NCT01888991

Brief Summary

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Dec 2011

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2011

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2012

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

June 22, 2013

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 28, 2013

Completed
Last Updated

June 28, 2013

Status Verified

June 1, 2013

Enrollment Period

8 months

First QC Date

June 22, 2013

Last Update Submit

June 25, 2013

Conditions

Food Intake RegulationSubstrate Oxidation

Keywords

GlucoseExerciseMetabolic flexibilitySubstrate OxidationFood intake

Outcome Measures

Primary Outcomes (1)

  • Food Intake

    Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer.

    60 - 90 min in the study

Secondary Outcomes (1)

  • Net Energy Balance

    0-90 min in the study

Study Arms (4)

water with resting condition

NO INTERVENTION

glucose with resting condition

EXPERIMENTAL
Other: Glucose Preload and Exercise Intervention

water with exercise condition

EXPERIMENTAL
Other: Glucose Preload and Exercise Intervention

glucose with exercise condition

EXPERIMENTAL
Other: Glucose Preload and Exercise Intervention

Interventions

Glucose Preload and Exercise InterventionOTHER

A glucose preload and exercise were administered to examine the modulate substrate oxidation

glucose with exercise conditionglucose with resting conditionwater with exercise condition

Eligibility Criteria

Age9 Years - 29 Years
Sexmale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Born at full term
  • Men Age:20-29 years/BMI: 20-25
  • Boys Age 9-11/BMI percentile: 15th to 85th:

You may not qualify if:

  • Smokers
  • Dieters
  • Individuals with lactose intolerance, allergies to milk and dairy products
  • Individuals with gastrointestinal problems
  • Individuals with diabetes or other metabolic diseases
  • Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Nutritional Sciences, University of Toronto

Toronto, Ontario, M5S 3E2, Canada

Location

Related Publications (4)

  • Tamam S, Bellissimo N, Patel BP, Thomas SG, Anderson GH. Overweight and obese boys reduce food intake in response to a glucose drink but fail to increase intake in response to exercise of short duration. Appl Physiol Nutr Metab. 2012 Jun;37(3):520-9. doi: 10.1139/h2012-038. Epub 2012 Apr 25.

    PMID: 22530879BACKGROUND

  • Bellissimo N, Thomas SG, Goode RC, Anderson GH. Effect of short-duration physical activity and ventilation threshold on subjective appetite and short-term energy intake in boys. Appetite. 2007 Nov;49(3):644-51. doi: 10.1016/j.appet.2007.04.004. Epub 2007 Apr 22.

    PMID: 17537539BACKGROUND

  • Bozinovski NC, Bellissimo N, Thomas SG, Pencharz PB, Goode RC, Anderson GH. The effect of duration of exercise at the ventilation threshold on subjective appetite and short-term food intake in 9 to 14 year old boys and girls. Int J Behav Nutr Phys Act. 2009 Oct 9;6:66. doi: 10.1186/1479-5868-6-66.

    PMID: 19818131BACKGROUND

  • Hunschede S, El Khoury D, Antoine-Jonville S, Smith C, Thomas S, Anderson GH. Acute changes in substrate oxidation do not affect short-term food intake in healthy boys and men. Appl Physiol Nutr Metab. 2015 Feb;40(2):168-77. doi: 10.1139/apnm-2014-0188. Epub 2014 Oct 22.

    PMID: 25603432DERIVED

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • Harvey Anderson, Ph.D.

    University of Toronto

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 22, 2013

First Posted

June 28, 2013

Study Start

December 1, 2011

Primary Completion

August 1, 2012

Study Completion

August 1, 2012

Last Updated

June 28, 2013

Record last verified: 2013-06

Locations

CA(1)