NCT02141880|Completed
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Sponsor study identifier
observational
25
1 country
1
Study Start
June 2014
Actual (reported)Primary Completion
January 2019
Actual (reported)Study Completion
January 2020
Actual (reported)College drinking associated with sporting events is characterized by excess alcohol, along with food intake, over the duration of hours has the potential to cause a build up of fat in the liver. Fatty liver can increase blood glucose concentrations leading to a prediabetes like state. The present study will determine how overweight men respond to the over-consumption of alcohol/food to identify which characteristics might protect some men from fatty liver, while others might be more susceptible to this condition. The goal of this work is to determine the direct impact of alcohol/food intake to cause acute fatty liver through the stimulation of de novo lipogenesis in 20 overweight, healthy men. Understanding individual susceptibility to alcohol-induced fatty liver will aid in the development of strategies designed to help people mitigate these risks. Hypothesis is that 5h excess consumption of alcohol and food will increase liver triglycerides by 4% or more, in comparison to fasting state.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2020
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 14, 2014
Actual (reported)May 20, 2014
Actual (reported)June 2014
Actual (reported)January 2019
Actual (reported)January 2020
Actual (reported)Liver triglycerides
Liver fat will be measured twice in each subject via magnetic resonance spectroscopy, blood will be drawn hourly and metabolites will be measured enzymatically.
will be measured before (fasting) and after 5 hours of alcohol consumption
All subjects will be under the same protocol which is eating and drinking on one afternoon.
Healthy and overweight sedentary men.
University of Missouri
Columbia, Missouri, 65212, United States
Elizabeth J Parks, PhD
University of Missouri-Columbia
25 participants (actual enrollment reported by the registry).
First Submitted
May 14, 2014
First Posted
May 20, 2014
Study Start
June 2014
Actual (reported)Impact of High Fiber Snacks on Adiposity, Glucose Regulation and Appetite
Contact the study team to confirm eligibility.
Primary Completion
January 2019
Actual (reported)Study Completion
January 2020
Actual (reported)Last Updated
November 2, 2020
Record last verified: 2020-10
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Source: ClinicalTrials.gov.
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