Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

NCT02792010 | Completed

• 1 other identifier: 69HCL14_0235
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.

Conditions

Healthy Volunteers

Keywords

T1rho MRI; hip; cartilage; Healthy participants

Outcome Measures

Primary Outcomes (1)

• Quantification of the cartilage signal at T1rho MRI

  T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram)

  Up to one month after inclusion (Visit 1)

Secondary Outcomes (5)

• Quantification of the cartilage signal at T1rho MRI

  15 (+/- 7) days after visit 1 (Visit 2)

• Quantification of the cartilage signal at T2 MRI

  Up to one month after inclusion (Visit 1)

• Quantification of the cartilage signal at T2 MRI

  15 (+/- 7) days after visit 1 (Visit 2)

• Presence of cartilage lesions

  Up to one month after inclusion (Visit 1)

• Presence of cartilage lesions

  15 (+/- 7) days after visit 1 (Visit 2)

Study Arms (1)

T1rho MRI

EXPERIMENTAL

Patients included had hip cartilage MRI with acquisition of T1rho MRI sequence.

Device: Hip cartilage MRI

Interventions

Hip cartilage MRI DEVICE

Hip cartilage MRI

T1rho MRI

Eligibility Criteria

• Age: 18 Years - 49 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI \<30
• Accepting to participate in the study and signed the written informed consent
• Covered by a health insurance system

You may not qualify if:

• Pregnant woman or risk of pregnancy
• MRI contraindication
• Protected adults
• Language barrier
• Previous or current hip pain

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hospices Civils de Lyon - Hôpital Edouard Herriot Pavillon B Radiologie

Lyon, 69437, France

Location

Related Publications (1)

• Nemeth A, Di Marco L, Boutitie F, Sdika M, Grenier D, Rabilloud M, Beuf O, Pialat JB. Reproducibility of in vivo magnetic resonance imaging T1 rho and T2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers. J Magn Reson Imaging. 2018 Apr;47(4):1022-1033. doi: 10.1002/jmri.25799. Epub 2017 Jun 26.

  PMID: 28650110 RESULT

Study Officials

• Jean-Baptiste PIALAT, MD, PhD

  Hospices Civils de Lyon

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 26, 2016
• First Posted: June 7, 2016
• Study Start: May 1, 2015
• Primary Completion: January 1, 2016
• Study Completion: January 1, 2016
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)