Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition

NCT02143817 | Completed

• 1 other identifier: HSC2012.9674
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals. The use of the amino acid L-citrulline has been suggested as a potential aid for the treatment of CVD by increasing endothelial production of Nitric Oxide (NO). Whole body vibration (WBV) is new and effective form of exercise that is feasible for clinical populations and has been proven to decrease blood pressure (BP) and arterial stiffness and increase muscle mass and strength. Therefore, the purpose of this study was to investigate if the combination of WBV training (WBVT) plus L-citrulline supplementation would induce positive additive effects and would be an effective means to ameliorate arterial stiffness, endothelial function, BP and muscle strength/mass in postmenopausal women.

Conditions

Obesity; Pre-hypertension; Hypertension

Keywords

whole body vibration training; L-citrulline; hypertension; obesity; arterial function; arterial stiffness; autonomic function; endothelial function

Outcome Measures

Primary Outcomes (3)

• Blood Pressure

  Non-invasive measures of brachial and aortic blood pressure

  8 weeks

• Arterial Stiffness and pressure wave reflection

  Using pulse wave velocity of the aorta, systemic, and legs and the augmentation index from radial tonometry

  8 weeks

• Endothelial and autonomic functions

  By measuring circulating levels of adipocytokines (adiponectin and leptin) and endothelial-derived vasodilators (NOx, 6-keto PGFIa, insulin, and ghrelin)and vasoconstrictors (ET-1 and 8-iso PGF2a, VEGF).In addition, heart rate variability, vascular sympathetic activity \[low-frequency power of systolic BP variability\], and spontaneous baroreflex sensitivity will be assessed from electrocardiogram and beat-by-beat digital blood pressure.

  8 weeks

Secondary Outcomes (2)

• Body Composition

  8 weeks

• Muscle Strength

  8 weeks

Study Arms (4)

Control

NO INTERVENTION

This arm involves not making any change to the subject's lifestyle at the moment of the start of the intervention and for 8 wk.

Whole body vibration training plus L-citrulline

EXPERIMENTAL

Lower-body exercise training on a vibration platform combined with L-citrulline supplemetation (6 grams/day)

Dietary Supplement: L-citrulline supplementation; Other: Whole Body Vibration Training

Whole body vibration training & placebo

EXPERIMENTAL

Lower-body exercise training on a vibration platform combined with placebo supplementation (6 grams/day)

Other: Whole Body Vibration Training

L-citrulline supplementation

EXPERIMENTAL

(6g per day)containing L-citrulline

Dietary Supplement: L-citrulline supplementation

Interventions

L-citrulline supplementation DIETARY_SUPPLEMENT

Also known as: 8 weeks of L-citrulline supplementation in two doses of 3g each per day (6g per day)

L-citrulline supplementation; Whole body vibration training plus L-citrulline

Whole Body Vibration Training OTHER

The Whole body vibration training intervention consists of lower-body exercise in a vibration platform 3 times per wk for 8 wk. The subjects will perform static and dynamic exercises for the legs on the vibration platform. Dynamic exercises will be performed with slow controlled movements starting from an upright position into a 60 degree knee flexion (squat) and maximal heel elevation (toestand). Static exercises will be performed without movement in the joint angles described previously. The training volume will increase progressively over the 12-week training period by increasing the intensity of vibration, duration of the exercise set (30-60 sec), number of sets per exercise, and total duration of the training session, and decreasing the duration of rest periods (30-60 sec).The intensity of vibration and amplitude will also be increased progressively (25-30 Hz of frequency and from low to high amplitude).

Whole body vibration training & placebo; Whole body vibration training plus L-citrulline

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female 50 to 70 years of age At least 1 year after menopause Body mass index of 27-39.9 Sedentary or low active (less than 2 hr per wk)

You may not qualify if:

• Younger than 50 or older than 70 years of age Body mass index lower than 27, or 40 or higher Physically active or competitively active Smoker Use of hormone replacement therapy of less than 1 yr Use of calcium channel blocker or beta blockers Use dietary supplementations (e.g.,L-arginine,L-citrulline,antioxidants) Uncontrolled diabetes Any restriction that would significantly interfere with compliance with the L-citrulline supplementation

Sponsors & Collaborators

• Florida State University: lead
• NOW Foods: collaborator

Study Sites (1)

FSU College of Human Sciences

Tallahassee, Florida, 32306, United States

Location

Related Publications (1)

• Wong A, Chernykh O, Figueroa A. Chronic l-citrulline supplementation improves cardiac sympathovagal balance in obese postmenopausal women: A preliminary report. Auton Neurosci. 2016 Jul;198:50-3. doi: 10.1016/j.autneu.2016.06.005. Epub 2016 Jun 24.

  PMID: 27356482 DERIVED

MeSH Terms

Conditions

Obesity; Prehypertension; Hypertension

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Alexei Wong

  Florida State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: May 18, 2014
• First Posted: May 21, 2014
• Study Start: March 1, 2013
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: March 10, 2015

Record last verified: 2015-03

Locations

US (1)