Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

NCT04533204 | Completed Results

• 1 other identifier: B6366-W-1
• Study Type: interventional
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

Conditions

Mild Cognitive Impairment

Keywords

MCI; cognitive training; memory training; dementia; Alzheimer's disease

Outcome Measures

Primary Outcomes (1)

• Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment

  Change in memory for 45 trained object location associations

  up to 1 month after last training session

Secondary Outcomes (1)

• Change in Accuracy (vs. Baseline) on Novel Object Location Associations

  up to 1 month after last training session

Study Arms (2)

Mnemonic strategy training

EXPERIMENTAL

Training using mnemonic strategies

Behavioral: mnemonic strategy training

Spaced retrieval training

ACTIVE COMPARATOR

Training using spaced retrieval

Behavioral: spaced retrieval training

Interventions

mnemonic strategy training BEHAVIORAL

training using mnemonic strategies

Mnemonic strategy training

spaced retrieval training BEHAVIORAL

training using spaced retrieval

Spaced retrieval training

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of MCI according to Petersen (2004) criteria, right handed

You may not qualify if:

• Diagnosis of other neurological condition,
• active drug/alcohol abuse/dependence,
• moderate-severe depression or other Axis I diagnoses.

Sponsors & Collaborators

• VA Office of Research and Development: lead

Study Sites (1)

VA Ann Arbor Healthcare System, Ann Arbor, MI

Ann Arbor, Michigan, 48105, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Dementia; Alzheimer Disease

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases

Results Point of Contact

• Title: Dr. Benjamin Hampstead
• Organization: VA Ann Arbor Healthcare System; University of Michigan

bhampste@med.umich.edu

734-763-9259

Study Officials

• Benjamin M. Hampstead, PhD

  VA Ann Arbor Healthcare System, Ann Arbor, MI

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants were informed they would receive one of two cognition oriented treatments but were unaware of the nature of the other intervention.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: FED
• Responsible Party: SPONSOR

Model Details: Randomization to Mnemonic strategy or spaced retrieval training

Study Record Dates

• First Submitted: August 25, 2020
• First Posted: August 31, 2020
• Study Start: August 1, 2010
• Primary Completion: June 30, 2014
• Study Completion: July 30, 2014
• Last Updated: March 23, 2021
• Results First Posted: March 23, 2021

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)