Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects
EBBINGHAUS
A Double-Blind, Placebo Controlled, Multicenter Study to Assess the Effect of Evolocumab on Cognitive Function in Patients With Clinically Evident Cardiovascular Disease and Receiving Statin Background Lipid Lowering Therapy: A Study for Subjects Enrolled in the FOURIER (Study 20110118) Trial
2 other identifiers
interventional
1,974
29 countries
409
Brief Summary
This study evaluated change over time in neurocognitive testing in patients receiving statin therapy in combination with evolocumab (AMG 145), compared with patients receiving statin therapy in combination with placebo.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Sep 2014
409 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 31, 2014
CompletedFirst Posted
Study publicly available on registry
August 4, 2014
CompletedStudy Start
First participant enrolled
September 10, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 11, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
November 11, 2016
CompletedResults Posted
Study results publicly available
January 16, 2018
CompletedJanuary 16, 2018
December 1, 2017
2.2 years
July 31, 2014
December 15, 2017
December 15, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Mean Change From Baseline in Spatial Working Memory Strategy Index of Executive Function (6-8 Boxes) Z Score
Assessments were performed with the Cambridge Neuropsychological Test Automated Battery (CANTAB), a language-independent battery of computerized tests that is used to assess cognitive function. The Spatial Working Memory (SWM) test assesses the cognitive domain of executive function (high-level thinking and decision making). Patients search for colored tokens hidden inside boxes on the screen by touching them. The critical instruction is that once a token has been found inside a box, there will never be a token hidden inside that box again, so patients must not return to a box where a token has been found. The SWM strategy index of executive function represented the number of times a subject began a search with a different box. The Z score represents the standardized measure of how far an individual subject deviates from the study cohort average at baseline. A higher Z score reflects better performance. The mean change from baseline averaged across all the visits is reported.
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).
Secondary Outcomes (3)
Mean Change From Baseline in Spatial Working Memory (SWM) Between-errors Z Score
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).
Mean Change From Baseline in Paired Associated Learning (PAL) Total Errors Adjusted Z Score
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).
Mean Change From Baseline in Reaction Time (RTI) Median 5-choice Reaction Time Z Score
Assessments were conducted at Baseline and at weeks 24, 48, 96, 144 and end of study visit (median time on study was 19.4 months).
Study Arms (2)
Placebo
PLACEBO COMPARATORParticipants received placebo subcutaneous injections either once every 2 weeks (Q2W) or once a month (QM) according to their own preference. Participants continued with their background statin therapy during the course of the study.
Evolocumab
EXPERIMENTALParticipants received evolocumab 140 mg Q2W or 420 mg QM subcutaneous injections according to their own preference. Participants continued with their background statin therapy during the course of the study.
Interventions
Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.
Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.
Participants were required to be on a stable, high- to moderate-intensity statin background therapy consisting of an effective statin dose, ie, at least atorvastatin 20 mg daily or equivalent, and where locally approved, highly effective statin therapy (defined as at least atorvastatin 40 mg daily or equivalent) was recommended.
Eligibility Criteria
You may qualify if:
- Randomized into Study 20110118 (FOURIER; NCT01764633)
You may not qualify if:
- Current or known past diagnosis of dementia or mild cognitive impairment (MCI)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Amgenlead
Study Sites (416)
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Birmingham, Alabama, 35294, United States
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Huntsville, Alabama, 35801, United States
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Mobile, Alabama, 36608, United States
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Glendale, Arizona, 85306, United States
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Phoenix, Arizona, 85018, United States
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Alhambra, California, 91801, United States
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Banning, California, 92220, United States
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Harbor City, California, 90710, United States
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Laguna Hills, California, 92653, United States
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Long Beach, California, 90807, United States
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Long Beach, California, 90822, United States
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Oceanside, California, 92056, United States
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Oxnard, California, 93030, United States
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Palm Springs, California, 92262, United States
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Roseville, California, 95661, United States
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Sacramento, California, 95816, United States
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San Pedro, California, 90732, United States
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Tarzana, California, 91356, United States
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Thousand Oaks, California, 91360, United States
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Aurora, Colorado, 80012, United States
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Colorado Springs, Colorado, 80909, United States
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Denver, Colorado, 80218, United States
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Bridgeport, Connecticut, 06610, United States
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Boynton Beach, Florida, 33472, United States
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Crystal River, Florida, 34429, United States
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Daytona Beach, Florida, 32117, United States
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Deerfield Beach, Florida, 33442, United States
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Fleming Island, Florida, 32003, United States
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Hollywood, Florida, 33021, United States
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Hollywood, Florida, 33024, United States
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Jacksonville, Florida, 32216, United States
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Miami, Florida, 33144, United States
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Palm Harbor, Florida, 34684, United States
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Pembroke Pines, Florida, 33025, United States
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Ponte Vedra, Florida, 32081, United States
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Sarasota, Florida, 34232, United States
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St. Petersburg, Florida, 33713, United States
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Tampa, Florida, 33614, United States
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West Palm Beach, Florida, 33401, United States
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Atlanta, Georgia, 30342, United States
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Augusta, Georgia, 30909, United States
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Gainesville, Georgia, 30501, United States
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Savannah, Georgia, 31406, United States
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Suwanee, Georgia, 30024, United States
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Coeur d'Alene, Idaho, 83814, United States
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Addison, Illinois, 60101, United States
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Belleville, Illinois, 62220, United States
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Chicago, Illinois, 60616, United States
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Jerseyville, Illinois, 62052, United States
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Hammond, Indiana, 46320, United States
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Waterloo, Iowa, 50702, United States
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Hutchinson, Kansas, 67502, United States
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Lexington, Kentucky, 40503, United States
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Owensboro, Kentucky, 42303, United States
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Baton Rouge, Louisiana, 70808, United States
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Hammond, Louisiana, 70403, United States
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Lafayette, Louisiana, 70508, United States
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Metairie, Louisiana, 70006, United States
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Monroe, Louisiana, 71201, United States
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Slidell, Louisiana, 70458, United States
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Biddeford, Maine, 04005, United States
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Salisbury, Maryland, 21804, United States
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Towson, Maryland, 21204, United States
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Haverhill, Massachusetts, 01830, United States
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Newton, Massachusetts, 02459, United States
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Ann Arbor, Michigan, 48106, United States
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Grandville, Michigan, 49418, United States
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Lansing, Michigan, 48912, United States
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Muskegon, Michigan, 49444, United States
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Saint Paul, Minnesota, 55102, United States
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Jefferson City, Missouri, 65109, United States
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St Louis, Missouri, 63117, United States
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St Louis, Missouri, 63128, United States
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Great Falls, Montana, 59405, United States
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Kalispell, Montana, 59901, United States
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Voorhees Township, New Jersey, 08043, United States
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Westwood, New Jersey, 07675, United States
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Brooklyn, New York, 11206, United States
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Buffalo, New York, 14215, United States
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Cortlandt Manor, New York, 10567, United States
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New Hyde Park, New York, 11042, United States
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New Windsor, New York, 12553, United States
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Rochester, New York, 14609, United States
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Troy, New York, 12180, United States
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West Seneca, New York, 14224, United States
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Williamsville, New York, 14221, United States
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Calabash, North Carolina, 28467, United States
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Hickory, North Carolina, 28601, United States
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Hickory, North Carolina, 28602, United States
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Mooresville, North Carolina, 28117, United States
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Raleigh, North Carolina, 27609, United States
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Tabor City, North Carolina, 28463, United States
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Winston-Salem, North Carolina, 27103, United States
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Grand Forks, North Dakota, 58201, United States
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Canton, Ohio, 44708, United States
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Cincinnati, Ohio, 45219, United States
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Columbus, Ohio, 43201, United States
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Columbus, Ohio, 43215, United States
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Dayton, Ohio, 45414, United States
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Springfield, Ohio, 45505, United States
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Toledo, Ohio, 43615, United States
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Pryor, Oklahoma, 74362, United States
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Bend, Oregon, 97701, United States
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Portland, Oregon, 97225, United States
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Portland, Oregon, 97239, United States
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Camp Hill, Pennsylvania, 17011, United States
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Chambersburg, Pennsylvania, 17201, United States
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Feasterville, Pennsylvania, 19053, United States
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Philadelphia, Pennsylvania, 19152, United States
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Pittsburgh, Pennsylvania, 15206, United States
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Pawtucket, Rhode Island, 02860, United States
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Fort Mill, South Carolina, 29707, United States
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Moncks Corner, South Carolina, 29461, United States
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Mt. Pleasant, South Carolina, 29464, United States
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North Myrtle Beach, South Carolina, 29582, United States
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Rapid City, South Dakota, 57701, United States
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Jackson, Tennessee, 38305, United States
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Nashville, Tennessee, 37203, United States
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Tullahoma, Tennessee, 37388, United States
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Austin, Texas, 78758, United States
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Dallas, Texas, 75216, United States
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Houston, Texas, 77025, United States
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Houston, Texas, 77030, United States
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Plano, Texas, 75024, United States
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Wichita Falls, Texas, 76301, United States
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West Jordan, Utah, 84088, United States
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Burke, Virginia, 22015, United States
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Falls Church, Virginia, 22042, United States
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Hopewell, Virginia, 23860, United States
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Richmond, Virginia, 23219, United States
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Richmond, Virginia, 23294, United States
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Suffolk, Virginia, 23435, United States
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Seattle, Washington, 98195, United States
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Green Bay, Wisconsin, 54301, United States
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Woden, Australian Capital Territory, 2605, Australia
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Auchenflower, Queensland, 4066, Australia
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Adelaide, South Australia, 5000, Australia
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Ashford, South Australia, 5035, Australia
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Fullarton, South Australia, 5063, Australia
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Hobart, Tasmania, 7000, Australia
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Box Hill, Victoria, 3128, Australia
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Epping, Victoria, 3076, Australia
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Geelong, Victoria, 3220, Australia
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Aalst, 9300, Belgium
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Bonheiden, 2820, Belgium
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Brussels, 1020, Belgium
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Brussels, 1070, Belgium
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Gozée, 6534, Belgium
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Ieper, 8900, Belgium
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La Louvière, 7100, Belgium
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Liège, 4000, Belgium
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St. John's, Newfoundland and Labrador, A1B 3V6, Canada
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London, Ontario, N6C 0A7, Canada
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Newmarket, Ontario, L3Y 5G8, Canada
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Newmarket, Ontario, L3Y 8C3, Canada
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Peterborough, Ontario, K9J 0B2, Canada
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Sarnia, Ontario, N7T 4X3, Canada
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Chicoutimi, Quebec, G7H 7K9, Canada
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Gatineau, Quebec, J8Y 6S8, Canada
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Pointe-Claire, Quebec, H9R 3J1, Canada
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Québec, Quebec, G1V 4M6, Canada
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Saint-Jean-sur-Richelieu, Quebec, J3A 1C3, Canada
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Saint-Jérôme, Quebec, J7Z 5T3, Canada
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Beroun, 266 01, Czechia
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Bílovec, 743 01, Czechia
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Brandýs nad Labem, 250 01, Czechia
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Brno, 602 00, Czechia
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Brno, 636 00, Czechia
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Brno, 638 00, Czechia
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Chomutov, 430 02, Czechia
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Havlíčkův Brod, 580 22, Czechia
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Hodonín, 695 01, Czechia
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Klatovy IV, 339 01, Czechia
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Liberec, 460 63, Czechia
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Litomyšl, 570 14, Czechia
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Mohelnice, 789 85, Czechia
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Olomouc, 779 00, Czechia
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Ostrava - Vitkovice, 703 00, Czechia
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Pardubice, 530 02, Czechia
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Prague, 101 00, Czechia
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Prague, 128 08, Czechia
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Prague, 130 00, Czechia
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Prague, 140 21, Czechia
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Praha 5 - Smichov, 150 00, Czechia
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Přerov, 750 02, Czechia
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Uherské Hradiště, 686 01, Czechia
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Aalborg, 9000, Denmark
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Ballerup Municipality, 2750, Denmark
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Esbjerg, 6700, Denmark
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Hvidovre, 2650, Denmark
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København S, 2300, Denmark
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Køge, 4600, Denmark
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Vejle, 7100, Denmark
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Paide, 72713, Estonia
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Tallinn, 10128, Estonia
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Tallinn, 10138, Estonia
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Tallinn, 13419, Estonia
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Helsinki, 00180, Finland
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Helsinki, 00290, Finland
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Jyväskylä, 40100, Finland
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Kuopio, 70100, Finland
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Oulu, 90100, Finland
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OYS, 90029, Finland
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Tampere, 33100, Finland
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Turku, 20100, Finland
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Besançon, 25030, France
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Le Coudray, 28630, France
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Montepellier Cedex, 34295, France
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Nantes, 44093, France
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Paris, 75013, France
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Pessac, 33604, France
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Toulouse, 31059, France
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Bad Krozingen, 79189, Germany
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Berlin, 10787, Germany
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Berlin, 12559, Germany
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Berlin, 13353, Germany
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Bochum, 44787, Germany
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Cologne, 50937, Germany
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Dresden, 01307, Germany
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Frankfurt am Main, 60596, Germany
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Hamburg, 20246, Germany
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Hanover, 30159, Germany
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Leipzig, 04103, Germany
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Stuttgart, 70376, Germany
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Witten, 58455, Germany
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Wuppertal, 42117, Germany
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Alexandroupoli, 68100, Greece
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Athens, 11521, Greece
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Athens, 14233, Greece
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Athens, 14561, Greece
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Ioannina, 45500, Greece
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Larissa, 41110, Greece
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Piraeus, 18536, Greece
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Hong Kong, Hong Kong
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Berettyóújfalu, 4100, Hungary
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Békéscsaba, 5600, Hungary
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Budapest, 1036, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7624, Hungary
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Szeged, 6725, Hungary
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Szekszárd, 7100, Hungary
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Szikszó, 3800, Hungary
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Zalaegerszeg, 8900, Hungary
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Pavia, 27100, Italy
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Ichinomiya-shi, Aichi-ken, 491-8551, Japan
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Kasugai-shi, Aichi-ken, 487-0031, Japan
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Nagoya, Aichi-ken, 451-8511, Japan
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Nagoya, Aichi-ken, 457-8511, Japan
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Nagoya, Aichi-ken, 460-0001, Japan
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Toyohashi, Aichi-ken, 440-8510, Japan
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Matsudo-shi, Chiba, 271-0077, Japan
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Saijo-shi, Ehime, 793-0030, Japan
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Chikushi-gun, Fukuoka, 811-1244, Japan
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Fukuoka, Fukuoka, 814-0180, Japan
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Fukuoka, Fukuoka, 814-8522, Japan
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Itoshima-shi, Fukuoka, 819-1104, Japan
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Sapporo, Hokkaido, 060-0031, Japan
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Himeji-shi, Hyōgo, 672-8043, Japan
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Toride-shi, Ibaraki, 302-0022, Japan
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Tsukuba, Ibaraki, 305-8558, Japan
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Kyoto, Kyoto, 615-0035, Japan
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Okinawa-shi, Okinawa, 904-8585, Japan
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Shimajiri-gun, Okinawa, 901-0493, Japan
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Urasoe-shi, Okinawa, 901-2132, Japan
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Osaka, Osaka, 530-0001, Japan
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Osaka, Osaka, 543-0035, Japan
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Saga, Saga-ken, 840-8571, Japan
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Saga, Saga-ken, 849-0917, Japan
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Kawaguchi-shi, Saitama, 332-8558, Japan
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Komatsushima-shi, Tokushima, 773-8502, Japan
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Chuo-ku, Tokyo, 103-0027, Japan
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Daugavpils, 5417, Latvia
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Kuldīga, LV-3301, Latvia
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Liepāja, 3402, Latvia
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Ogre, 5001, Latvia
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Ogre, LV-5003, Latvia
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Riga, 1012, Latvia
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Riga, LV-1001, Latvia
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Vilnius, 10323, Lithuania
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Kuala Lumpur, Kuala Lumpur, 56000, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Arnhem, 6815 AD, Netherlands
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Ede, 6716 RP, Netherlands
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Eindhoven, 5623 EJ, Netherlands
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Hoorn, 1625 HV, Netherlands
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Uden, 5406 PT, Netherlands
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Christchurch, 8011, New Zealand
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Tauranga, 3143, New Zealand
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Ålesund, 6003, Norway
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Hamar, 2317, Norway
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Lierskogen, 3420, Norway
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Oslo, 0450, Norway
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Skedsmokorset, 2020, Norway
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Skien, 3710, Norway
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Stavanger, 4005, Norway
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Gdansk, 80-952, Poland
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Gdynia, 81-384, Poland
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Gdynia, 81-402, Poland
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Katowice, 40-018, Poland
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Katowice, 40-040, Poland
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Katowice, 40-084, Poland
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Kielce, 25-020, Poland
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Krakow, 31-216, Poland
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Krakow, 32-082, Poland
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Lodz, 90-368, Poland
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Lodz, 91-347, Poland
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Lublin, 20-857, Poland
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Olsztyn, 10-010, Poland
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Poznan, 60-702, Poland
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Puławy, 24-100, Poland
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Ruda Śląska, 41-709, Poland
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Staszów, 28-200, Poland
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Świdnik, 21-040, Poland
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Tarnów, 33-100, Poland
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Torun, 87-100, Poland
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Warsaw, 01-192, Poland
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Warsaw, 02-507, Poland
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Warsaw, 04-730, Poland
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Wroclaw, 50-088, Poland
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Wroclaw, 50-349, Poland
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Wroclaw, 51-685, Poland
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Włocławek, 87-800, Poland
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Zamość, 22-400, Poland
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Almada, 2801-951, Portugal
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Carnaxide, 2790-134, Portugal
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Coimbra, 3000-075, Portugal
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Covilha, 6200-251, Portugal
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Ivanovo, 153012, Russia
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Izhevsk, 426063, Russia
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Kemerovo, 650002, Russia
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Kemerovo, 650099, Russia
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Kirov, 610014, Russia
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Moscow, 117292, Russia
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Moscow, 121552, Russia
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Nizhny Novgorod, 603076, Russia
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Novosibirsk, 630089, Russia
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Omsk, 644018, Russia
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Pushkin, 196601, Russia
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Saint Petersburg, 191015, Russia
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Saint Petersburg, 192242, Russia
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Saint Petersburg, 197022, Russia
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Saint Petersburg, 199106, Russia
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Saratov, 410054, Russia
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Tomsk, 634012, Russia
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Yekaterinburg, 620144, Russia
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Bardejov, 085 01, Slovakia
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Brezno, 977 42, Slovakia
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Košice, 040 22, Slovakia
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Lučenec, 984 01, Slovakia
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Moldava nad Bodvou, 045 01, Slovakia
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Nové Zámky, 940 01, Slovakia
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Rimavská Sobota, 979 01, Slovakia
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Rožňava, 048 01, Slovakia
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Snina, 069 01, Slovakia
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Svidník, 08901, Slovakia
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Trenčín, 911 01, Slovakia
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Trnava, 917 01, Slovakia
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Centurion, Gauteng, 0158, South Africa
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Johannesburg, Gauteng, 1724, South Africa
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Johannesburg, Gauteng, 2196, South Africa
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Pretoria, Gauteng, 0184, South Africa
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Pretoria West, Gauteng, 0183, South Africa
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Paarl, Western Cape, 7646, South Africa
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Parow, Western Cape, 7505, South Africa
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Somerset West, Western Cape, 7130, South Africa
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Worcester, Western Cape, 6850, South Africa
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Cape Town, 7530, South Africa
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Kempton Park, 1619, South Africa
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Zaragoza, Aragon, 50009, Spain
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Galdakao, Basque Country, 48960, Spain
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L'Hospitalet de Llobregat, Catalonia, 08907, Spain
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Santiago de Compostela, Galicia, 15706, Spain
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Vigo, Galicia, 36200, Spain
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Valencia, Valencia, 46010, Spain
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Madrid, 28034, Spain
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Helsingborg, 251 87, Sweden
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Linköping, 581 85, Sweden
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Lund, 222 21, Sweden
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Stockholm, 111 35, Sweden
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Stockholm, 171 76, Sweden
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Uddevalla, 451 50, Sweden
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Västerås, 721 89, Sweden
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Adana, 01330, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Gaziantep, 27310, Turkey (Türkiye)
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Istanbul, 34096, Turkey (Türkiye)
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Istanbul, 34865, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Belfast, BT7 2EB, United Kingdom
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Birmingham, B15 2SQ, United Kingdom
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Birmingham, B18 7QH, United Kingdom
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Bournemouth, BH7 7DW, United Kingdom
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Cardiff, CF14 5GJ, United Kingdom
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Chesterfield, S40 4AA, United Kingdom
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Chippenham, SN15 2SB, United Kingdom
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Chorley, PR7 7NA, United Kingdom
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Doncaster, DN9 1EP, United Kingdom
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Glasgow, G20 0SP, United Kingdom
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Glasgow, G45 9AW, United Kingdom
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Hexham, NE46 1QJ, United Kingdom
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Leicester, LE3 9QP, United Kingdom
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Liverpool, L22 0LG, United Kingdom
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Liverpool, L9 7AL, United Kingdom
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London, EC1M 6BQ, United Kingdom
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London, W2 1LA, United Kingdom
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Manchester, M15 6SX, United Kingdom
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Manchester, M23 9LT, United Kingdom
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Newport, PO30 5TG, United Kingdom
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Nuneaton, CV10 7DJ, United Kingdom
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Reading, RG2 0TG, United Kingdom
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Sandbach, CW11 1EQ, United Kingdom
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Sheffield, S5 7AU, United Kingdom
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West Bromwich, B71 4HJ, United Kingdom
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Whitby, YO21 1SD, United Kingdom
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Worcester, WR5 1DD, United Kingdom
Related Publications (3)
Giugliano RP, Mach F, Zavitz K, Kurtz C, Schneider J, Wang H, Keech A, Pedersen TR, Sabatine MS, Sever PS, Honarpour N, Wasserman SM, Ott BR; EBBINGHAUS Investigators. Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial. Clin Cardiol. 2017 Feb;40(2):59-65. doi: 10.1002/clc.22678. Epub 2017 Feb 16.
PMID: 28207168BACKGROUNDGiugliano RP, Mach F, Zavitz K, Kurtz C, Im K, Kanevsky E, Schneider J, Wang H, Keech A, Pedersen TR, Sabatine MS, Sever PS, Robinson JG, Honarpour N, Wasserman SM, Ott BR; EBBINGHAUS Investigators. Cognitive Function in a Randomized Trial of Evolocumab. N Engl J Med. 2017 Aug 17;377(7):633-643. doi: 10.1056/NEJMoa1701131.
PMID: 28813214BACKGROUNDSchmidt AF, Carter JL, Pearce LS, Wilkins JT, Overington JP, Hingorani AD, Casas JP. PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2020 Oct 20;10(10):CD011748. doi: 10.1002/14651858.CD011748.pub3.
PMID: 33078867DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Study Director
- Organization
- Amgen Inc.
Study Officials
- STUDY DIRECTOR
MD
Amgen
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 31, 2014
First Posted
August 4, 2014
Study Start
September 10, 2014
Primary Completion
November 11, 2016
Study Completion
November 11, 2016
Last Updated
January 16, 2018
Results First Posted
January 16, 2018
Record last verified: 2017-12