Doses of Coffee and Blood Pressure Response Post-exercise

NCT02335840 | Completed DMC

• 1 other identifier: 21/2011
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

Introduction: reduction of blood pressure after physical exercise is called post exercise hypotension (PEH). However, previous studies demonstrate that ingestion of caffeine equivalent to three tea-cup of coffee abolishes this phenomenon. Objective: evaluate the influence of different doses of coffee in PEH. Methods: eleven hypertensive performed four experimental sessions of aerobic exercise in cycle ergometer (40 minutes of duration, intensity between 60% and 80% of maximum heart rate) succeeds for the ingestion of one (CAF-1), two (CAF-2), three (CAF-3) doses of caffeinated coffee (144 mg/dose), or three doses of decaffeinated coffee (DESC). Blood pressure was measured in rest and during 120 minutes of recovery post exercise, each 10 minutes.

Conditions

Post-Exercise Hypotension; Hypertension

Outcome Measures

Primary Outcomes (1)

• Systolic and diastolic blood pressure. The measures were evaluated for delta (difference between the values obtained in the period of recovery and baseline)

  The sessions CAF-1, CAF-2, CAF-3 and DESC were realized with interval of 72 hours between them, thus, each volunteer devoted an average 20 days to the study.

  The systolic and diastolic blood pressure were measured in CAF-1, CAF-2, CAF-3 and DESC after the baseline and during 120 minutes post-exercise each 10 minutes. Thus, were realized 13 measures of blood pressure in each experimental session.

Study Arms (4)

One dose of coffee

EXPERIMENTAL

Ingestion of one dose of 150 ml of coffee (144 mg of caffeine) ingested 10 minutes post-exercise (denominated CAF-1)

Other: CAF-1

Two doses of coffee

EXPERIMENTAL

Ingestion of two doses of 150 ml of coffee (144 mg of caffeine) ingested 10 and 20 minutes post-exercise (denominated CAF-2)

Other: CAF-2

Three doses of coffee

EXPERIMENTAL

Ingestion of three doses of 150 ml of coffee (144 mg of caffeine) ingested 10, 20 and 30minutes post-exercise (denominated CAF-3)

Other: CAF-3

Three doses of decaffeinated coffee

EXPERIMENTAL

Ingestion of three doses of 150 ml of decaffeinated coffee (144 mg of caffeine) ingested 10, 20 and 30 minutes post-exercise (denominated DESC)

Other: DESC

Interventions

CAF-1 OTHER

In this intervention the volunteers ingested one dose of caffeinated coffee containing 144 mg of caffeine

One dose of coffee

CAF-2 OTHER

In this intervention the volunteers ingested two doses of caffeinated coffee containing 288 mg of caffeine

Two doses of coffee

CAF-3 OTHER

In this intervention the volunteers ingested three doses of caffeinated coffee containing 432mg of caffeine

Three doses of coffee

DESC OTHER

In this intervention the volunteers ingested one dose of decaffeinated coffee containing 108 mg of caffeine

Three doses of decaffeinated coffee

Eligibility Criteria

• Age: 40 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Were included subjects of both gender (three men), 40 to 55 years old, overweight and practitioners of aerobic exercise (walk) at least three months. They were treated with anti-hypertensive medication of class beta-adrenergic receptor blockers, thiazides and enzyme convertor of angiotensin inhibitors, and showing systolic and diastolic values controlled and habituated to coffee consumption.

You may not qualify if:

• Would be excluded from the study volunteers who presented migraine or other withdrawal symptoms due to a washout to be carried out for coffee and other caffeinated foods.

Sponsors & Collaborators

• Federal University of Paraíba: lead

MeSH Terms

Conditions

Post-Exercise Hypotension; Hypertension

Condition Hierarchy (Ancestors)

Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases; Hypotension; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master Student

Study Record Dates

• First Submitted: December 23, 2014
• First Posted: January 12, 2015
• Study Start: March 1, 2011
• Primary Completion: May 1, 2014
• Study Completion: November 1, 2014
• Last Updated: January 12, 2015

Record last verified: 2015-01