Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)
Heterogeneity in Association of Heart Rate and Initial Presentation of Cardiovascular Diseases Using Linked Electronic Health Records
2 other identifiers
observational
1,961,286
1 country
1
Brief Summary
Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2012
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2012
CompletedFirst Submitted
Initial submission to the registry
September 12, 2013
CompletedFirst Posted
Study publicly available on registry
September 20, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2014
CompletedSeptember 20, 2013
September 1, 2013
1.9 years
September 12, 2013
September 17, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Risk of atherosclerotic disease in patients with high or low heart rate
Hazard ratios will be also presenting associations between heart rate and initial presentation of different cardiovascular diseases. These associations will be also measured between different levels of heart rate and CVDs stratified by: * by sex * gender * a range of risk factors (such as physical activity, smoking status, drinking status, etc.)
Participants were followed until the first Coronary disease event (an expected average of 5 years)
Secondary Outcomes (1)
Incidence proportions and life time risk for Cardiovascular diseases
Participants were followed until the first Coronary disease event (an expected average of 5 years)
Eligibility Criteria
1,96 million patients registered in Clinical Practice Research Datalink (CPRD) practices
You may qualify if:
- One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
- \> 30 years old
- have at least a recorded heart rate measurement during the study period
You may not qualify if:
- \- Evidence of prior atherosclerotic or cardiac disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University College, Londonlead
- Wellcome Trustcollaborator
- National Institute for Health Research, United Kingdomcollaborator
Study Sites (1)
University College London
London, WC1E 7H, United Kingdom
Related Publications (1)
Archangelidi O, Pujades-Rodriguez M, Timmis A, Jouven X, Denaxas S, Hemingway H. Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study. Eur J Prev Cardiol. 2018 Sep;25(14):1485-1495. doi: 10.1177/2047487318785228. Epub 2018 Jul 2.
PMID: 29966429DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
September 12, 2013
First Posted
September 20, 2013
Study Start
January 1, 2012
Primary Completion
December 1, 2013
Study Completion
December 1, 2014
Last Updated
September 20, 2013
Record last verified: 2013-09