NCT00842569|Completed
Brain Electrophysiological Patterns in Obesity
ERP Study of Brain Electrophysiological Patterns in Obesity
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ERP Study of Brain Electrophysiological Patterns in Obesity
Sponsor study identifier
observational
69
1 country
1
Study Start
January 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2008
Actual (reported)Study Completion
Not reported
Date not reportedThere is growing evidence of behavioural and neurobiological overlaps between obesity and drug abuse. Reduction of the amplitude of P300, a component of event-related potentials (ERP) elicited by an oddball paradigm, is an electrophysiological characteristic and a marker of vulnerability in substance abuse. We want to determine whether obesity is associated with such electrophysiological features during an auditory oddball paradigm. We postulate that obesity could be associated with electrophysiological abnormalities that could be viewed as a possible vulnerability marker for food addiction.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
Date not reportedClick on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2008
Date type not reportedThis date has not been verified as actual or estimated.
December 2008
Actual (reported)February 11, 2009
Actual (reported)February 12, 2009
Actual (reported)Evaluation of amplitudes and latencies of the P300 complex of Event Related Potential during an oddball paradigm, in normal-weighted and obese subjects
BMI\<25
BMI\>30
a healthy but normal-weighted or obese population. Depressive state or eating disorders were carefully evaluated.
Contact the study team to confirm eligibility.
Centre de Recherche en Nutrition Humaine Rhone Alpes
Lyon, F69008, France
Bauer LO, Hesselbrock VM. P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development. Biol Psychiatry. 1999 Jul 15;46(2):263-72. doi: 10.1016/s0006-3223(98)00335-7.
Patrick CJ, Bernat EM, Malone SM, Iacono WG, Krueger RF, McGue M. P300 amplitude as an indicator of externalizing in adolescent males. Psychophysiology. 2006 Jan;43(1):84-92. doi: 10.1111/j.1469-8986.2006.00376.x.
Emmanuel DISSE, MD
CRNH Rhone-Alpes
69 participants (actual enrollment reported by the registry).
First Submitted
February 11, 2009
First Posted
February 12, 2009
Study Start
January 2008
Date type not reportedThis date has not been verified as actual or estimated.
Obesity, Physical Inactivity or Dietary Fat ?
Yoon HH, Iacono WG, Malone SM, McGue M. Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse. Addict Behav. 2006 Jun;31(6):1067-87. doi: 10.1016/j.addbeh.2006.03.036. Epub 2006 Apr 27.
Primary Completion
December 2008
Actual (reported)Last Updated
February 12, 2009
Record last verified: 2009-02
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