Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

NCT02003222 | Active Not Recruiting Phase 3 Results FDA Drug

• 7 other identifiers: NCI-2013-02229ECOG-E1910PE1910_A08PAMDREVW01E1910U10CA021115U10CA180820U24CA196172
• Study Type: interventional
• Target: 488
• Locations: 4 countries
• Sites: 545

Brief Summary

This randomized phase III trial studies combination chemotherapy with blinatumomab to see how well it works compared to induction chemotherapy alone in treating patients with newly diagnosed breakpoint cluster region (BCR)-c-abl oncogene 1, non-receptor tyrosine kinase (ABL)-negative B lineage acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as blinatumomab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether combination chemotherapy is more effective with or without blinatumomab in treating newly diagnosed acute lymphoblastic leukemia.

Conditions

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative; Acute Lymphoblastic Leukemia

Outcome Measures

Primary Outcomes (1)

• Overall Survival (OS) Among Patients Who Were MRD Negative After Induction and Intensification Chemotherapy

  Overall survival is defined as the time from randomization to death of any cause.

  Assessed every 3 months for 2 years, then every 6 months for 3 years, then annually for 5 years

Secondary Outcomes (4)

• Relapse-free Survival (RFS) Among Patients Who Were MRD Negative After Induction and Intensification Chemotherapy

  Assessed every 3 months for 2 years, then every 6 months for 3 years, then annually for 5 years

• RFS Among of Those Who Are MRD+ at Randomization and Then Convert to MRD- After 2 Cycles of Blinatumomab to Those Patients Who Are MRD- at Randomization and Remain MRD- After 2 Cycles of Blinatumomab or Consolidation Chemotherapy

  Assessed every 3 months for 2 years, then every 6 months for 3 years, then annually for 5 years

• OS Among of Those Who Are MRD+ at Randomization and Then Convert to MRD- After 2 Cycles of Blinatumomab to Those Patients Who Are MRD- at Randomization and Remain MRD- After 2 Cycles of Blinatumomab or Consolidation Chemotherapy

  Assessed every 3 months for 2 years, then every 6 months for 3 years, then annually for 5 years

• OS Among MRD Negative Patients Who Proceed to Allogeneic Transplant on Study

  Assessed every 3 months for 2 years, then every 6 months for 3 years, then annually for 5 years

Other Outcomes (2)

• To Determine Differences in MRD Kinetics Among Patients With the BCR/ABL1-like B-lineage ALL, and to Compare the OS (and RFS) of Patients With BCR-ABL-like Phenotype With Those Without BCR-ABLlike Phenotype

  Assessed every 3 months for 2 years, then every 6 months for 3 years, then annually for 5 years

• Incidence of Anti-blinatumomab Antibody Formation

  Assessed at baseline, end of 2 cycles of blinatumomab, end of 4 cycles of blinatumomab, and end of blinatumomab treatment

Study Arms (2)

Arm I (blinatumomab, chemotherapy)

EXPERIMENTAL

See Detailed Description

Procedure: Allogeneic Hematopoietic Stem Cell Transplantation; Procedure: Biospecimen Collection; Biological: Blinatumomab; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Etoposide; Drug: Leucovorin Calcium; Procedure: Lumbar Puncture; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Biological: Rituximab; Drug: Vincristine; Drug: Vincristine Sulfate; Procedure: X-Ray Imaging

Arm II (chemotherapy)

ACTIVE COMPARATOR

See Detailed Description

Procedure: Allogeneic Hematopoietic Stem Cell Transplantation; Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Etoposide; Drug: Leucovorin Calcium; Procedure: Lumbar Puncture; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Biological: Rituximab; Drug: Vincristine; Drug: Vincristine Sulfate; Procedure: X-Ray Imaging

Interventions

Allogeneic Hematopoietic Stem Cell Transplantation PROCEDURE

Undergo allogeneic hematopoietic SCT

Also known as: Allogeneic, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Stem Cell Transplantation, Allogeneic

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Biospecimen Collection PROCEDURE

Undergo blood sample collection

Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Blinatumomab BIOLOGICAL

Given IV

Also known as: AMG 103, AMG-103, AMG103, Anti-CD19 x Anti-CD3 Bispecific Monoclonal Antibody, Anti-CD19/Anti-CD3 Recombinant Bispecific Monoclonal Antibody MT103, Blincyto, MEDI 538, MEDI-538, MEDI538, MT 103, MT-103, MT103

Arm I (blinatumomab, chemotherapy)

Bone Marrow Aspiration PROCEDURE

Undergo bone marrow aspiration

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Bone Marrow Biopsy PROCEDURE

Undergo bone marrow biopsy

Also known as: Biopsy of Bone Marrow, Biopsy, Bone Marrow

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Cyclophosphamide DRUG

Given IV

Also known as: (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Cytarabine DRUG

Given IT, IV, or SC

Also known as: .beta.-Cytosine arabinoside, 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-.beta.-D-Arabinofuranosylcytosine, 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-Beta-D-arabinofuranosylcytosine, 1.beta.-D-Arabinofuranosylcytosine, 2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-, 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-, Alexan, Ara-C, ARA-cell, Arabine, Arabinofuranosylcytosine, Arabinosylcytosine, Aracytidine, Aracytin, Aracytine, Beta-Cytosine Arabinoside, CHX-3311, Cytarabinum, Cytarbel, Cytosar, Cytosine Arabinoside, Cytosine-.beta.-arabinoside, Cytosine-beta-arabinoside, Erpalfa, Starasid, Tarabine PFS, U 19920, U-19920, Udicil, WR-28453

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Daunorubicin DRUG

Given IV

Also known as: Daunomycin, Daunorrubicina, DNR, Leukaemomycin C, Rubidomycin, Rubomycin C

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Daunorubicin Hydrochloride DRUG

Given IV

Also known as: Cerubidin, Cerubidine, Cloridrato de Daunorubicina, Daunoblastin, Daunoblastina, Daunoblastine, Daunomycin Hydrochloride, Daunomycin, hydrochloride, Daunorubicin.HCl, Daunorubicini Hydrochloridum, FI-6339, Ondena, RP-13057, Rubidomycin Hydrochloride, Rubilem

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Dexamethasone DRUG

Given PO

Also known as: Aacidexam, Adexone, Aknichthol Dexa, Alba-Dex, Alin, Alin Depot, Alin Oftalmico, Amplidermis, Anemul mono, Auricularum, Auxiloson, Baycadron, Baycuten, Baycuten N, Cortidexason, Cortisumman, Decacort, Decadrol, Decadron, Decadron DP, Decalix, Decameth, Decasone R.p., Dectancyl, Dekacort, Deltafluorene, Deronil, Desamethasone, Desameton, Dexa-Mamallet, Dexa-Rhinosan, Dexa-Scheroson, Dexa-sine, Dexacortal, Dexacortin, Dexafarma, Dexafluorene, Dexalocal, Dexamecortin, Dexameth, Dexamethasone Intensol, Dexamethasonum, Dexamonozon, Dexapos, Dexinoral, Dexone, Dinormon, Dxevo, Fluorodelta, Fortecortin, Gammacorten, Hemady, Hexadecadrol, Hexadrol, LenaDex, Lokalison-F, Loverine, Methylfluorprednisolone, Millicorten, Mymethasone, Orgadrone, Spersadex, TaperDex, Visumetazone, ZoDex

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Etoposide DRUG

Given IV

Also known as: Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Leucovorin Calcium DRUG

Given IV or PO

Also known as: Adinepar, Calcifolin, Calcium (6S)-Folinate, Calcium Folinate, Calcium Leucovorin, Calfolex, Calinat, Cehafolin, Citofolin, Citrec, Citrovorum Factor, Cromatonbic Folinico, Dalisol, Disintox, Divical, Ecofol, Emovis, Factor, Citrovorum, Flynoken A, Folaren, Folaxin, FOLI-cell, Foliben, Folidan, Folidar, Folinac, Folinate Calcium, folinic acid, Folinic Acid Calcium Salt Pentahydrate, Folinoral, Folinvit, Foliplus, Folix, Imo, Lederfolat, Lederfolin, Leucosar, leucovorin, Rescufolin, Rescuvolin, Tonofolin, Wellcovorin

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Lumbar Puncture PROCEDURE

Undergo lumbar puncture

Also known as: LP, Spinal Tap

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Mercaptopurine DRUG

Given PO

Also known as: 3H-Purine-6-thiol, 6 MP, 6 Thiohypoxanthine, 6 Thiopurine, 6-Mercaptopurine, 6-Mercaptopurine Monohydrate, 6-MP, 6-Purinethiol, 6-Thiopurine, 6-Thioxopurine, 6H-Purine-6-thione, 1,7-dihydro- (9CI), 7-Mercapto-1,3,4,6-tetrazaindene, Alti-Mercaptopurine, Azathiopurine, Bw 57-323H, Flocofil, Ismipur, Leukerin, Leupurin, Mercaleukim, Mercaleukin, Mercaptina, Mercaptopurinum, Mercapurin, Mern, NCI-C04886, Puri-Nethol, Purimethol, Purine, 6-mercapto-, Purine-6-thiol (8CI), Purine-6-thiol, monohydrate, Purinethiol, Purinethol, U-4748, WR-2785

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Methotrexate DRUG

Given PO, IT or IV

Also known as: Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Jylamvo, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Pegaspargase DRUG

Given IM or IV

Also known as: L-Asparaginase with Polyethylene Glycol, Oncaspar, Oncaspar-IV, PEG-Asparaginase, PEG-L-Asparaginase, PEG-L-Asparaginase (Enzon - Kyowa Hakko), PEGLA, Polyethylene Glycol L-Asparaginase, Polyethylene Glycol-L-Asparaginase

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Prednisone DRUG

Given PO

Also known as: .delta.1-Cortisone, 1, 2-Dehydrocortisone, Adasone, Cortancyl, Dacortin, DeCortin, Decortisyl, Decorton, Delta 1-Cortisone, Delta-Dome, Deltacortene, Deltacortisone, Deltadehydrocortisone, Deltasone, Deltison, Deltra, Econosone, Lisacort, Meprosona-F, Metacortandracin, Meticorten, Ofisolona, Orasone, Panafcort, Panasol-S, Paracort, Perrigo Prednisone, PRED, Predicor, Predicorten, Prednicen-M, Prednicort, Prednidib, Prednilonga, Predniment, Prednisone Intensol, Prednisonum, Prednitone, Promifen, Rayos, Servisone, SK-Prednisone

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Rituximab BIOLOGICAL

Given IV

Also known as: ABP 798, ABP-798, ABP798, BI 695500, BI-695500, BI695500, Blitzima, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT P10, CT-P10, CTP10, GP 2013, GP-2013, GP2013, IDEC 102, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, IDEC102, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF 05280586, PF-05280586, PF05280586, Riabni, Ritemvia, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar GP2013, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-blit, Rituximab-pvvr, Rituximab-rite, Rituximab-rixa, Rituximab-rixi, Rixathon, Riximyo, RTXM 83, RTXM-83, RTXM83, Ruxience, Truxima

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Vincristine DRUG

Given IV

Also known as: LCR, Leurocristine, VCR, Vincrystine

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Vincristine Sulfate DRUG

Given IV

Also known as: Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

X-Ray Imaging PROCEDURE

Undergo x-ray imaging

Also known as: Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray

Arm I (blinatumomab, chemotherapy); Arm II (chemotherapy)

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• PRE-REGISTRATION
• Diagnostic bone marrow and/or peripheral blood specimens must be submitted for immunophenotyping and selected molecular testing, and the establishment of BCR/ABL status; testing will be performed by the Eastern Cooperative Oncology Group (ECOG)-American College of Radiation Imaging Network (ACRIN) Leukemia Translational Research Laboratory (LTRL) and reported to the institution
• NOTE: IT IS ESSENTIAL THAT A SAMPLE CONTAINING SUFFICIENT BLAST CELLS BE SUBMITTED TO THE ECOG-ACRIN LTRL AT BASELINE SO THAT SUBSEQUENT BONE MARROW ASSESSMENTS OF MRD CAN BE DONE; IN ADDITION TO ALLOWING THE LTRL TO CONFIRM ELIGIBILITY BASED ON BLAST CELL IMMUNOPHENOTYPE AND BCR/ABL STATUS, IT IS ALSO IMPERATIVE THAT AN ADEQUATE NUMBER OF BLASTS BE BANKED FOR ANALYSIS BY DRS MULLIGHAN/WILLMAN. WITHOUT ADEQUATE BASELINE SAMPLES, PATIENTS WILL NOT BE ABLE TO BE TREATED AND RANDOMIZED ON THIS PROTOCOL; IF A BONE MARROW ASPIRATE IS NOT AVAILABLE FOR LTRL SUBMISSION AT BASELINE, IT IS IMPERATIVE THAT DR PAIETTA FROM THE LTRL IS CALLED TO DISCUSS THE PERIPHERAL BLOOD WHITE BLOOD CELL (WBC) AND BLAST COUNT BEFORE BLOOD ONLY IS SUBMITTED
• NOTE: Hydroxyurea can be given for up to 5 days prior to initiation of protocol therapy for control of leukocyte count and/or other symptoms or signs; corticosteroids can be given after pre-registration to the protocol and submission of baseline marrow and blood samples for control of leukocyte count and/or other symptoms or signs prior to initiation of protocol therapy if needed; if corticosteroids are given prior to pre-registration, contact the study chair as the patient may still be eligible to participate
• INDUCTION ELIGIBILITY CRITERIA-STEP 1
• Age \>= 30 years and =\< 70 years
• New diagnosis of B lineage ALL must be made upon bone marrow or peripheral blood immunophenotyping; cases with myeloid antigen expression, but unequivocal lymphoid immunophenotype, are eligible
• Negativity for the Philadelphia chromosome must be established by conventional cytogenetics, fluorescence in situ hybridization (FISH) and/or polymerase chain reaction (PCR); patients who are negative for the Philadelphia chromosome by conventional cytogenetics must have FISH or PCR performed for BCR/ABL to exclude occult translocations
• Cytogenetic analysis must be performed from diagnostic bone marrow (preferred) or if adequate number of circulating blasts from peripheral blood; FISH testing for common B-lineage ALL abnormalities including t(9;22) (BCR/ABL1), t(12;21) (ETS-variant gene 6 \[ETV6\]/runt-related transcription factor 1 \[RUNX1\]), t(1;19) (pre-B-cell leukemia homeobox 1 \[PBX1\]/transcription factor 3 \[TCF3\]), +4,+10,+17, (centromeric \[Cen\]4/Cen10/Cen17), t(11q23;var), (myeloid/lymphoid or mixed lineage leukemia \[MLL\]), deletion (del)(9p) (cyclin-dependent kinase inhibitor 2A \[CDKN2A\]/Cen9), and t(14;var) (immunoglobulin heavy chain \[IGH\] is encouraged); if there are few or no circulating blasts and an adequate marrow sample cannot be obtained for cytogenetic analysis, the patient may still enroll on the trial
• Serum direct bilirubin \< 2 mg/dl or serum total bilirubin =\< 3 (obtained =\< 48 hours prior to registration); NOTE: the above stipulation for normal hepatic function does not apply if liver dysfunction is due to leukemia infiltration
• Serum creatinine \< 2 mg/dl (obtained =\< 48 hours prior to registration); NOTE: the above stipulation for normal hepatic function does not apply if liver dysfunction is due to leukemia infiltration
• Patient should be human leukocyte antigen (HLA) typed (A, B, C, DR and DQ) during induction therapy phase or a written explanation for not undergoing HLA typing on the flow sheet
• Patients with known human immunodeficiency virus (HIV) infection are eligible if they meet all of the following criteria:
• Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the leukemia
• Patient must have serum HIV viral load of \< 200 copies/mm\^3

You may not qualify if:

• Mature B ALL (Burkitt's-like leukemia) is excluded from enrollment in this trial; pre-study bone marrow biopsy and aspirate must be completed =\< 1 week prior to registration
• Patient must not have a concurrent active malignancy for which they are receiving treatment
• Patient must not have intercurrent organ damage or medical problems that will jeopardize the outcome of therapy (i.e., psychiatric disorder, drug abuse, pregnancy)
• Patient must not have an antecedent hematologic disorder
• Patient must not have a history or presence of clinically relevant central nervous system (CNS) pathology such as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia; Parkinson's disease, cerebellar disease, organic brain syndrome, psychosis, or other significant CNS abnormalities
• Patient must not have an active uncontrolled infection

Sponsors & Collaborators

• National Cancer Institute (NCI): lead
• Canadian Cancer Trials Group: collaborator

Study Sites (545)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States

Location

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States

Location

Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States

Location

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States

Location

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States

Location

Alaska Regional Hospital

Anchorage, Alaska, 99508, United States

Location

Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States

Location

Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States

Location

Katmai Oncology Group

Anchorage, Alaska, 99508, United States

Location

Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States

Location

Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701, United States

Location

Kingman Regional Medical Center

Kingman, Arizona, 86401, United States

Location

Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States

Location

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States

Location

Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States

Location

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

Location

PCR Oncology

Arroyo Grande, California, 93420, United States

Location

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States

Location

Community Cancer Institute

Clovis, California, 93611, United States

Location

University Oncology Associates

Clovis, California, 93611, United States

Location

UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States

Location

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States

Location

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States

Location

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States

Location

The Medical Center of Aurora

Aurora, Colorado, 80012, United States

Location

Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States

Location

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States

Location

Cancer Center of Colorado at Sloan's Lake

Denver, Colorado, 80204, United States

Location

National Jewish Health-Main Campus

Denver, Colorado, 80206, United States

Location

The Women's Imaging Center

Denver, Colorado, 80209, United States

Location

Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States

Location

Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States

Location

Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States

Location

Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States

Location

Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States

Location

Rose Medical Center

Denver, Colorado, 80220, United States

Location

Western Surgical Care

Denver, Colorado, 80220, United States

Location

Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113, United States

Location

Swedish Medical Center

Englewood, Colorado, 80113, United States

Location

National Jewish Health-Western Hematology Oncology

Golden, Colorado, 80401, United States

Location

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States

Location

Grand Valley Oncology

Grand Junction, Colorado, 81505, United States

Location

Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States

Location

Good Samaritan Hospital - Cancer Centers of Colorado

Lafayette, Colorado, 80026, United States

Location

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States

Location

Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States

Location

Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States

Location

Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States

Location

National Jewish Health-Northern Hematology Oncology

Thornton, Colorado, 80260, United States

Location

Intermountain Health Lutheran Hospital

Wheat Ridge, Colorado, 80401, United States

Location

Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States

Location

Yale University

New Haven, Connecticut, 06520, United States

Location

Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790, United States

Location

Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States

Location

UM Sylvester Comprehensive Cancer Center at Coral Springs

Coral Springs, Florida, 33065, United States

Location

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States

Location

UM Sylvester Comprehensive Cancer Center at Hollywood

Hollywood, Florida, 33021, United States

Location

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States

Location

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States

Location

UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176, United States

Location

UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States

Location

Cleveland Clinic-Weston

Weston, Florida, 33331, United States

Location

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

Location

Northside Hospital

Atlanta, Georgia, 30342, United States

Location

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States

Location

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States

Location

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States

Location

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States

Location

Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States

Location

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States

Location

Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States

Location

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States

Location

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States

Location

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States

Location

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States

Location

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States

Location

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States

Location

OSF Saint Joseph Medical Center

Bloomington, Illinois, 61701, United States

Location

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

Location

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

Location

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States

Location

SIH Cancer Institute

Carterville, Illinois, 62918, United States

Location

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

Location

Centralia Oncology Clinic

Centralia, Illinois, 62801, United States

Location

Mount Sinai Hospital Medical Center

Chicago, Illinois, 60608, United States

Location

Northwestern University

Chicago, Illinois, 60611, United States

Location

University of Illinois

Chicago, Illinois, 60612, United States

Location

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States

Location

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States

Location

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

Location

Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States

Location

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

Location

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

Location

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States

Location

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

Location

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States

Location

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States

Location

Hematology Oncology Associates of Illinois-Highland Park

Highland Park, Illinois, 60035, United States

Location

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States

Location

Presence Saint Mary's Hospital

Kankakee, Illinois, 60901, United States

Location

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

Location

AMG Libertyville - Oncology

Libertyville, Illinois, 60048, United States

Location

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

Location

Loyola University Medical Center

Maywood, Illinois, 60153, United States

Location

SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States

Location

Illinois Cancer Specialists-Niles

Niles, Illinois, 60714, United States

Location

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States

Location

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

Location

Radiation Oncology of Northern Illinois

Ottawa, Illinois, 61350, United States

Location

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

Location

OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States

Location

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

Location

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States

Location

Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States

Location

OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States

Location

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

Location

Valley Radiation Oncology

Peru, Illinois, 61354, United States

Location

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

Location

Hematology Oncology Associates of Illinois - Skokie

Skokie, Illinois, 60076, United States

Location

North Shore Medical Center

Skokie, Illinois, 60076, United States

Location

Central Illinois Hematology Oncology Center

Springfield, Illinois, 62702, United States

Location

Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States

Location

Springfield Clinic

Springfield, Illinois, 62702, United States

Location

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

Location

Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States

Location

Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States

Location

Parkview Regional Medical Center

Fort Wayne, Indiana, 46845, United States

Location

Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States

Location

Franciscan Health Mooresville

Mooresville, Indiana, 46158, United States

Location

Reid Health

Richmond, Indiana, 47374, United States

Location

Mary Greeley Medical Center

Ames, Iowa, 50010, United States

Location

McFarland Clinic - Ames

Ames, Iowa, 50010, United States

Location

McFarland Clinic - Boone

Boone, Iowa, 50036, United States

Location

McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States

Location

McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States

Location

McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States

Location

Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States

Location

Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States

Location

Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States

Location

Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701, United States

Location

Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States

Location

Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States

Location

Cancer Center of Kansas-Independence

Independence, Kansas, 67301, United States

Location

University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States

Location

Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States

Location

Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States

Location

Kansas Institute of Medicine Cancer and Blood Center

Lenexa, Kansas, 66219, United States

Location

Minimally Invasive Surgery Hospital

Lenexa, Kansas, 66219, United States

Location

Cancer Center of Kansas-Liberal

Liberal, Kansas, 67905, United States

Location

Cancer Center of Kansas-Manhattan

Manhattan, Kansas, 66502, United States

Location

Cancer Center of Kansas - McPherson

McPherson, Kansas, 67460, United States

Location

Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States

Location

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States

Location

Menorah Medical Center

Overland Park, Kansas, 66209, United States

Location

Saint Luke's South Hospital

Overland Park, Kansas, 66213, United States

Location

Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States

Location

Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States

Location

Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States

Location

Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States

Location

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States

Location

Associates In Womens Health

Wichita, Kansas, 67208, United States

Location

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States

Location

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States

Location

Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States

Location

Wesley Medical Center

Wichita, Kansas, 67214, United States

Location

Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States

Location

Oncology Hematology Care Inc-Crestview

Crestview Hills, Kentucky, 41017, United States

Location

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States

Location

Ochsner Health Center-Summa

Baton Rouge, Louisiana, 70809, United States

Location

Medical Center of Baton Rouge

Baton Rouge, Louisiana, 70816, United States

Location

Ochsner High Grove

Baton Rouge, Louisiana, 70836, United States

Location

Ochsner LSU Health Monroe Medical Center

Monroe, Louisiana, 71202, United States

Location

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States

Location

LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States

Location

Eastern Maine Medical Center

Bangor, Maine, 04401, United States

Location

Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States

Location

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

Location

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

Location

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600, United States

Location

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States

Location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

Location

Bixby Medical Center

Adrian, Michigan, 49221, United States

Location

Hickman Cancer Center

Adrian, Michigan, 49221, United States

Location

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States

Location

Bronson Battle Creek

Battle Creek, Michigan, 49017, United States

Location

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States

Location

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States

Location

Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States

Location

Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126, United States

Location

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

Location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States

Location

OSF Saint Francis Hospital and Medical Group

Escanaba, Michigan, 49829, United States

Location

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States

Location

Corewell Health Farmington Hills Hospital

Farmington Hills, Michigan, 48336, United States

Location

Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States

Location

Hurley Medical Center

Flint, Michigan, 48503, United States

Location

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

Location

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States

Location

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States

Location

William Beaumont Hospital-Grosse Pointe

Grosse Pointe, Michigan, 48230, United States

Location

Allegiance Health

Jackson, Michigan, 49201, United States

Location

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States

Location

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

Location

Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States

Location

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States

Location

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

Location

Mercy Memorial Hospital

Monroe, Michigan, 48162, United States

Location

Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, 48162, United States

Location

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States

Location

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States

Location

Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States

Location

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States

Location

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States

Location

Huron Medical Center PC

Port Huron, Michigan, 48060, United States

Location

Lake Huron Medical Center

Port Huron, Michigan, 48060, United States

Location

Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States

Location

Michigan Cancer Specialists

Roseville, Michigan, 48066, United States

Location

Oakland Colon Rectal Associates

Royal Oak, Michigan, 48067, United States

Location

Cancer Care Associates PC

Royal Oak, Michigan, 48073, United States

Location

Comprehensive Medical Center PLLC

Royal Oak, Michigan, 48073, United States

Location

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States

Location

Hematology Oncology Consultants PC-Royal Oak

Royal Oak, Michigan, 48073, United States

Location

Oakland Medical Group

Royal Oak, Michigan, 48073, United States

Location

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States

Location

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States

Location

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States

Location

Premier Hematology Oncology Care

Sterling Heights, Michigan, 48312, United States

Location

Mitchell Folbe MD PC

Sterling Heights, Michigan, 48314, United States

Location

Munson Medical Center

Traverse City, Michigan, 49684, United States

Location

Michigan Institute of Urology-Town Center

Troy, Michigan, 48084, United States

Location

Claudia BR Herke MD PC

Troy, Michigan, 48085, United States

Location

Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States

Location

Hematology Oncology Consultants PC-Troy

Troy, Michigan, 48098, United States

Location

Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States

Location

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States

Location

University of Michigan Health - West

Wyoming, Michigan, 49519, United States

Location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States

Location

Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States

Location

Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States

Location

Cox Cancer Center Branson

Branson, Missouri, 65616, United States

Location

Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States

Location

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

Location

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States

Location

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States

Location

Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States

Location

Centerpoint Medical Center LLC

Independence, Missouri, 64057, United States

Location

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States

Location

Freeman Health System

Joplin, Missouri, 64804, United States

Location

Mercy Hospital Joplin

Joplin, Missouri, 64804, United States

Location

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States

Location

Heartland Hematology and Oncology Associates Incorporated

Kansas City, Missouri, 64118, United States

Location

Research Medical Center

Kansas City, Missouri, 64132, United States

Location

Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086, United States

Location

Liberty Hospital

Liberty, Missouri, 64068, United States

Location

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States

Location

Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States

Location

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States

Location

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States

Location

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

Location

CoxHealth South Hospital

Springfield, Missouri, 65807, United States

Location

Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109, United States

Location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Mercy Hospital South

St Louis, Missouri, 63128, United States

Location

Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States

Location

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

Location

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

Location

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States

Location

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States

Location

Mercy Hospital Washington

Washington, Missouri, 63090, United States

Location

Community Hospital of Anaconda

Anaconda, Montana, 59711, United States

Location

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

Location

Saint Vincent Healthcare

Billings, Montana, 59101, United States

Location

Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States

Location

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States

Location

Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States

Location

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States

Location

Great Falls Clinic

Great Falls, Montana, 59405, United States

Location

Saint Peter's Community Hospital

Helena, Montana, 59601, United States

Location

Logan Health Medical Center

Kalispell, Montana, 59901, United States

Location

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States

Location

Community Medical Center

Missoula, Montana, 59804, United States

Location

Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123, United States

Location

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118, United States

Location

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

Carson Tahoe Regional Medical Center

Carson City, Nevada, 89703, United States

Location

Cancer and Blood Specialists-Henderson

Henderson, Nevada, 89052, United States

Location

Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States

Location

Comprehensive Cancer Centers of Nevada-Horizon Ridge

Henderson, Nevada, 89052, United States

Location

Las Vegas Cancer Center-Henderson

Henderson, Nevada, 89052, United States

Location

Comprehensive Cancer Centers of Nevada-Southeast Henderson

Henderson, Nevada, 89074, United States

Location

Las Vegas Urology - Green Valley

Henderson, Nevada, 89074, United States

Location

Las Vegas Urology - Pebble

Henderson, Nevada, 89074, United States

Location

Oncology Las Vegas - Henderson

Henderson, Nevada, 89074, United States

Location

Urology Specialists of Nevada - Green Valley

Henderson, Nevada, 89074, United States

Location

Las Vegas Urology - Pecos

Las Vegas, Nevada, 89074, United States

Location

Desert West Surgery

Las Vegas, Nevada, 89102, United States

Location

OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States

Location

University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102, United States

Location

Hope Cancer Care of Nevada

Las Vegas, Nevada, 89103, United States

Location

Cancer and Blood Specialists-Shadow

Las Vegas, Nevada, 89106, United States

Location

Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States

Location

Urology Specialists of Nevada - Central

Las Vegas, Nevada, 89106, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

Las Vegas, Nevada, 89109, United States

Location

Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-San Martin

Las Vegas, Nevada, 89113, United States

Location

Las Vegas Prostate Cancer Center

Las Vegas, Nevada, 89113, United States

Location

Las Vegas Urology - Sunset

Las Vegas, Nevada, 89113, United States

Location

Urology Specialists of Nevada - Southwest

Las Vegas, Nevada, 89113, United States

Location

Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119, United States

Location

Cancer Therapy and Integrative Medicine

Las Vegas, Nevada, 89121, United States

Location

Ann M Wierman MD LTD

Las Vegas, Nevada, 89128, United States

Location

Cancer and Blood Specialists-Tenaya

Las Vegas, Nevada, 89128, United States

Location

Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

Las Vegas, Nevada, 89128, United States

Location

Las Vegas Urology - Cathedral Rock

Las Vegas, Nevada, 89128, United States

Location

Las Vegas Urology - Smoke Ranch

Las Vegas, Nevada, 89128, United States

Location

Oncology Las Vegas - Tenaya

Las Vegas, Nevada, 89128, United States

Location

OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States

Location

Urology Specialists of Nevada - Northwest

Las Vegas, Nevada, 89128, United States

Location

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States

Location

Comprehensive Cancer Centers of Nevada - Town Center

Las Vegas, Nevada, 89144, United States

Location

Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States

Location

Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144, United States

Location

Las Vegas Cancer Center-Medical Center

Las Vegas, Nevada, 89148-2405, United States

Location

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States

Location

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

Las Vegas, Nevada, 89149, United States

Location

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States

Location

University Cancer Center

Las Vegas, Nevada, 89169, United States

Location

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89183, United States

Location

Hope Cancer Care of Nevada-Pahrump

Pahrump, Nevada, 89048, United States

Location

Renown Regional Medical Center

Reno, Nevada, 89502, United States

Location

Saint Mary's Regional Medical Center

Reno, Nevada, 89503, United States

Location

Radiation Oncology Associates

Reno, Nevada, 89509, United States

Location

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States

Location

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States

Location

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States

Location

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States

Location

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

Location

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

Location

Memorial Sloan Kettering Commack

Commack, New York, 11725, United States

Location

Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

Location

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States

Location

North Shore University Hospital

Manhasset, New York, 11030, United States

Location

Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States

Location

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

University of Rochester

Rochester, New York, 14642, United States

Location

Stony Brook University Medical Center

Stony Brook, New York, 11794, United States

Location

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

Location

Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States

Location

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

Location

Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States

Location

AdventHealth Infusion Center Asheville

Asheville, North Carolina, 28803, United States

Location

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

Location

AdventHealth Infusion Center Haywood

Clyde, North Carolina, 28721, United States

Location

AdventHealth Hendersonville

Hendersonville, North Carolina, 28792, United States

Location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

Location

Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States

Location

Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512, United States

Location

Toledo Clinic Cancer Centers-Bowling Green

Bowling Green, Ohio, 43402, United States

Location

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States

Location

Miami Valley Hospital South

Centerville, Ohio, 45459, United States

Location

Oncology Hematology Care Inc-Eden Park

Cincinnati, Ohio, 45202, United States

Location

Oncology Hematology Care Inc-Mercy West

Cincinnati, Ohio, 45211, United States

Location

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States

Location

Oncology Hematology Care Inc-Anderson

Cincinnati, Ohio, 45230, United States

Location

Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States

Location

Oncology Hematology Care Inc-Blue Ash

Cincinnati, Ohio, 45242, United States

Location

Case Western Reserve University

Cleveland, Ohio, 44106, United States

Location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States

Location

Miami Valley Hospital

Dayton, Ohio, 45409, United States

Location

Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States

Location

Miami Valley Hospital North

Dayton, Ohio, 45415, United States

Location

Oncology Hematology Care Inc-Healthplex

Fairfield, Ohio, 45014, United States

Location

Armes Family Cancer Center

Findlay, Ohio, 45840, United States

Location

Blanchard Valley Hospital

Findlay, Ohio, 45840, United States

Location

Orion Cancer Care

Findlay, Ohio, 45840, United States

Location

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States

Location

Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States

Location

Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States

Location

Wayne Hospital

Greenville, Ohio, 45331, United States

Location

Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States

Location

First Dayton Cancer Care

Kettering, Ohio, 45420, United States

Location

Kettering Medical Center

Kettering, Ohio, 45429, United States

Location

Lima Memorial Hospital

Lima, Ohio, 45804, United States

Location

Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, 43537, United States

Location

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center

Maumee, Ohio, 43537, United States

Location

Dayton Physicians LLC-Signal Point

Middletown, Ohio, 45042, United States

Location

Saint Charles Hospital

Oregon, Ohio, 43616, United States

Location

Toledo Clinic Cancer Centers-Oregon

Oregon, Ohio, 43616, United States

Location

Dayton Physicians LLC-Wilson

Sidney, Ohio, 45365, United States

Location

Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States

Location

Springfield Regional Medical Center

Springfield, Ohio, 45504, United States

Location

ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States

Location

Mercy Hospital of Tiffin

Tiffin, Ohio, 44883, United States

Location

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606, United States

Location

Mercy Health - Saint Vincent Hospital

Toledo, Ohio, 43608, United States

Location

University of Toledo

Toledo, Ohio, 43614, United States

Location

Toledo Community Hospital Oncology Program CCOP

Toledo, Ohio, 43617, United States

Location

Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623, United States

Location

Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States

Location

Dayton Physicians LLC - Troy

Troy, Ohio, 45373, United States

Location

Upper Valley Medical Center

Troy, Ohio, 45373, United States

Location

Saint Joseph Warren Hospital

Warren, Ohio, 44484, United States

Location

Fulton County Health Center

Wauseon, Ohio, 43567, United States

Location

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States

Location

Wright-Patterson Medical Center

Wright-Patterson Air Force Base, Ohio, 45433, United States

Location

Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501, United States

Location

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

Location

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States

Location

Saint Alphonsus Cancer Care Center-Baker City

Baker City, Oregon, 97814, United States

Location

Saint Charles Health System

Bend, Oregon, 97701, United States

Location

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States

Location

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States

Location

Bay Area Hospital

Coos Bay, Oregon, 97420, United States

Location

Providence Newberg Medical Center

Newberg, Oregon, 97132, United States

Location

Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States

Location

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

Location

Providence Portland Medical Center

Portland, Oregon, 97213, United States

Location

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

Location

Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States

Location

Geisinger Medical Center

Danville, Pennsylvania, 17822, United States

Location

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States

Location

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States

Location

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

Location

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

Location

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

Location

Community Medical Center

Scranton, Pennsylvania, 18510, United States

Location

AnMed Health Cancer Center

Anderson, South Carolina, 29621, United States

Location

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States

Location

Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States

Location

Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States

Location

Greenville Health System Cancer Institute-Andrews

Greenville, South Carolina, 29601, United States

Location

Saint Francis Hospital

Greenville, South Carolina, 29601, United States

Location

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States

Location

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States

Location

Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States

Location

Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States

Location

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States

Location

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States

Location

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States

Location

Carolina Blood and Cancer Care Associates PA-Lancaster

Lancaster, South Carolina, 29720, United States

Location

Carolina Blood and Cancer Care Associates PA

Rock Hill, South Carolina, 29732, United States

Location

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States

Location

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

Location

Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, 37067, United States

Location

Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204, United States

Location

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States

Location

Parkland Memorial Hospital

Dallas, Texas, 75235, United States

Location

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States

Location

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States

Location

Ben Taub General Hospital

Houston, Texas, 77030, United States

Location

Houston Methodist Hospital

Houston, Texas, 77030, United States

Location

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003, United States

Location

Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720, United States

Location

Farmington Health Center

Farmington, Utah, 84025, United States

Location

Logan Regional Hospital

Logan, Utah, 84321, United States

Location

Intermountain Medical Center

Murray, Utah, 84107, United States

Location

McKay-Dee Hospital Center

Ogden, Utah, 84403, United States

Location

Utah Valley Regional Medical Center

Provo, Utah, 84604, United States

Location

Riverton Hospital

Riverton, Utah, 84065, United States

Location

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States

Location

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States

Location

LDS Hospital

Salt Lake City, Utah, 84143, United States

Location

South Jordan Health Center

South Jordan, Utah, 84009, United States

Location

Saint George Regional Medical Center

St. George, Utah, 84770, United States

Location

Fredericksburg Oncology Inc

Fredericksburg, Virginia, 22401, United States

Location

VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States

Location

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

Location

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States

Location

Cancer Care Center at Island Hospital

Anacortes, Washington, 98221, United States

Location

MultiCare Auburn Medical Center

Auburn, Washington, 98001, United States

Location

Overlake Medical Center

Bellevue, Washington, 98004, United States

Location

Swedish Cancer Institute-Eastside Oncology Hematology

Bellevue, Washington, 98005, United States

Location

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States

Location

Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States

Location

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States

Location

Providence Regional Cancer Partnership

Everett, Washington, 98201, United States

Location

MultiCare Gig Harbor Medical Park

Gig Harbor, Washington, 98335, United States

Location

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States

Location

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States

Location

Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States

Location

PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States

Location

Jefferson Healthcare

Port Townsend, Washington, 98368, United States

Location

MultiCare Good Samaritan Hospital

Puyallup, Washington, 98372, United States

Location

Valley Medical Center

Renton, Washington, 98055, United States

Location

Minor and James Medical PLLC

Seattle, Washington, 98104, United States

Location

Pacific Gynecology Specialists

Seattle, Washington, 98104, United States

Location

Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States

Location

Kaiser Permanente Washington

Seattle, Washington, 98112, United States

Location

Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States

Location

Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States

Location

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States

Location

Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States

Location

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown

Spokane, Washington, 99204, United States

Location

Evergreen Hematology and Oncology PS

Spokane, Washington, 99218, United States

Location

MultiCare Deaconess Cancer and Blood Specialty Center - North

Spokane, Washington, 99218, United States

Location

MultiCare Deaconess Cancer and Blood Specialty Center - Valley

Spokane Valley, Washington, 99216, United States

Location

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, 98405, United States

Location

MultiCare Tacoma General Hospital

Tacoma, Washington, 98405, United States

Location

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States

Location

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States

Location

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902, United States

Location

Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States

Location

Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States

Location

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States

Location

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States

Location

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States

Location

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

Location

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

Location

Holy Family Memorial Hospital

Manitowoc, Wisconsin, 54221, United States

Location

Saint Vincent Hospital Cancer Center at Marinette

Marinette, Wisconsin, 54143, United States

Location

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

Location

Marshfield Medical Center

Marshfield, Wisconsin, 54449, United States

Location

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States

Location

Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, 54154, United States

Location

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States

Location

HSHS Saint Nicholas Hospital

Sheboygan, Wisconsin, 53081, United States

Location

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States

Location

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495, United States

Location

Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States

Location

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States

Location

Rocky Mountain Oncology

Casper, Wyoming, 82609, United States

Location

Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001, United States

Location

Big Horn Basin Cancer Center

Cody, Wyoming, 82414, United States

Location

Billings Clinic-Cody

Cody, Wyoming, 82414, United States

Location

Welch Cancer Center

Sheridan, Wyoming, 82801, United States

Location

Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada

Location

Clinical Research Unit at Vancouver Coastal Health Authority

Vancouver, British Columbia, V5Z 3P1, Canada

Location

QEII Health Sciences Centre/Nova Scotia Health Authority

Halifax, Nova Scotia, B3H 2Y9, Canada

Location

Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada

Location

CIUSSSEMTL-Hopital Maisonneuve-Rosemont

Montreal, Quebec, H1T 2M4, Canada

Location

Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada

Location

Rambam Medical Center

Haifa, 31096, Israel

Location

Shaare Zedek Medical Center

Jerusalem, 91031, Israel

Location

Cancer Center-Metro Medical Center Bayamon

Bayamón, 00959-5060, Puerto Rico

Location

Doctors Cancer Center

Manati, 00674, Puerto Rico

Location

San Juan Community Oncology Group

San Juan, 00917, Puerto Rico

Location

Centro Comprensivo de Cancer de UPR

San Juan, 00927, Puerto Rico

Location

San Juan City Hospital

San Juan, 00936, Puerto Rico

Location

Related Publications (2)

• Litzow MR, Sun Z, Mattison RJ, Paietta EM, Roberts KG, Zhang Y, Racevskis J, Lazarus HM, Rowe JM, Arber DA, Wieduwilt MJ, Liedtke M, Bergeron J, Wood BL, Zhao Y, Wu G, Chang TC, Zhang W, Pratz KW, Dinner SN, Frey N, Gore SD, Bhatnagar B, Atallah EL, Uy GL, Jeyakumar D, Lin TL, Willman CL, DeAngelo DJ, Patel SB, Elliott MA, Advani AS, Tzachanis D, Vachhani P, Bhave RR, Sharon E, Little RF, Erba HP, Stone RM, Luger SM, Mullighan CG, Tallman MS. Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults. N Engl J Med. 2024 Jul 25;391(4):320-333. doi: 10.1056/NEJMoa2312948.

  PMID: 39047240 DERIVED

• Seftel MD. Hyper-CVAD: a regimen for all seasons. Lancet Haematol. 2020 Jul;7(7):e501-e502. doi: 10.1016/S2352-3026(20)30179-4. No abstract available.

  PMID: 32589970 DERIVED

MeSH Terms

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma; Burkitt Lymphoma

Interventions

Stem Cell Transplantation; Specimen Handling; blinatumomab; N,N-dicyclohexyl-isoborneol-10-sulfonamide; Biopsy; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Calcium Dobesilate; auricularum; dexamethasone acetate; dexamethasone 21-phosphate; Etoposide; Leucovorin; Spinal Puncture; Mercaptopurine; azathiopurine; Methotrexate; merphos; pegaspargase; Prednisone; deltacortene; prednylidene; Rituximab; CT-P10; Vincristine; X-Rays; Phantoms, Imaging

Condition Hierarchy (Ancestors)

Leukemia, Lymphoid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Epstein-Barr Virus Infections; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Tumor Virus Infections; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Lymphoma

Intervention Hierarchy (Ancestors)

Cell Transplantation; Cell- and Tissue-Based Therapy; Biological Therapy; Therapeutics; Transplantation; Surgical Procedures, Operative; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Cytodiagnosis; Cytological Techniques; Diagnostic Techniques, Surgical; Phosphoramide Mustards; Nitrogen Mustard Compounds; Mustard Compounds; Hydrocarbons, Halogenated; Hydrocarbons; Organic Chemicals; Phosphoramides; Organophosphorus Compounds; Cytidine; Pyrimidine Nucleosides; Pyrimidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Arabinonucleosides; Nucleosides; Nucleic Acids, Nucleotides, and Nucleosides; Anthracyclines; Naphthacenes; Polycyclic Aromatic Hydrocarbons; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Polycyclic Compounds; Aminoglycosides; Glycosides; Carbohydrates; Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Steroids, Fluorinated; Benzenesulfonates; Benzene Derivatives; Arylsulfonates; Arylsulfonic Acids; Sulfonic Acids; Sulfur Acids; Sulfur Compounds; Podophyllotoxin; Tetrahydronaphthalenes; Naphthalenes; Glucosides; Formyltetrahydrofolates; Tetrahydrofolates; Folic Acid; Pterins; Pteridines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Coenzymes; Enzymes and Coenzymes; Diagnostic Techniques, Neurological; Punctures; Sulfhydryl Compounds; Purines; Aminopterin; Pregnadienediols; Antibodies, Monoclonal, Murine-Derived; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Serum Globulins; Globulins; Vinca Alkaloids; Secologanin Tryptamine Alkaloids; Indole Alkaloids; Alkaloids; Indoles; Indolizidines; Indolizines; Electromagnetic Radiation; Electromagnetic Phenomena; Magnetic Phenomena; Physical Phenomena; Radiation; Radiation, Ionizing; Equipment and Supplies

Results Point of Contact

• Title: Study Statistician
• Organization: ECOG-ACRIN Statistical Office

eatrials@jimmy.harvard.edu

617-632-3012

Study Officials

• Mark R Litzow

  ECOG-ACRIN Cancer Research Group

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restriction Type: LTE60
• Restrictive Agreement: Yes

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2013
• First Posted: December 6, 2013
• Study Start: May 19, 2014
• Primary Completion: June 23, 2023
• Study Completion (Estimated): February 25, 2027
• Last Updated: May 1, 2026
• Results First Posted: September 24, 2024

Record last verified: 2026-03

Locations

US (532); IL (2); PR (5); CA (6)