NCT01680315

Brief Summary

The regulation of our food intake is on the short-term guided by appetite and satiety signals generated by the sight and consumption of food. Food intake is not only regulated by appetite and satiety signals - external cues also play an important role. It has been observed that food intake and the pleasure derived from consumption is affected by manipulation of the external cues. The investigators will assess the contribution of food anticipation (calorie information) and actual consumption of a test food (calorie intake) on in satiety responses (such as ghrelin responses, appetite and subsequent food intake). The investigators expect the information on the amount of calories, rather than the actual amount of calories in the food, to predict the ghrelin responses and the subsequent intake of a second meal.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started May 2012

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2012

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2012

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2012

Completed
27 days until next milestone

First Submitted

Initial submission to the registry

August 28, 2012

Completed
10 days until next milestone

First Posted

Study publicly available on registry

September 7, 2012

Completed
Last Updated

September 7, 2012

Status Verified

August 1, 2012

Enrollment Period

2 months

First QC Date

August 28, 2012

Last Update Submit

September 3, 2012

Conditions

Eating BehaviourObesity

Keywords

Satiety,satiation,anticipation,food intake

Outcome Measures

Primary Outcomes (1)

  • Food intake

    60 min (Ad libitum test meal after 1 hr)

Secondary Outcomes (1)

  • Serum concentrations total ghrelin

    60 min (4 samples - every 20 min)

Other Outcomes (2)

  • appetite ratings

    80 min (5 samples - every 20 min)

  • Serum cortisol concentrations

    60 min (4 samples - every 20 min)

Study Arms (2)

Calorie information

EXPERIMENTAL

Low calorie yogurt High calorie yogurt with low calorie information sheet

Behavioral: low calorie yogurtBehavioral: high calorie yogurt

Calorie information (high)

EXPERIMENTAL

Low calorie yogurt High calorie yogurt High calorie information sheet

Behavioral: low calorie yogurtBehavioral: high calorie yogurt

Interventions

low calorie yogurtBEHAVIORAL

all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information)

Calorie informationCalorie information (high)
high calorie yogurtBEHAVIORAL

all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)

Calorie informationCalorie information (high)

Eligibility Criteria

Age18 Years - 35 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • female
  • healthy
  • being used to eat breakfast regularly (≥ 5 times a week).

You may not qualify if:

  • hypersensitivity for the ingredients of the foods under study;
  • lack of appetite; following an energy-restricted diet or change in body weight \> 5 kg; or
  • being a vegan or vegetarian. Participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Uppsala University

Uppsala, 75319, Sweden

Location

Related Publications (1)

  • Hogenkamp PS, Cedernaes J, Chapman CD, Vogel H, Hjorth OC, Zarei S, Lundberg LS, Brooks SJ, Dickson SL, Benedict C, Schioth HB. Calorie anticipation alters food intake after low-caloric not high-caloric preloads. Obesity (Silver Spring). 2013 Aug;21(8):1548-53. doi: 10.1002/oby.20293. Epub 2013 Apr 13.

    PMID: 23585292DERIVED

MeSH Terms

Conditions

Feeding BehaviorObesity

Condition Hierarchy (Ancestors)

Behavior, AnimalBehaviorOverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Pleunie Hogenkamp, PhD

    Uppsala University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 28, 2012

First Posted

September 7, 2012

Study Start

May 1, 2012

Primary Completion

July 1, 2012

Study Completion

August 1, 2012

Last Updated

September 7, 2012

Record last verified: 2012-08

Locations

SE(1)