The Pan African Pulmonary Hypertension Cohort Study
PAPUCO
1 other identifier
observational
254
1 country
1
Brief Summary
The study will recruit and follow up patients for six months patients newly diagnosed with pulmonary hypertension from twelve centers across four countries; South Africa, Mozambique, Cameroon, Nigeria. The main aim of the study is to describe the aetiology, natural history and management practices of pulmonary hypertension in Africa.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2012
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedFirst Submitted
Initial submission to the registry
October 10, 2014
CompletedFirst Posted
Study publicly available on registry
October 16, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedAugust 7, 2015
August 1, 2015
1.5 years
October 10, 2014
August 6, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
mortality
dead or alive status at 6 months post enrolment
6 months
To improve performance and functionality
Six minute walk test
6 months
Interventions
No intervention, this a patient registry and is purely an observational study
Eligibility Criteria
250 patients with pulmonary hypertension (PHT) who reside in sub-Saharan Africa will be enrolled in the registry
You may qualify if:
- Patients of any age who meet clinical and echocardiographic criteria for the diagnosis of PHT will be included
You may not qualify if:
- Patients who are unable, or unlikely, to return for 6 month follow-up will be excluded
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Cape Townlead
- Doula General Hospital, Camerooncollaborator
- Instituto Nacional de Saúde, Mozambiquecollaborator
- Mayo Cliniccollaborator
- Aminu Kano Teaching Hospitalcollaborator
- University of Ibadancollaborator
- Eduardo Mondlane Universitycollaborator
- University of Lagos, Nigeriacollaborator
- Khayelitsha District hospital, Cape Town, South Africacollaborator
- Baker Heart Research Institute, Melbourne, Australiacollaborator
- Pulmonary Vascular Research Institute, UKcollaborator
Study Sites (1)
University of Cape Town
Cape Town, Western Cape, 7925, South Africa
Related Publications (1)
Thienemann F, Dzudie A, Mocumbi AO, Blauwet L, Sani MU, Karaye KM, Ogah OS, Mbanze I, Mbakwem A, Udo P, Tibazarwa K, Damasceno A, Keates AK, Stewart S, Sliwa K. The causes, treatment, and outcome of pulmonary hypertension in Africa: Insights from the Pan African Pulmonary Hypertension Cohort (PAPUCO) Registry. Int J Cardiol. 2016 Oct 15;221:205-11. doi: 10.1016/j.ijcard.2016.06.242. Epub 2016 Jun 29.
PMID: 27404676DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Karen Sliwa-Hahnle, PhD
University of Cape Town
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 6 Months
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 10, 2014
First Posted
October 16, 2014
Study Start
June 1, 2012
Primary Completion
December 1, 2013
Study Completion
June 1, 2015
Last Updated
August 7, 2015
Record last verified: 2015-08