI

Interventions

fMRI BEHAVIORAL

saccadic adaptation (target presentations, with or without target jump) during fMRI exam

Measurement of the bold signal

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- Age: 18 to 40 years included,

You may not qualify if:

• Known ophthalmological or neurological pathology,
• Non-stabilized medical condition,
• Taking psychotropic treatment,
• No fluency in reading in French,
• Pregnant and / or breastfeeding woman

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Inserm U1208

Bron, 69500, France

Location

Related Publications (1)

• Metais C, Nicolas J, Diarra M, Cheviet A, Koun E, Pelisson D. Neural substrates of saccadic adaptation: Plastic changes versus error processing and forward versus backward learning. Neuroimage. 2022 Nov 15;262:119556. doi: 10.1016/j.neuroimage.2022.119556. Epub 2022 Aug 12.

  PMID: 35964865 BACKGROUND

Study Officials

• Denis PELISSON

  INSERM U1208

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 28, 2018
• First Posted: April 4, 2018
• Study Start: October 17, 2018
• Primary Completion: July 17, 2020
• Study Completion: July 17, 2020
• Last Updated: September 3, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)