NCT01853137

Brief Summary

The current trial was designed to investigate the possible initial net skeletal and dental effects of treatment with FLMGM by a comparative evaluation of treated and untreated Cl II/1 malocclusion subjects. The null hypothesis stated that there were no significant differences in dentofacial changes between FLMGM group and control group.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
43

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started May 2009

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2009

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2011

Completed
1.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

May 10, 2013

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 14, 2013

Completed
7.5 years until next milestone

Results Posted

Study results publicly available

November 12, 2020

Completed
Last Updated

November 12, 2020

Status Verified

October 1, 2020

Enrollment Period

2.2 years

First QC Date

May 10, 2013

Results QC Date

May 14, 2013

Last Update Submit

October 20, 2020

Conditions

Keywords

Class II division 1 malocclusionDentofacial orthopedicsFixed Lingual Mandibular Growth Modificator (FLMGM)

Outcome Measures

Primary Outcomes (1)

  • Total Mandibular Length (Co-Gn)

    8 months

Secondary Outcomes (1)

  • Overjet Reduction

    8 months

Study Arms (2)

FLMGM Treatment Group

EXPERIMENTAL
Device: Fixed Lingual Mandibular Growth Modificator (FLMGM)

Untreated Class II Control Group

NO INTERVENTION

Interventions

Novel Class II functional appliance, a fixed version of double-plate appliance

Also known as: Fixed Lingual Mandibular Growth Modification Appliance (FLMGMA)
FLMGM Treatment Group

Eligibility Criteria

Age11 Years - 16 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Before treatment, each patient fulfilled the following criteria:
  • Cl II/1 malocclusion with an overjet greater than 4 mm.
  • Mild to moderate Class II Skeletal pattern (A-N-B \> 4°) with retrognathic mandible (S-N-B \< 76°).
  • Growth potential. Fishman skeletal maturation indicator (SMI) method28 was used to assess the hand-wrist radiographs, and only patients in the peak of the pubertal growth spurt, which occurs on average between SMIs 4 to 7,29 at the beginning of the treatment/observation period were invited.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Orthodontics, School of Dentistry, University of Damascus

Damascus, Syria

Location

MeSH Terms

Conditions

Malocclusion, Angle Class II

Condition Hierarchy (Ancestors)

MalocclusionTooth DiseasesStomatognathic Diseases

Results Point of Contact

Title
Dr.
Organization
Osama AlAli

Study Officials

  • Osama H Alali, PhD

    Senior Lecturer, Department of Orthodontics, School of Dentistry, University of Aleppo, Syria

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 10, 2013

First Posted

May 14, 2013

Study Start

May 1, 2009

Primary Completion

July 1, 2011

Study Completion

December 1, 2012

Last Updated

November 12, 2020

Results First Posted

November 12, 2020

Record last verified: 2020-10

Locations