NCT00379704|CompletedDMC
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Sponsor study identifier
observational
85
1 country
1
Study Start
October 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2010
Actual (reported)Study Completion
October 2010
Actual (reported)Tissue factor is the main activator of coagulation cascades. Excessive tissue factor expression is made responsible of thrombosis in a number of clinical situations including thrombosis in contact with atherosclerotic plaques. Recent work showed that tissue factor gene expression in adipose tissue was significantly increased in obese versus lean mice. The main objective of this study is to show that tissue factor expression is increased in human adipose tissue obtained from obese subjects and to identify its main tissular origin by comparing abdominal and subcutaneous adipose tissue. The secondary objectives are to identify the cell origin of tissue factor (adipocytes versus stromal cells) and to analyze the relation ship between blood tissue factor and (i) tissue factor expressed by adipose tissue, (ii) the amount of subcutaneous and profound adipose tissue, and (iii) coagulation activation markers.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2010
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 21, 2006
Actual (reported)September 22, 2006
Actual (reported)October 2006
Date type not reportedThis date has not been verified as actual or estimated.
October 2010
Actual (reported)October 2010
Actual (reported)Inclusion Criteria: * BMI \> 35 * Stable obesity * Abdominal or pelvic surgery * Agree to participate to the study Exclusion Criteria: * malignancy, * infectious or inflammatory disease, notably HIV infection * pregnancy * history of ischemic cardio or neurovascular event, lower limb arteritis
CHU Louis Mourier
Colombes, 92701, France
Samad F, Pandey M, Loskutoff DJ. Regulation of tissue factor gene expression in obesity. Blood. 2001 Dec 1;98(12):3353-8. doi: 10.1182/blood.v98.12.3353.
samples of plasma and serum and greasy fragments
Alain STEPANIAN, MD PH
Assistance Publique - Hôpitaux de Paris
85 participants (actual enrollment reported by the registry).
First Submitted
September 21, 2006
First Posted
September 22, 2006
Study Start
October 2006
Date type not reportedThis date has not been verified as actual or estimated.
Influence of Cardio-ventilatory Factors on Exercise Intolerance in Obese Adolescents: Effects of Exercise Training
Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects
Contact the study team to confirm eligibility.
Primary Completion
October 2010
Actual (reported)Study Completion
October 2010
Actual (reported)Last Updated
December 8, 2011
Record last verified: 2007-03
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Source: ClinicalTrials.gov.
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