Whole Body Vibration and External Load Exercise Training on Cardiovascular and Autonomic Function in Obese Individuals

NCT02679898 | Completed

• 1 other identifier: HSC201311173
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is directly related to arterial dysfunction and negatively associated to muscle strength. High-intensity resistance exercise is the favored modality to offset muscle weakness, yet, adverse effects on arterial function (pulse wave velocity, wave reflection, and aortic and brachial blood pressures) have been observed. Conventional unloaded-whole body vibration training (WBVT) has improved arterial function in overweight/obese women but appears to be low-intensity. Nevertheless, the effects of moderate-intensity (by adding external load) WBVT on arterial and muscle function are unknown. Therefore, the purpose of this study was to examine whether loaded-WBVT would induce greater benefits than unloaded-WBVT on arterial and muscle function in young overweight/obese women. Furthermore, we examined whether these changes were similar to healthy lean young women.

Conditions

Obesity

Keywords

Arterial function; Whole-body vibration training; Aortic blood pressures; Wave reflection; Muscle strength; Endothelial function; Blood flow

Outcome Measures

Primary Outcomes (2)

• Arterial Stiffness

  Aortic, leg, and systemic pulse wave velocity acquired through non-invasive sensors.

  6 weeks

• Pressure Wave Reflection

  Augmentation index acquired through radial tonometry.

  6 weeks

Secondary Outcomes (5)

• Body Composition

  6 weeks

• Muscle Strength

  6 weeks

• Autonomic Function

  6 weeks

• Blood Pressures

  6 weeks

• Endothelial Function

  6 weeks

Study Arms (4)

Lean Control

NO INTERVENTION

This arm involves not making any changes to the subject's lifestyle at the moment of the start of the intervention and for 6 weeks.

Overweight/Obese Control

NO INTERVENTION

This arm involves not making any changes to the subject's lifestyle at the moment of the start of the intervention and for 6 weeks.

Unloaded-Whole Body Vibration (WBVT)

EXPERIMENTAL

Lower-body exercise training on a vibration platform

Other: Unloaded-Whole Body Vibration (WBVT)

Loaded-Whole Body Vibration (WBVT)

EXPERIMENTAL

Externally loaded lower-body exercise training on a vibration platform

Other: Loaded-Whole Body Vibration (WBVT)

Interventions

Unloaded-Whole Body Vibration (WBVT) OTHER

The unloaded-WBVT intervention consists of four leg exercises performed dynamically over a vibrating platform 3 times/week for 6 weeks. Dynamic movements were performed with controlled movements starting from an upright position into a 90 and 120 degree knee angle, wide-stance squat, and maximal heel elevation. The training volume increased progressively by increasing the intensity of the vibration (30-35 Hz; low-high amplitude), duration of exercise (30-60 sec), number of sets per exercise (2-8), and total during of training session, while decreasing the rest periods (60-30 sec).

Unloaded-Whole Body Vibration (WBVT)

Loaded-Whole Body Vibration (WBVT) OTHER

The loaded-WBVT intervention consists of four leg exercises performed dynamically over a vibrating platform 3 times/week for 6 weeks. Importantly, an external load was applied to a weight vest to account for the necessary weight to perform a specific number of repetitions (progressed from 15-8 repetitions maximum during the 6 weeks). Dynamic movements were performed with controlled movements starting from an upright position into a 90 and 120 degree knee angle, wide-stance squat, and maximal heel elevation. The training volume increased progressively by increasing the intensity of the vibration (30-35 Hz; low-high amplitude), duration of exercise (30-60 sec), number of sets per exercise (2-8), and total during of training session, while decreasing the rest periods (60-30 sec).

Loaded-Whole Body Vibration (WBVT)

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Female
• to 25 years of age
• Sedentary (less than 120 min per wk)
• lean (Body mass index of 18-25 kg/m²)
• overweight/obese (Body mass index of 27-39.9 kg/m²)

You may not qualify if:

• Younger than 18 or older than 25 years of age
• Body mass index lower than 18 or higher than 39.9
• Physically active or competitively active
• Smokers
• Pregnant
• Irregular menstrual cycle
• Use of dietary supplementations (e.g.,L-arginine,L-citrulline,antioxidants)
• Any contraindications to exercise and/or whole-body vibration exercise

Sponsors & Collaborators

• Florida State University: lead

Study Sites (1)

FSU College of Human Sciences

Tallahassee, Florida, 32306, United States

Location

Related Publications (1)

• Alvarez-Alvarado S, Jaime SJ, Ormsbee MJ, Campbell JC, Post J, Pacilio J, Figueroa A. Benefits of whole-body vibration training on arterial function and muscle strength in young overweight/obese women. Hypertens Res. 2017 May;40(5):487-492. doi: 10.1038/hr.2016.178. Epub 2017 Jan 12.

  PMID: 28077859 DERIVED

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Arturo Figueroa

  Florida State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 1, 2016
• First Posted: February 11, 2016
• Study Start: September 1, 2013
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: February 11, 2016

Record last verified: 2016-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)