Effects of a PUFA-rich Diet on Acute Metabolic and Inflammatory High-Fat Meal Responses

NCT02246933 | Completed

• 1 other identifier: 503815
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates whether a diet rich in poly-unsaturated fats can compensate for the negative effects of high saturated fat meals on metabolic, inflammatory, and coagulation responses. Half of the participants will receive a high polyunsaturated fat diet )50% carbohydrate, 15% protein, and 35% fat. 21% of total energy will be poly-unsaturated fatty acids, 9% mono-unsaturated fatty acids, and 5% saturated fatty acids) for 7 days, while the other half will receive a control diet 50% carbohydrate, 35% fat, and 15% protein 50% carbohydrate, 35% fat, and 15% protein. Only, 7% of total energy will be poly-unsaturated fatty acids, 15% of total energy will be mono-unsaturated fatty acids, and 13% of total energy will be saturated fatty acids.) for 7 days.

Conditions

Inflammation; Obesity

Outcome Measures

Primary Outcomes (1)

• Change in Blood Markers

  Change in inflammation and coagulation factors

  Change measures baseline and 9 days

Secondary Outcomes (4)

• Change in Energy Expenditure

  Change measures baseline and 9 days

• Change in Substrate Oxidation

  Change measures baseline and 9 days

• Change in Fasting Blood Lipids

  Change measures baseline and 9 days

• Change in Systolic Blood Pressure

  Change measures baseline and 9 days

Study Arms (2)

PUFA Diet

EXPERIMENTAL

Other: PUFA Diet

Control Diet

PLACEBO COMPARATOR

Other: Control Diet

Interventions

PUFA Diet OTHER

The 7-day diet will consist of 50% carbohydrate, 15% protein, and 35% fat. 21% of total energy will be poly-unsaturated fatty acids, 9% mono-unsaturated fatty acids, and 5% saturated fatty acids.

PUFA Diet

Control Diet OTHER

The 7-day diet will consist of 50% carbohydrate, 35% fat, and 15% protein. Furthermore, 7% of total energy will be poly-unsaturated fatty acids, 15% of total energy will be mono-unsaturated fatty acids, and 13% of total energy will be saturated fatty acids.

Control Diet

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Apparently healthy men and women between the ages of 18 and 45y with a normal weight based on body mass index (BMI=18-24.9kg/m2), must be sedentary (perform less than 3 hours per week of structured exercise) and , if participant has fasting total cholesterol \>200 gm/dL, high-density lipoprotein \<40 mg/dL, low-density lipoprotein cholesterol \>100 mg/dL, and/or triglycerides \>150 mg/dL (based on fasting blood lipids).

You may not qualify if:

• Weight loss or gain exceeding 5% of body weight in the past 3 months
• Current participation in a weight loss program
• Any current exercisers (greater than 3h per week)
• Any person who is on a medically prescribed diet
• Any person who is vegan, or any type of vegetarian other than pesco-vegetarian
• Any chronic or metabolic disease, hyperlipidemia, gastrointestinal disorder, or history of medical or surgical events that could affect digestion and absorption of nutrients
• Any current supplement use other than a daily multivitamin (this includes fish oil supplements)
• Any current medication use other than birth control (this includes anti-inflammatory NSAID use).
• Anyone who is pregnant, lactating, or planning a pregnancy
• Anyone who has donated blood or plasma in the last 20 days
• Any tobacco users
• Anyone who has allergies to the most common food allergens (milk, eggs, peanuts, almonds, cashews, walnuts, fish, shellfish, soy and wheat) or to any of the food that will provided during the study
• Anyone who has allergies to any of the components of the liquid meals

Sponsors & Collaborators

• University of Georgia: lead

Study Sites (1)

University of Georgia - Department of Foods and Nutrition

Athens, Georgia, 30602, United States

Location

Related Publications (1)

• Kaviani S, Taylor CM, Stevenson JL, Cooper JA, Paton CM. A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy females but not males: a randomized control trial. BMC Nutr. 2019 Jan 6;5:1. doi: 10.1186/s40795-018-0262-7. eCollection 2019.

  PMID: 32153916 DERIVED

MeSH Terms

Conditions

Inflammation; Obesity

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms

Study Officials

• jamie A Cooper, PhD

  University of Georgia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 18, 2014
• First Posted: September 23, 2014
• Study Start: September 1, 2013
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: October 8, 2015

Record last verified: 2015-10

Locations

US (1)