EEG Measurements to Capture DBS-induced Electric Potentials

NCT07115394 | Recruiting

• 2 other identifiers: 2023-101217-BO-ff_1101116047
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

To measure the electric fields induced by DBS (deep brain stimulation) on the scalp and to improve electric field simulations, the investigators will measure EEG (electroencephalography) measurements with high sampling rates (\>100 kHz). The investigators hypothesize that we can improve electric field simulations of DBS by validating and calibrating the simulations based on EEG measurements at high sampling rates (\>100 kHz).

Conditions

Deep Brain Stimulation; Parkinson's Disease

Keywords

deep brain stimulation; EEG; electric potential

Outcome Measures

Primary Outcomes (1)

• Electric potential at the EEG locations

  The investigators will extract the DBS pulses from the EEG data and check the distribution of the electric potentials as seen in simulations based on individual MRI and CT images. Parameters of the simulation pipeline (e.g. conductances) will be adjusted so that the simulation models fit the data.

  during DBS

Study Arms (1)

EEG measurement during DBS

Different DBS conditions can include the individual bilateral therapeutical DBS settings, unilateral versions of these setting, unilateral single segment use of these settings or unilateral low frequency (15-30 Hz) DBS. EEG measurements with a 4-channel analog EEG amplifier (Digitimer EEG).

Other: EEG recording

Interventions

EEG recording OTHER

EEG will be recorded at high sampling rate

EEG measurement during DBS

Eligibility Criteria

• Age: 35 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients implanted with deep brain stimulation

You may qualify if:

• Provision of written informed consent by the patient
• Age 35 - 85
• patient groups: Parkinson's disease, essential tremor, dystonia
• \>3 months after surgery for DBS

You may not qualify if:

• none.

Sponsors & Collaborators

• Universitätsklinikum Hamburg-Eppendorf: lead
• University of Twente: collaborator

Study Sites (1)

University Medical Center Hamburg-Eppendorf

Hamburg, 20246, Germany

RECRUITING

Central Study Contacts

Bettina C. Schwab, PhD

CONTACT

+49 40 7410 26907; b.schwab@uke.de

Thomas Keizers

CONTACT

t.keizers@utwente.nl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 3, 2025
• First Posted: August 11, 2025
• Study Start: July 11, 2025
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: August 21, 2025

Record last verified: 2025-08

Locations

DE (1)