Effective Rehabilitation of Patients Operated With Total Knee Arthroplasty

NCT01877733 | Completed

• 1 other identifier: 2012/1678
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effect of maximal strength training (MST) compared to standard rehabilitation in patients operated with total knee arthroplasty. Previous studies report reduced physical function and muscle strength despite successful surgery inserting an artificial implant. Furthermore, great loss of muscle strength has been found in these patients in the early postoperative phase. The study is a randomized controlled trial. The investigators hypothesize that MST will increase muscle strength and physical function more than standard rehabilitation.

Conditions

Osteoarthritis

Keywords

Resistance training

Outcome Measures

Primary Outcomes (1)

• Muscle strength in leg extension and leg press

  Measured preoperatively implies measuring the outcome within the last month prior to surgery

  Measured preoperatively, after 7 days, 10 wks and 1 year

Secondary Outcomes (4)

• 6 minute walk test

  preopertively, 7 days postoperatively and after 1 year

• KOOS; Knee injury and osteosarthritis outcome score

  Preoperatively (within 1 month prior to surgery), 7 days postoperatively and 10 wks and 1 year postoperatively

• EQ-5D (measure of health outcome)

  Preoperatively (within 1 month prior to surgery), 7 days, 10 wks and 1 year postoperatively

• VAS scale recording pain

  preoperatively (within 1 month prior to surgery), 7 days, 10 wks and 1 year postoperatively

Study Arms (2)

Maximal strenght training

EXPERIMENTAL

Training maximal strength training 3 times a week/1 physiotherapy session for 8 weeks

Other: Maximal strength training

Standard rehabilitation

NO INTERVENTION

2-3 physiotherapy sessions a week for 8 weeks/telephone contact by project leader once a week/writing training diary

Interventions

Maximal strength training OTHER

Maximal strenght training

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• unilateral osteoarthritis,
• \< 75 years

You may not qualify if:

• disease(s) that compromise testing/training,
• unable to understand written and verbal instructions and information,
• osteoarthritis in the contralateral leg that needs treatment.

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead
• St. Olavs Hospital: collaborator
• Helse Nord-Trøndelag HF: collaborator

Study Sites (1)

St. Olavs hospital

Trondheim, 7006, Norway

Location

Related Publications (2)

• Husby VS, Foss OA, Husby OS, Winther SB. Randomized controlled trial of maximal strength training vs. standard rehabilitation following total knee arthroplasty. Eur J Phys Rehabil Med. 2018 Jun;54(3):371-379. doi: 10.23736/S1973-9087.17.04712-8. Epub 2017 Sep 13.

  PMID: 28901118 RESULT

• Winther SB, Foss OA, Klaksvik J, Husby VS. Pain and load progression following an early maximal strength training program in total hip- and knee arthroplasty patients. J Orthop Surg (Hong Kong). 2020 Jan-Apr;28(2):2309499020916392. doi: 10.1177/2309499020916392.

  PMID: 32301372 RESULT

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Vigdis S Husby, PhD

  Norwegian University of Science and Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2013
• First Posted: June 14, 2013
• Study Start: January 1, 2013
• Primary Completion: July 1, 2015
• Study Completion: July 1, 2015
• Last Updated: April 22, 2020

Record last verified: 2020-04

Locations

NO (1)