Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study

NCT02176174 | Completed DMC

• 3 other identifiers: CALIBER 13-14086091/Z/08/ZRP-PG-0407-10314
• Study Type: observational
• Target: 1,068,318
• Locations: 0 countries
• Sites: N/A

Brief Summary

Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases. This study will examine differences between ethnic groups (White, Black, South Asian and Mixed/Other) and first lifetime presentation of twelve different cardiovascular diseases. This information may help to predict the onset of cardiovascular diseases and inform disease prevention strategies. The hypothesis is that different ethnic groups have differing associations with the range of cardiovascular diseases studied.

Conditions

Abdominal Aortic Aneurysm; Coronary Heart Disease; Sudden Cardiac Death; Intracerebral Haemorrhage; Heart Failure; Ischemic Stroke; Myocardial Infarction; Stroke; Peripheral Arterial Disease; Stable Angina Pectoris; Subarachnoid Haemorrhage; Transient Ischemic Attack; Unstable Angina; Cardiac Arrest

Keywords

Ethnic group; Cardiovascular disease; Atherosclerosis

Outcome Measures

Primary Outcomes (1)

• Initial presentation of cardiovascular disease

  First recorded diagnosis of cardiovascular disease during follow-up: ventricular arrhythmia / sudden cardiac death, heart failure, unheralded coronary death, myocardial infarction, unstable angina, stable angina, abdominal aortic aneurysm, peripheral arterial disease, subarachnoid haemorrhage, intracerebral haemorrhage, ischaemic stroke, transient ischaemic attack

  10 years

Secondary Outcomes (1)

• All cause mortality

  10 years

Study Arms (4)

White

Self-reported ethnic group of Black, using the United Kingdom Census categories, as recorded in electronic health records.

Black

Self-reported ethnic group of Black, using the United Kingdom Census categories, as recorded in electronic health records.

South Asian

Self-reported ethnic group of South Asian, using the United Kingdom Census categories, as recorded in electronic health records.

Mixed/Other

Self-reported ethnic group of Mixed or other, using the United Kingdom Census categories, as recorded in electronic health records.

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients in the CALIBER database who have a record of ethnic group while registered at one of 225 general practices contributing data to CPRD (the Clinical Practice Research Datalink) and consenting to data linkage.

You may qualify if:

• Patients aged 30 and over
• Registered with a participating general practice during the study period
• Minimum one year of records prior to study entry meeting CPRD data quality

You may not qualify if:

• Patients without a record of ethnic group
• Patients without record of gender
• Patients with prior atherosclerotic disease, as recorded in primary care or hospitalisation data
• Pregnant women in the 6 months before the eligibility date

Sponsors & Collaborators

• University College, London: lead
• Wellcome Trust: collaborator
• National Institute for Health Research, United Kingdom: collaborator
• London School of Hygiene and Tropical Medicine: collaborator

Related Publications (2)

• Denaxas SC, George J, Herrett E, Shah AD, Kalra D, Hingorani AD, Kivimaki M, Timmis AD, Smeeth L, Hemingway H. Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER). Int J Epidemiol. 2012 Dec;41(6):1625-38. doi: 10.1093/ije/dys188. Epub 2012 Dec 5.

  PMID: 23220717 BACKGROUND

• George J, Mathur R, Shah AD, Pujades-Rodriguez M, Denaxas S, Smeeth L, Timmis A, Hemingway H. Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients. PLoS One. 2017 Jun 9;12(6):e0178945. doi: 10.1371/journal.pone.0178945. eCollection 2017.

  PMID: 28598987 DERIVED

Related Links

• CALIBER web site and data portal

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal; Coronary Disease; Death, Sudden, Cardiac; Cerebral Hemorrhage; Heart Failure; Ischemic Stroke; Myocardial Infarction; Stroke; Peripheral Arterial Disease; Angina, Stable; Subarachnoid Hemorrhage; Ischemic Attack, Transient; Angina, Unstable; Heart Arrest; Cardiovascular Diseases; Atherosclerosis

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Aortic Diseases; Myocardial Ischemia; Heart Diseases; Death, Sudden; Death; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hemorrhage; Infarction; Ischemia; Necrosis; Arteriosclerosis; Arterial Occlusive Diseases; Peripheral Vascular Diseases; Angina Pectoris; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Brain Ischemia

Study Officials

• Julie George, Phd

  University College, London

  PRINCIPAL INVESTIGATOR

• Harry Hemingway, PhD

  University College, London

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Honorary Research Associate

Study Record Dates

• First Submitted: June 25, 2014
• First Posted: June 26, 2014
• Study Start: December 1, 2013
• Primary Completion: August 1, 2016
• Study Completion: February 1, 2017
• Last Updated: June 8, 2017

Record last verified: 2017-06