Soy Fiber Improves Weight Loss and Lipid Profile

NCT01802840 | Completed DMC

• 1 other identifier: 12-01
• Study Type: interventional
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to examine the effects of soy fiber on body weight, body composition and blood lipids in overweight and obese participants.

Conditions

Obesity; Overweight; Weight Loss

Outcome Measures

Primary Outcomes (1)

• weight loss

  Body weight of participants in soy fiber group was decreased significantly over the study period compared with the baseline.

  12 weeks

Secondary Outcomes (3)

• serum levels of total cholesterol

  12 weeks

• serum levels of low density lipoprotein cholesterol

  12 weeks

• body fat

  12 weeks

Study Arms (2)

biscuits without soy fiber

PLACEBO COMPARATOR

biscuits without soy fiber

Dietary Supplement: biscuits supplemented with soy fiber

biscuits supplemented with soy fiber

EXPERIMENTAL

biscuits supplemented with soy fiber

Dietary Supplement: biscuits supplemented with soy fiber

Interventions

biscuits supplemented with soy fiber DIETARY_SUPPLEMENT

Thirty nine overweight and obese college adults (19-39 y of age) were randomly assigned to consume control biscuits or biscuits supplemented with soy fiber for 12 wk (approximately 100g/d).

biscuits supplemented with soy fiber; biscuits without soy fiber

Eligibility Criteria

• Age: 19 Years - 39 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• BMI of 23-35 kg/m2

You may not qualify if:

• Subjects taking any drugs, botanicals or nutraceutical known to influence body weight or blood pressure
• significant history of eating disorders
• strenuous exercise to lose weight
• lipid-lowering medication
• use of steroids and other agents that may influence lipid metabolism
• hyperlipidemia
• hyperglycemia
• diabetes mellitus
• cardiovascular disease
• major systemic diseases
• gastrointestinal problems
• liver and renal failure

Sponsors & Collaborators

• Zhejiang University: lead

Study Sites (1)

Zhejiang University

Hangzhou, Zhejiang, 310058, China

Location

Related Publications (3)

• Maki KC, Beiseigel JM, Jonnalagadda SS, Gugger CK, Reeves MS, Farmer MV, Kaden VN, Rains TM. Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods. J Am Diet Assoc. 2010 Feb;110(2):205-14. doi: 10.1016/j.jada.2009.10.037.

  PMID: 20102847 BACKGROUND

• Ludwig DS, Pereira MA, Kroenke CH, Hilner JE, Van Horn L, Slattery ML, Jacobs DR Jr. Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA. 1999 Oct 27;282(16):1539-46. doi: 10.1001/jama.282.16.1539.

  PMID: 10546693 BACKGROUND

• Hu X, Gao J, Zhang Q, Fu Y, Li K, Zhu S, Li D. Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial. Mol Nutr Food Res. 2013 Dec;57(12):2147-54. doi: 10.1002/mnfr.201300159. Epub 2013 Jul 23.

  PMID: 23881774 DERIVED

MeSH Terms

Conditions

Obesity; Overweight; Weight Loss

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes

Study Officials

• Duo Li, Prof.

  Zhejiang University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Msd

Study Record Dates

• First Submitted: February 23, 2013
• First Posted: March 1, 2013
• Study Start: March 1, 2012
• Primary Completion: June 1, 2012
• Study Completion: July 1, 2012
• Last Updated: July 7, 2022

Record last verified: 2022-07

Locations

CN (1)