Body Mass Index and Initial Presentations of Cardiovascular Diseases

NCT01704300 | Completed DMC

• 1 other identifier: CALIBER 10_14
• Study Type: observational
• Target: 2,240,000
• Locations: 1 country
• Sites: 1

Brief Summary

The association between obesity and cardiovascular disease (CVD) has mostly been studied using broad endpoints or have focused on cause-specific mortality. The investigators aim to compare the effect of body mass index (BMI) on different types of initial presentation of CVD.

Conditions

Abdominal Aortic Aneurysm; Acute Myocardial Infarction; Stroke; Heart Failure; Peripheral Arterial Disease; Angina

Keywords

Abdominal aortic aneurysm; Acute Myocardial Infarction; Coronary heart disease not otherwise specified; Haemorrhagic stroke; Heart failure; Ischaemic stroke; Peripheral arterial disease; Stable angina; Unheralded coronary death; Unstable angina; Ventricular arrhythmias, cardiac arrest and sudden cardiac death; Transient Ischemic Attack

Study Arms (1)

CALIBER Healthy Cohort

We will report findings from the CALIBER (CArdiovascular disease research using Linked BEspoke studies and Electronic Records) collaboration where we linked primary care data (from the General Practice Research Database \[GPRD\]) to three further sources of electronic health records: the Myocardial Ischemia National Audit Project registry (MINAP),cause specific discharge data from Hospital Episodes Statistics (HES) and cause specific mortality from the Office for National Statistics (ONS).

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The cohort we will use in the present analysis has been drawn from patients across 225 practices in England contributing data to GPRD, covering approximately 5% of the UK population (Figure 1). The study period is 1st January 2001 to 25th March 2010 (the date of the last GPRD data submission). To allow time for medical history and risk factors to be measured and recorded we require that patients enter the cohort after having completed at least 1 year of registration with their current practice during which the practice provides data that meet research quality criteria. Patients are followed up from the date they become eligible to be included in the cohort until the earliest date among a) the date of an initial presentation with one of the endpoints of interest, b) the date of leaving the practice or c) the date of last data submission from their practice.

You may qualify if:

• Baseline age ≥30 years

You may not qualify if:

• prior atherosclerotic disease or stroke

Sponsors & Collaborators

• University College, London: lead

Study Sites (1)

University College London

London, WC1E 6BT, United Kingdom

Location

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal; Stroke; Heart Failure; Peripheral Arterial Disease; Angina Pectoris; Hemorrhagic Stroke; Ischemic Stroke; Angina, Stable; Angina, Unstable; Heart Arrest; Death, Sudden, Cardiac; Ischemic Attack, Transient

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Heart Diseases; Atherosclerosis; Arteriosclerosis; Arterial Occlusive Diseases; Peripheral Vascular Diseases; Myocardial Ischemia; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Death, Sudden; Death; Pathologic Processes; Brain Ischemia

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Harry Hemingway, FRCP

Study Record Dates

• First Submitted: October 8, 2012
• First Posted: October 11, 2012
• Study Start: January 1, 2001
• Primary Completion: March 1, 2010
• Study Completion: March 1, 2010
• Last Updated: October 11, 2012

Record last verified: 2012-10

Locations

GB (1)