Effects of the Consumption of Broccoli Sprouts in Overweight Subjects

NCT03390855 | Completed

• 1 other identifier: AGL-2013-46247-P
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Nowadays there is an increasing demand by consumers on healthy food products prepared in convenient forms, simple to use and not containing additives. In this sense, broccoli sprouts (Brassica oleraceae var. italica) represent an interesting choice as they are rich in glucosinolates, nitrogen-sulfur compounds, that are believed to counteract the negative effects of diverse pathologies. Human studies have been focused on the antitumoral properties of these vegetables, however there is less evidence on the anti-inflammatory properties of cruciferous vegetables in humans. As obesity is linked to an inflammatory component, the aim of the study is to evaluate the anti-inflammatory action of broccoli sprouts in overweight adult subjects.

Conditions

Obesity; Inflammation

Keywords

IL-6; Glucosinolate; Brassica oleracea; Sulphoraphane; Biomarkers; Bioavailability; Inflammation

Outcome Measures

Primary Outcomes (2)

• Change in IL-6 levels

  Plasma levels of IL-6 measured at days 0, 70, 90 and 160 days of intervention

  Changes observed from baseline at day 0 compared to 70, 90, 160 days

• Change in C-reactive protein

  Plasma levels of C-reactive protein measured at days 0, 70, 90 and 160 days of intervention

  Changes observed from baseline at day 0 compared to 70, 90, 160 days

Secondary Outcomes (1)

• Bioavailability of glucosinolates from broccoli sprouts

  Changes observed from baseline at day 0 compared to 70, 90, 160 days

Study Arms (1)

Broccoli sprout and follow up

EXPERIMENTAL

Daily consumption of 30 g of raw, fresh, broccoli sprouts, not cooked, during 10 weeks (70 days), followed by other 90 days of no ingestion of broccoli sprouts

Other: Broccoli sprouts

Interventions

Broccoli sprouts OTHER

Broccoli sprout and follow up

Eligibility Criteria

• Age: 35 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI within the overweight range according to the World Health Organization criteria (24.9-29.9 kg/m2), aged 35-55 years, taking no vitamins, supplements or medication during the previous two months; no-smoking.

You may not qualify if:

• Diagnosed diseases as hypertension and cardiovascular pathologies, diabetes, hepatic, gastrointestinal and renal diseases, as well as the intake of drugs related to these pathologies, vegetarian diet, pregnancy or breastfeeding.

Sponsors & Collaborators

• Universidad Católica San Antonio de Murcia: lead
• National Research Council, Spain: collaborator

Related Publications (3)

• Baenas N, Villano D, Garcia-Viguera C, Moreno DA. Optimizing elicitation and seed priming to enrich broccoli and radish sprouts in glucosinolates. Food Chem. 2016 Aug 1;204:314-319. doi: 10.1016/j.foodchem.2016.02.144. Epub 2016 Feb 26.

  PMID: 26988507 BACKGROUND

• Baenas N, Suarez-Martinez C, Garcia-Viguera C, Moreno DA. Bioavailability and new biomarkers of cruciferous sprouts consumption. Food Res Int. 2017 Oct;100(Pt 1):497-503. doi: 10.1016/j.foodres.2017.07.049. Epub 2017 Jul 21.

  PMID: 28873713 BACKGROUND

• Lopez-Chillon MT, Carazo-Diaz C, Prieto-Merino D, Zafrilla P, Moreno DA, Villano D. Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects. Clin Nutr. 2019 Apr;38(2):745-752. doi: 10.1016/j.clnu.2018.03.006. Epub 2018 Mar 13.

  PMID: 29573889 DERIVED

MeSH Terms

Conditions

Obesity; Inflammation

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Study Officials

• Diego Ángel Moreno Fernández, PhD

  National Research Council, Spain

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Proffesor

Model Details: The intervention consisted on a 10-week period which included daily consumption of a portion (30 g) of raw, fresh broccoli sprouts. After the intervention period, a follow-up recovery period for all subjects continued for other 90 days with no ingestion of broccoli sprouts.

Study Record Dates

• First Submitted: December 28, 2017
• First Posted: January 4, 2018
• Study Start: February 1, 2015
• Primary Completion: July 1, 2016
• Study Completion: July 1, 2017
• Last Updated: January 4, 2018

Record last verified: 2017-12

Data Sharing

• IPD Sharing: Will not share