Postural Changes in Lung Volumes in Obesity

NCT02207192 | Completed

• 1 other identifier: FRC obesity
• Study Type: observational
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Postural changes are known to affect normal lung volumes. A reduction in sitting to supine functional residual capacity (FRC) is well-described in non-obese subjects adopting a supine position. However, postural changes in lung volumes in the obese require further exploration. We aimed to longitudinally address the effects of weight loss on postural changes in lung volumes and pulmonary function, in obesity. We tested the hypothesis that supine reduction in FRC would be absent in morbid obesity and recovered upon weight loss.

Conditions

Obesity

Keywords

obesity, lung volumes, postural changes

Outcome Measures

Primary Outcomes (1)

• functional residual capacity

  baseline and one year after bariatric surgery

Secondary Outcomes (1)

• lung volumes and flows

  at baseline and after bariatric surgery

Study Arms (1)

Morbidly obese

Consecutive morbidly obese adults (BMI over or equal to 40 kg/m2) scheduled for bariatric surgery were prospectively recruited.Subjects with respiratory and cardiac history (asthma, Chronic obstructive pulmonary disease, heart failure) were excluded.

Other: Postural change in lung volumes: sitting to Supine

Interventions

Postural change in lung volumes: sitting to Supine OTHER

Pulmonary function and arterial blood gases were assessed both prior to and after weight loss as part of pre-operative and 12-month follow-up evaluations. Pulmonary function tests were performed both in the sitting and then in the supine position.

Morbidly obese

Eligibility Criteria

• Age: Up to 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Twelve morbidly obese adults (BMI over or equal to 40 kg/m2) scheduled for bariatric surgery at the Montpellier university hospital were recruited. They were 3 men and 9 women.

You may qualify if:

• subjects scheduled for bariatric surgery (BMI over or equal to 40 kg/m2)

You may not qualify if:

• Subjects with respiratory and cardiac history (asthma, COPD, heart failure) were excluded.

Sponsors & Collaborators

• Association pour la Formation du Personnel à la Medecine d'Urgence: lead

Study Sites (1)

Montpellier University hospital

Montpellier, 34295, France

Location

Related Publications (1)

• Sebbane M, El Kamel M, Millot A, Jung B, Lefebvre S, Rubenovitch J, Mercier G, Eledjam JJ, Jaber S, Hayot M. Effect of Weight Loss on Postural Changes in Pulmonary Function in Obese Subjects: A Longitudinal Study. Respir Care. 2015 Jul;60(7):992-9. doi: 10.4187/respcare.03668. Epub 2015 Apr 7.

  PMID: 25852166 DERIVED

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mustapha Sebbane, MD, PhD

  Montpellier University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2014
• First Posted: August 4, 2014
• Study Start: August 1, 2005
• Primary Completion: October 1, 2008
• Study Completion: October 1, 2008
• Last Updated: August 6, 2014

Record last verified: 2014-08

Locations

FR (1)