NCT02279680

Brief Summary

The objective of this multidisciplinary project is to explore the deficit of associative memory in ASD (Autistic Spectrum Disorder) that could result from abnormal brain connectivity. The hypothesis of abnormal functioning of the fronto-hippocampal network has been evocated but has never been tested. Hence, the present project will include two complementary assessments conducted on a group of adults aged from 18 to 30 with ASD compared to a control group matched in chronological age and intellectual quotient. The first assessment is devoted to the study of associative memory and its EEG correlates and the second focused on the investigation of perceptual strategies related to associative memory using the technique of Eye-tracking. Both behavioral and imaging data would provide new insights on the relationship between perception and memory in ASD.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2014

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2014

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

June 23, 2014

Completed
4 months until next milestone

First Posted

Study publicly available on registry

October 31, 2014

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2015

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2016

Completed
Last Updated

October 31, 2014

Status Verified

October 1, 2014

Enrollment Period

1.5 years

First QC Date

June 23, 2014

Last Update Submit

October 28, 2014

Conditions

Outcome Measures

Primary Outcomes (1)

  • The associative memory index

    2 years

Secondary Outcomes (1)

  • theta and gamma oscillations during the associative memory task

    2 years

Study Arms (2)

Patients

OTHER

Adults between 18 and 30 years old right handing Patients with ASD

Device: ElectroencephalographyBehavioral: Neuropsychological assesments

Healthy volunteers

OTHER

Adults between 18 and 30 years old Right handing Healthy

Device: ElectroencephalographyBehavioral: Neuropsychological assesments

Interventions

Healthy volunteersPatients
Healthy volunteersPatients

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Adult between 18 and 30 years old
  • right handed
  • affiliated to the french national health care system
  • ASD only for the group of patients

You may not qualify if:

  • mental retardation
  • schizophrenia
  • ADHD
  • brain injury with lost of consciousness
  • neurological disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UMR1077 Inserm/EPHE/UCBN

Caen, Caen, 14000, France

RECRUITING

MeSH Terms

Conditions

Autistic Disorder

Interventions

Electroencephalography

Condition Hierarchy (Ancestors)

Autism Spectrum DisorderChild Development Disorders, PervasiveNeurodevelopmental DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, NeurologicalDiagnostic Techniques and ProceduresDiagnosisElectrodiagnosis

Study Officials

  • Jean-Marc BALEYTE, PU-PH

    University Hospital, Caen

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Bérengère GUILLERY-GIRARD, MCU

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 23, 2014

First Posted

October 31, 2014

Study Start

June 1, 2014

Primary Completion

December 1, 2015

Study Completion

December 1, 2016

Last Updated

October 31, 2014

Record last verified: 2014-10

Locations