Intra Cranial EEG Activity During Dexmedetomidine Sedation

NCT01648959 | Terminated Results

• 1 other identifier: 12-0268
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Various parts of the brain are sensitive to various anesthetics.We like to study the effect of dexmedetomidine on the different parts of the brain in patients who are coming for DBS electrode removal under sedation.

Conditions

Complex Partial Seizures

Outcome Measures

Primary Outcomes (1)

• iEEG Recording

  iEEG data from each patient was analyzed using MATLAB (Natick, MA, USA). Data were presented as power spectral density, also referred to as the power spectrum or spectrum which quantifies the frequency distribution of energy or power within a signal. The spectrogram is a time-varying version of the spectrum. In these spectrograms, frequencies are arranged along the y-axis, and time along the x-axis, and power is indicated by color on a decibel (dB) scale. The power spectrum was computed for each channel using The Fast Fourier Transform (FFT). A window length of 20,000 data points was chosen in order to incorporate 4 cycles of a 1 Hz signal. The length of each window was therefore 4 seconds. A Hanning window was used to avoid edge effects of the windowing procedure. The length of the FFT was chosen to be 32768, which is the next power of 2 of the window length. The window overlap was set to zero.

  1 day

Interventions

EEG Recording OTHER

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults between 18 to 80 years of age, who are scheduled for elective removal of intracranial (surface and depth) electrodes under conscious sedation

You may qualify if:

• Adults between 18 to 80 years of age, who are scheduled for elective removal of intracranial (surface and depth) electrodes under conscious sedation

You may not qualify if:

• Lack of informed consent
• Hypersensitivity to dexmedetomidine
• Language barrier
• Emergency surgery

Sponsors & Collaborators

• University Health Network, Toronto: lead

Study Sites (1)

Toronto Western Hospital,UHN.

Toronto, Ontario, M5T2S8, Canada

Location

MeSH Terms

Conditions

Seizures

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Emad Al Azazi
• Organization: Toronto Western Hospital/UHN

emad.alazazi@uhnresearch.ca

416-603-8500

Study Officials

• lashmikumar venkatraghavan, MD

  Assistant professor,Toronto western hospital,university health network (UHN)

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: July 13, 2012
• First Posted: July 25, 2012
• Study Start: July 1, 2012
• Primary Completion: March 1, 2014
• Study Completion: March 1, 2014
• Last Updated: December 22, 2022
• Results First Posted: December 2, 2020

Record last verified: 2022-12

Locations

CA (1)