Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study

NCT01937065 | Unknown DMC

• 1 other identifier: 12_153R_IP4
• Study Type: observational
• Target: 1,937,360
• Locations: 1 country
• Sites: 1

Brief Summary

Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.

Conditions

Abdominal Aortic Aneurysm; Coronary Heart Disease NOS; Unheralded Corronary Death; Intracerebral Haemorrhage; Heart Failure; Ischemic Stroke; Myocardial Infarction; Stroke; Peripheral Arterial Disease; Stable Angina Pectoris; Subarachnoid Haemorrhage; Transient Ischemic Attack; Unstable Angina; Cardiac Arrest, Sudden Cardiac Death

Outcome Measures

Primary Outcomes (1)

• Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases.

  Associations studied: * overall * by sex * by age group * in high risk groups (smokers, hypertensive disease, obese, diabetic, depression) * before and after the introduction of the Quality and Outcomes Framework in England

  Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years

Secondary Outcomes (1)

• Lifetime cumulative incidence per quintile of social deprivation

  Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years

Other Outcomes (1)

• Heterogeneity in associations across 12 cardiovascular diseases using the Tau-squared statistic and I-square statistics.

  Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years

Study Arms (1)

No treatment

Other: No treatment

Interventions

No treatment OTHER

No treatment

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1,93 million patients registered in Clinical Practice Research Datalink (CPRD) practices

You may qualify if:

• One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
• years or older
• Recorded sex

You may not qualify if:

• Pregnant women in the 6 months before the eligibility date

Sponsors & Collaborators

• University College, London: lead
• Wellcome Trust: collaborator
• National Institute for Health Research, United Kingdom: collaborator

Study Sites (1)

University College London

London, WC1E 7HN, United Kingdom

Location

Related Links

• Related Info

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal; Cerebral Hemorrhage; Heart Failure; Ischemic Stroke; Myocardial Infarction; Stroke; Peripheral Arterial Disease; Angina, Stable; Subarachnoid Hemorrhage; Ischemic Attack, Transient; Angina, Unstable; Heart Arrest; Death, Sudden, Cardiac

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases; Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Heart Diseases; Myocardial Ischemia; Infarction; Ischemia; Necrosis; Atherosclerosis; Arteriosclerosis; Arterial Occlusive Diseases; Peripheral Vascular Diseases; Angina Pectoris; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Brain Ischemia; Death, Sudden; Death

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 2, 2013
• First Posted: September 9, 2013
• Study Start: January 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2014
• Last Updated: September 9, 2013

Record last verified: 2013-09

Locations

GB (1)