NCT02017067

Brief Summary

Previous studies have demonstrated that resistance training (RT) is beneficial to increase muscle strength, improve functional ability and the ability to rapidly produce force, known as the contractile rate of force development (RFD) in older adults. However, much less research has focused on the effect of RT on the lower extremity muscle strength, contractile RFD and impulse in middle-aged and older people with musculoskeletal conditions, especially for osteoporosis (OP) (or osteopenia) or knee osteoarthritis (KOA). Therefore, the purpose of this study was to investigate the effect of RT on the lower extremity muscle strength, RFD and impulse in middle-aged and older people with musculoskeletal conditions, especially for OP and knee OA (KOA). The investigators hypothesized that such a training program would lead to induce not only specific muscle strength enhancement but also an increment in contractile RFD and impulse.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
58

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2012

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2012

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2013

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2013

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

December 5, 2013

Completed
15 days until next milestone

First Posted

Study publicly available on registry

December 20, 2013

Completed
Last Updated

December 20, 2013

Status Verified

December 1, 2013

Enrollment Period

1.2 years

First QC Date

December 5, 2013

Last Update Submit

December 16, 2013

Conditions

Keywords

Resistance trainingmusculoskeletal conditionsRFD

Outcome Measures

Primary Outcomes (1)

  • Maximum voluntary contraction (MVC)

    Muscle strength was measured as maximum voluntary contraction (MVC) of the quadriceps exerted on an isokinetic dynamometer.

    three months

Secondary Outcomes (2)

  • Contractile rate of force development (RFD)

    three months

  • Impulse

    three months

Study Arms (2)

control

NO INTERVENTION

Maintain regular physical activity as usual, and received health education material about their disease, importance of nutrition and risks factors.

hydraulic resistance circuit training

EXPERIMENTAL

12 weeks resistance training

Procedure: hydraulic resistance circuit training

Interventions

12 weeks (3 times per week, 40 min circuit) of hydraulic resistance circuit training that consisted of 7 types of equipments for different part of strength training.

hydraulic resistance circuit training

Eligibility Criteria

Age45 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • (1) 45 years old or older; (2) diagnosed by a physician with osteoporosis (or osteopenia) or/and osteoarthritis; (3) able to participate safely in a moderately vigorous program of physical activity; (4) not previously taken part in any type of resistance training but were all physically capable of entering exercise.

You may not qualify if:

  • (1) a acute or terminal illness, myocardial infarction within 6 months (or other symptomatic coronary artery disease); (2) uncontrolled hypertension (\> 150/90 mmHg); (3) fracture in the previous 6 months; (3) diseases or medication affecting neuromuscular function; (4) physical limitation in sports and were advised not to exercise by doctors.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tsung-Ching Lin

New Taipei City, Taiwan, 220, Taiwan

Location

MeSH Terms

Conditions

OsteoporosisOsteoarthritis

Condition Hierarchy (Ancestors)

Bone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesArthritisJoint DiseasesRheumatic Diseases

Study Officials

  • Tsung-Ching Lin, Master

    Far Eastern Memorial Hospital

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 5, 2013

First Posted

December 20, 2013

Study Start

April 1, 2012

Primary Completion

July 1, 2013

Study Completion

September 1, 2013

Last Updated

December 20, 2013

Record last verified: 2013-12

Locations