NCT01482130

Brief Summary

The current guidelines emphasize the prevention of bone loss, by building up bone mass in young age, as one of the most important measures to reduce the incidence of osteoporosis. Strength training and "explosive" exercises have been shown to have beneficial effects on bone mass and bone metabolism in both young and postmenopausal women. However, meta-analysis concludes that it is still unclear what type of exercises, intensity and execution that is most effective for skeletal adaptations. The following study will examine the effect of 12 weeks of heavy, explosive strength training on bone mineral density and bone metabolism in young, healthy girls aged 18-30 years.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2011

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2011

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

November 16, 2011

Completed
14 days until next milestone

First Posted

Study publicly available on registry

November 30, 2011

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2012

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2012

Completed
Last Updated

August 1, 2016

Status Verified

July 1, 2016

Enrollment Period

5 months

First QC Date

November 16, 2011

Last Update Submit

July 29, 2016

Conditions

Keywords

Exerciseosteoporosisprevention

Outcome Measures

Primary Outcomes (1)

  • Bone mineral density

    (Dual X-ray Absorptiometry)

    Baseline and 12 weeks

Secondary Outcomes (4)

  • Serum markers of bone metabolism

    Baseline and 12 weeks

  • Body composition

    Baseline and 12 weeks

  • Maximal muscle strength

    Baseline and 12 weeks

  • Rate of force development

    Baseline and 12 weeks

Study Arms (2)

Training group

EXPERIMENTAL

All participants in the training group will pursue a 12 weeks of strength training.

Behavioral: Heavy, explosive strength training

Controls

OTHER

The control group will be encouraged to follow a training program according to recommended exercise guidelines

Behavioral: recommendations

Interventions

All participants of the training group will pursue a 12 weeks of heavy, explosive strength training, 3 sessions a week for a total of 36 sessions. The training session will include one squat exercise only, which allows muscle contraction of the quadriceps from a 90° bend at the knees to straight legs.

Training group
recommendationsBEHAVIORAL

The control group will be encouraged to follow a training program according to recommended exercise guidelines: * Weight bearing activities (walking, jogging or strength training) * 30 - 60 minutes, 3 - 5 times each week * A total of 2 - 3 hours each week should be achieved

Controls

Eligibility Criteria

Age18 Years - 30 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Participants include young and healthy women between the ages of 18-30, who have not engaged in strength training for the last 6 months.

You may not qualify if:

  • Subjects will be excluded from the study if they have any condition that preclude them from taking part in the exercise testing procedures or the 24 week exercise program or if they fail to obtain the required amount of training sessions.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Norwegian University of Science and Technology

Trondheim, Sor.tronderlag, 7030, Norway

Location

Related Publications (1)

  • Mosti MP, Carlsen T, Aas E, Hoff J, Stunes AK, Syversen U. Maximal strength training improves bone mineral density and neuromuscular performance in young adult women. J Strength Cond Res. 2014 Oct;28(10):2935-45. doi: 10.1519/JSC.0000000000000493.

MeSH Terms

Conditions

OsteoporosisMotor Activity

Interventions

Health Planning Guidelines

Condition Hierarchy (Ancestors)

Bone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesBehavior

Intervention Hierarchy (Ancestors)

Health PlanningHealth Care Economics and Organizations

Study Officials

  • Unni Syversen, MD, PhD

    Norwegian University of Science and Technology

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 16, 2011

First Posted

November 30, 2011

Study Start

November 1, 2011

Primary Completion

April 1, 2012

Study Completion

June 1, 2012

Last Updated

August 1, 2016

Record last verified: 2016-07

Locations