Brentuximab Vedotin After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

NCT01620229 | Withdrawn Phase 1 DMC

• 4 other identifiers: 2560.00NCI-2012-00924P30CA015704P01CA018029
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This phase I/II trial studies the side effects and best way to give brentuximab vedotin and to see how well it works after donor stem cell transplant in treating patients with hematologic malignancies. Monoclonal antibodies, such as brentuximab vedotin, can block cancer growth in different ways. Some block the ability of cancer to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Monoclonal antibodies may kill cancer cells that are left after donor stem cell transplant.

Conditions

Hematopoietic/Lymphoid Cancer

Outcome Measures

Primary Outcomes (1)

• Incidence of durable hematopoietic engraftment defined as the achievement of > 50% donor CD3+ cell chimerism

  Evaluated according to the allogeneic transplant protocol on which patients are co-enrolled, or according to institutional standard practice if no monitoring scheme is specified in the transplant protocol.

  At day 84 after HCT

Secondary Outcomes (7)

• Rates of relapse

  Up to 5 years

• Non-relapse mortality

  Up to 5 years

• Incidence of acute GVHD

  Up to 5 years

• Peak grade of acute GVHD

  Up to 5 years

• Incidence of chronic GVHD

  Up to 5 years

Study Arms (1)

Treatment (brentuximab vedotin)

EXPERIMENTAL

Patients receive brentuximab vedotin IV on day 1. Treatment repeats every 21 days for up to 16 courses in the absence of disease progression or unacceptable toxicity.

Drug: brentuximab vedotin; Other: laboratory biomarker analysis; Other: pharmacological study

Interventions

brentuximab vedotin DRUG

Given IV

Also known as: Adcetris, anti-CD30 ADC SGN-35, anti-CD30 antibody-drug conjugate SGN-35, antibody-drug conjugate SGN-35, SGN-35

Treatment (brentuximab vedotin)

laboratory biomarker analysis OTHER

Correlative studies

Treatment (brentuximab vedotin)

pharmacological study OTHER

Correlative studies

Also known as: pharmacological studies

Treatment (brentuximab vedotin)

Eligibility Criteria

• Age: 12 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients must have a cluster of differentiation (CD)30+ malignancy, with CD30 positivity demonstrated either at time of original diagnosis or at any subsequent time point
• Patients must have undergone allogeneic HCT from a related or unrelated donor; acceptable donors include:
• Related donors: genotypically or phenotypically identical by serological typing for human leukocyte antigen (HLA)-A, -B, -C, and at the allele level for -DRB1 and -DQB1
• Unrelated donors: Fred Hutchinson Cancer Research Center (FHCRC) matching allowed will be grade 1.0 to 2.1: matched for HLA-A, -B, -C, -DRB1 and -DQB1 by high-resolution typing
• For all donors, a single allele disparity will be allowed for HLA-A, -B, or -C as defined by high-resolution typing
• Patients with HLA-haploidentical donors are not eligible
• Patients must have documented post-transplant donor CD3+ chimerism of \> 50% in sorted peripheral-blood CD3+ cells
• Patients must be at least 28 days out from allogeneic HCT at the time of enrollment; in general, patients should be no more than 60 days out from allogeneic HCT at time of enrollment; however, patients more than 60 days out from allogeneic HCT may be considered for enrollment in discussion with the protocol investigator (Dr. Maloney)
• Patients must be enrolled on an FHCRC non-myeloablative allogeneic transplant protocol (not standard treatment plan); for eligibility purposes, "non-myeloablative" is defined here as conditioning therapy consisting of =\< 4 Gy total body irradiation, with or without fludarabine
• Patients with prior exposure to brentuximab vedotin are eligible for enrollment on this trial, regardless of previous disease response
• Women of childbearing age and men with female partners of childbearing age must be willing and able to use an effective method of contraception during the study and for at least 30 days after the last study dose of brentuximab vedotin
• Patients must be able to give informed consent

You may not qualify if:

• Patients who are seropositive for human immunodeficiency virus (HIV)
• Women who are pregnant or breast-feeding
• Patients with moderate to severe peripheral neuropathy (grade 2 or higher); patients with a history of moderate/severe peripheral neuropathy may be enrolled if their neuropathy improves to =\< grade 1 at the time of enrollment
• Patients with significant hepatic dysfunction, as manifested by a total serum bilirubin \> 4.0 g/dL; or clinical evidence of decompensated hepatic failure; or clinical evidence of decompensated portal hypertension
• Patients with an absolute neutrophil count of \< 1,000 cells/mm\^3
• Patients with Eastern Cooperative Oncology Group (ECOG) performance status of \> 2
• Patients with a serum creatinine \> 3.0 mg/dL
• Patients with known hypersensitivity to brentuximab vedotin or any excipient contained in the drug formulation
• Patients currently receiving treatment with other systemic anti-neoplastic or investigational agents targeting their CD30+ hematologic malignancy
• Patients with active and uncontrolled infection not responding to appropriate treatment should be discussed with the study investigator (Dr. Maloney) before enrollment
• Patients who have received donor lymphocyte infusion for low donor chimerism or pending graft rejection are not eligible

Sponsors & Collaborators

• Fred Hutchinson Cancer Center: lead
• Seagen Inc.: collaborator
• National Cancer Institute (NCI): collaborator

Study Sites (1)

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium

Seattle, Washington, 98109, United States

Location

MeSH Terms

Conditions

Hematologic Neoplasms

Interventions

Brentuximab Vedotin

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases

Intervention Hierarchy (Ancestors)

Oligopeptides; Peptides; Amino Acids, Peptides, and Proteins; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Serum Globulins; Globulins

Study Officials

• David Maloney

  Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 13, 2012
• First Posted: June 15, 2012
• Study Start: June 1, 2013
• Primary Completion: April 1, 2014
• Last Updated: April 21, 2014

Record last verified: 2014-04

Locations

US (1)