NCT01853995

Brief Summary

The aim of the current controlled trial was to assess the possible net skeletal and dental effects of FLMGM treatment in relation to growth with emphasis on the contribution of skeletal and dental changes to sagittal correction of Cl II/1 malocclusion. The null hypothesis stated that there were no significant differences in dentoskeletal changes between FLMGM treated group and control untreated group.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
43

participants targeted

Target at P25-P50 for phase_2

Timeline
Completed

Started May 2009

Typical duration for phase_2

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2009

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2011

Completed
1.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

May 13, 2013

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 15, 2013

Completed
Last Updated

April 17, 2014

Status Verified

March 1, 2014

Enrollment Period

2.2 years

First QC Date

May 13, 2013

Last Update Submit

March 21, 2014

Conditions

Keywords

Fixed Lingual Mandibular Growth Modificator (FLMGM)Class II division 1 malocclusionSagittal Occlusal CorrectionSkeletal changesDental changes

Outcome Measures

Primary Outcomes (1)

  • Overjet reduction and Class II molar correction

    8 months

Secondary Outcomes (1)

  • Total mandibular length (Co-Gn)

    8 months

Other Outcomes (1)

  • Standard Dental and skeletal changes

    8 months

Study Arms (2)

FLMGM Treatment Group

EXPERIMENTAL

Cl II/1 patients treated with Fixed Lingual Mandibular Growth Modificator (FLMGM)

Device: Fixed Lingual Mandibular Growth Modificator (FLMGM)

Untreated Class II Control Group

NO INTERVENTION

control group

Interventions

New Class II Corrector

Also known as: Fixed Lingual Mandibular Growth Modification Appliance
FLMGM Treatment Group

Eligibility Criteria

Age11 Years - 16 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Cl II/1 malocclusion with an overjet greater than 4 mm.
  • Mild to moderate Class II Skeletal pattern (A-N-B \> 4°) with retrognathic mandible (S-N-B \< 76°).
  • Growth potential. Fishman skeletal maturation indicator (SMI) method was used to assess the hand-wrist radiographs, and only patients in the peak of the pubertal growth spurt, which occurs on average between SMIs 4 to 7, at the beginning of the treatment/observation period were invited.

You may not qualify if:

  • craniofacial syndromes
  • clinically obvious facial asymmetry
  • extreme vertical disproportion
  • prior orthodontic therapy
  • permanent tooth extractions
  • significant medical history

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Orthodontics, School of Dentistry, University of Damascus

Damascus, Rif-dimashq Governorate, Syria

Location

MeSH Terms

Conditions

Malocclusion, Angle Class II

Condition Hierarchy (Ancestors)

MalocclusionTooth DiseasesStomatognathic Diseases

Study Officials

  • Osama H Alali, PhD

    Senior Lecturer, Department of Orthodontics, School of Dentistry, University of Aleppo, Syria

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr.

Study Record Dates

First Submitted

May 13, 2013

First Posted

May 15, 2013

Study Start

May 1, 2009

Primary Completion

July 1, 2011

Study Completion

December 1, 2012

Last Updated

April 17, 2014

Record last verified: 2014-03

Locations