A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
SafeHER
A Phase III Prospective, Two-Cohort Non-Randomized, Multi-Centre, Multinational, Open-Label Study to Assess the Safety of Assisted- and Self-Administered Subcutaneous Trastuzumab as Therapy in Patients With Operable HER2-Positive Early Breast Cancer
2 other identifiers
interventional
2,577
55 countries
428
Brief Summary
This multicenter, two-cohort, non-randomized, open-label study will evaluate the safety and tolerability of assisted and self-administered SC Herceptin as adjuvant therapy in participants with early HER2-positive breast cancer following tumor excision. Participants will receive Herceptin 600 milligrams (mg) SC every 3 weeks for 18 cycles, either by an assisted administration using a conventional syringe and needle/vial formulation (Cohort A) or with assisted and self-administration using a single-use injection device (SID) in selected participants (Cohort B).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started May 2012
Longer than P75 for phase_3
428 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 22, 2012
CompletedFirst Posted
Study publicly available on registry
March 29, 2012
CompletedStudy Start
First participant enrolled
May 17, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 10, 2015
CompletedResults Posted
Study results publicly available
April 18, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
February 19, 2020
CompletedApril 27, 2021
April 1, 2021
2.8 years
March 22, 2012
March 6, 2017
April 26, 2021
Conditions
Outcome Measures
Primary Outcomes (7)
Percentage of Participants With At Least 1 Adverse Event (AE) During the Treatment Period
Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. The percentage of participants with at least 1 AE during the treatment period (regardless of severity or seriousness) was reported.
From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
Percentage of Participants With a Grade 3 or Higher AE During the Treatment Period
Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. AEs were graded according to National Cancer Institute Common Terminology Criteria Version 4.0. Grade 3 AEs were those considered severe or medically significant but not immediately life-threatening. Grade 4 AEs were those considered life-threatening and/or for which urgent intervention was indicated. Grade 5 AEs were those resulting in death. The percentage of participants with a Grade 3 or higher (i.e., Grade 3 to 5) AE during the treatment period was reported.
From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
Percentage of Participants With Treatment Interruption Due to an AE
Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. The percentage of participants with SC Herceptin treatment interrupted to assess or treat AEs was reported.
From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
Number of Herceptin Cycles Received
Participants were planned to receive a total of 18 cycles of SC Herceptin. The median number of cycles actually received was reported.
From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
Percentage of Participants by Total Number of Herceptin Cycles Received
Participants were planned to receive a total of 18 cycles of SC Herceptin. The percentage of participants was reported by the total number of cycles actually received. Because the data are presented non-cumulatively, this table reflects participant distribution by the highest number of cycles received.
From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)
Percentage of Participants Who Received Concomitant Cancer Therapy
Concomitant cancer treatment included chemotherapy, radiotherapy, and hormone therapy administered during the study. The percentage of participants who received any of these concomitant therapies was reported.
From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years)
Percentage of Participants Who Received Concomitant Non-Cancer Therapy
Concomitant non-cancer treatment included any pharmacologic interventions administered during the study other than chemotherapy, radiotherapy, or hormone therapy. The percentage of participants who received any concomitant non-cancer therapies was reported.
From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years)
Secondary Outcomes (5)
Percentage of Participants Who Died by Data Cutoff of 10 March 2015
From Baseline to time of event (maximum follow-up approximately 3 years as of data cutoff of 10 March 2015)
Percentage of Participants Who Died During the Safety Follow-up Period
From Baseline to Time of Event, Safety Follow-Up Period (Up to 6 Years)
Disease-Free Survival Rate
From Baseline to time of event (up to approximately 8 years)
Overall Survival Rate
From Baseline to Time of Event (Up to Approximately 6 Years)
Percentage of Participants by Item Response to SID Satisfaction Questionnaire
Cycle 4 (cycle length 3 weeks) and last safety follow-up (LSFU) (approximately 1 year)
Study Arms (2)
Cohort A: SC Herceptin by Needle/Syringe
EXPERIMENTALParticipants will receive SC Herceptin by an assisted administration using a conventional syringe and needle/vial formulation.
Cohort B: SC Herceptin by SID
EXPERIMENTALParticipants will receive SC Herceptin with assisted and/or self-administered use of an SID. The first administration will be performed by a trained healthcare professional. If well tolerated and the participant is willing and judged competent to perform self-administration, subsequent administration of SC Herceptin may be performed by the participant.
Interventions
Herceptin will be given as 600 mg SC (into thigh) on Day 1 of each 3-week cycle for up to 18 cycles.
Eligibility Criteria
You may qualify if:
- Histologically confirmed early invasive HER2-positive carcinoma of the breast with no evidence of residual, locally recurrent, or metastatic disease and defined as clinical Stage I to IIIC that is eligible for treatment with Herceptin
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Screening left ventricular ejection fraction (LVEF) greater than or equal to (≥) 55%
You may not qualify if:
- Previous neoadjuvant or adjuvant breast cancer treatment with an approved or investigational anti-HER2 agent
- History of other malignancy except for curatively treated carcinoma in situ of the cervix, basal cell carcinoma, or curatively treated malignancies (other than breast cancer) where the participant has been disease-free for at least 5 years
- Past history of ductal carcinoma in situ treated with any systemic therapy or with radiation therapy to the ipsilateral breast where invasive cancer subsequently developed
- Metastatic disease
- Inadequate bone marrow, hepatic, or renal function
- Serious cardiac or cardiovascular disease including uncontrolled hypertension or history of hypertensive crisis or hypertensive encephalopathy
- History of severe allergic or immunological reactions, such as difficult-to-control asthma
- Pregnant or lactating women
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (437)
University "Mother Theresa" Hospital Center; Oncology Department
Tirana, 1000, Albania
CPMC; Service d'Oncologie Médicale
Algiers, 16000, Algeria
Fundación CENIT para la Investigación en Neurociencias
Buenos Aires, C1125ABD, Argentina
Hospital Britanico; Oncologia
Buenos Aires, C1280AEB, Argentina
Instituto De Investigaciones Clinicas Zarate
Zárate, 2800, Argentina
Chris O'Brien Lifehouse
Camperdown, New South Wales, 2050, Australia
St George Hospital; Cancer Care Centre
Kogarah, New South Wales, 2217, Australia
Prince of Wales Hospital; Oncology
Randwick, New South Wales, 2031, Australia
Princess Alexandra Hospital; Division of Cancer Services
Woolloongabba, Queensland, 4102, Australia
Queen Elizabeth Hospital; Medical Oncology
Woodville South, South Australia, 5011, Australia
Western Hospital
Footscray, Victoria, 3011, Australia
Peninsula and South Eastern Haematology and Oncology Group
Frankston, Victoria, 3199, Australia
Cabrini Medical Centre; Oncology
Malvern, Victoria, 3144, Australia
Royal Perth Hospital; Department of Medical Oncology
Perth, Western Australia, 6000, Australia
University Clinical Center of the Republic of Srpska
Banja Luka, 78000, Bosnia and Herzegovina
Clinic of Oncology, University Clinical Center Sarajevo
Sarajevo, 7100, Bosnia and Herzegovina
Hospital Sao Rafael - HSR
Salvador, Estado de Bahia, 41253-190, Brazil
Centro de Oncologia da Bahia - CENOB
Salvador, Estado de Bahia, 41820-021, Brazil
Hospital Moinhos de Vento
Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
Hospital Amaral Carvalho
Jaú, São Paulo, 17210-120, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, São Paulo, 01246-000, Brazil
Hospital Perola Byington
São Paulo, São Paulo, 01317-000, Brazil
Complex Oncology Center - Plovdiv First Internal Chemotherapy Department
Plovdiv, 4004, Bulgaria
MHAT Serdika; Department of medical oncology
Sofia, 1303, Bulgaria
SHATOD - Sofia
Sofia, 1784, Bulgaria
Cross Cancer Institute ; Dept of Medical Oncology
Edmonton, Alberta, T6G 1Z2, Canada
British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6, Canada
The Moncton Hospital
Moncton, New Brunswick, E1C 6Z8, Canada
Lakeridge Health Oshawa; Oncology
Oshawa, Ontario, L1G 2B9, Canada
St. Michael'S Hospital
Toronto, Ontario, M5B 1W8, Canada
Windsor Regional Cancer Centre
Windsor, Ontario, N8W 2X3, Canada
CSSS champlain - Charles-Le Moyne
Greenfield Park, Quebec, J4V 2H1, Canada
Mcgill University - Royal Victoria Hospital; Oncology
Montreal, Quebec, H3A 1A1, Canada
Centro Oncológico Antofagasta
Antofagasta, 1240000, Chile
Instituto Nacional del Cancer
Santiago, 8380000, Chile
Sociedad de Investigaciones Medicas Ltda (SIM)
Temuco, 4800827, Chile
Hospital Carlos Van Buren, Servicio de Oncologia
Valparaíso, 2341391, Chile
Clinica del Country
Bogotá, 11001, Colombia
Clínica Imbanaco; Oncology
Cali, Colombia
Clinical Hospital Osijek; Dept For Oncology & Radiotherapy
Osijek, 31000, Croatia
Clinical Hospital Centre Zagreb
Zagreb, 10000, Croatia
Masarykův onkologický ústav; Klinika komplexní onkologické péče
Brno, 656 53, Czechia
Fakultní nemocnice Olomouc
Olomouc, 775 20, Czechia
Fakultní Nemocnice V Motole; Radioterapeuticko-Onkologicke Oddeleni
Prague, 150 06, Czechia
Hospital Metropolitano de Santiago
Santiago de los Caballeros, 51000, Dominican Republic
Instituto de Cáncer SOLCA Cuenca; Oncología
Cuenca, EC010107, Ecuador
Solca Guayaquil- Sociedad de Lucha Contra El Cáncer; Oncology
Guayaquil, EC090112, Ecuador
Hospital Solca Quito; Oncologia
Quito, EC170124, Ecuador
Alexandria Uni ; Medical Oncology
Alexandria, 11737, Egypt
Manial Specialized Hospital; Oncology
Cairo, 11555, Egypt
Nci; Oncology Dept
Cairo, 11796, Egypt
Hospital Oncologia; Oncology
San Salvador, 01101, El Salvador
HOPITAL JEAN MINJOZ; Oncologie
Besançon, 25030, France
Clinique Tivoli; Sce Radiotherapie
Bordeaux, 33000, France
Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie
Bordeaux, 33077, France
Ch De Fleyriat; Pneumologie 1
Bourg-en-Bresse, 01012, France
Hopital Augustin Morvan; Federation De Cancerologie
Brest, 29200, France
Ch De Brive La Gaillarde; Radiotherapie Oncologie
Brive-la-Gaillarde, 19312, France
Clinique Sainte Marie; Chimiotherapie
Chalon-sur-Saône, 71100, France
Fondation Clement Drevon; Oncology
Dijon, 21000, France
Centre Georges-François Lecler; Ctr de Lutte Contre le Canc
Dijon, 21034, France
Ch De La Dracenie; Hopital De Jour
Draguignan, 83007, France
Hopital Prive Drome Ardeche; Chir 2A 2B
Guilherand-Granges, 07500, France
Clinique Sainte Marguerite; Oncologie Medicale
Hyères, 83400, France
CHD Les Oudairies
La Roche-sur-Yon, 85925, France
Hopital Albert Michallon; Oncologie
La Tronche, 38700, France
Ch Du Mans; Medecine Hematologie Oncologie
Le Mans, 72037, France
Clinique Victor Hugo
LeMans, 72000, France
Centre Hartmann
Levallois-Perret, 92300, France
Polyclinique Du Bois; Centre Bourgogne
Lille, 59000, France
Hopital Claude Huriez; Medecine Interne Oncologie
Lille, 59037, France
Ch Bretagne Sud Site Scorff; Oncologie Medicale
Lorient, 56100, France
CH Bretagne Sud Site Bodelio; Oncologie Radiotherapie
Lorient, 56322, France
Ctre Consultations La Sauvegarde
Lyon, 69338, France
Hôpital Saint Joseph; Oncologie Medicale
Marseille, 13285, France
Hopital Clinique Claude Bernard; Oncologie Medicale
Metz, 57000, France
CHRA;Hematologie
Metz-Tessy, 74370, France
Clinique Clementville; Hopital De Jour
Montpellier, 34070, France
Centre Azureen De Cancerologie; Cons externes
Mougins, 06250, France
Centre Antoine Lacassagne; B3 Medecine Conventionnelle
Nice, 06189, France
Hopital Cochin; Unite Fonctionnelle D Oncologie
Paris, 75014, France
Hopital Hotel Dieu; Oncologie Medicale
Paris, 75181, France
HOPITAL TENON; Cancerologie Medicale
Paris, 75970, France
Ch Francois Mitterrand; Medecine Oncologie
Pau, 64046, France
Ch Lyon Sud; Onco Secteur Jules Courmont
Pierre-Bénite, 69495, France
Chp Saint Gregoire; Cancerologie Radiotherapie
Saint-Grégoire, 35768, France
Ico Rene Gauducheau; Oncologie
Saint-Herblain, 44805, France
Clinique de L'Union; Oncologie
Saint-Jean, 31240, France
CMCO De La Cote D Opale; Auberge De Jour
Saint-Martin-Boulogne, 62280, France
Institut de Cancerologie de La Loire; Pneumologie
Saint-Priest-en-Jarez, 42270, France
Ch De Saint Quentin; Medecine B10
Saint-Quentin, 02321, France
Centre Paul Strauss; Oncologie Medicale
Strasbourg, 67065, France
Hopitaux Du Leman Site Thonon; Maternite Gynecologie
Thonon-les-Bains, 74203, France
Institut Claudius Regaud; Departement Oncologie Medicale
Toulouse, 31059, France
Clinique Pasteur; Pneumologie
Toulouse, 31076, France
Clinique Radio Des Dentellieres; Chimiotherapie Radiotherapie
Valenciennes, 59326, France
Centre-Alexis Vautrin
Vandœuvre-lès-Nancy, 54511, France
Klinikum Augsburg; Frauenklinik
Augsburg, 86156, Germany
Internist; Praxis Für Haemotologie & Onkologie
Bad Soden, 65812, Germany
Praxis Dres. Schilling & Till
Berlin, 10317, Germany
Vivantes Klinikum Am Urban; Zentrum für Brusterkrankungen
Berlin, 10967, Germany
Katholische Hospitalvereinigung Ostwestfalen gGmbH
Bielefeld, 33615, Germany
Gemeinschaftspraxis Dr. Bueckner und Dr. Nueckel
Bochum, 44787, Germany
Praxis Dr.med. Katja Ziegler-Löhr
Cologne, 50679, Germany
St. Elisabeth Krankenhaus Köln GmbH; Gynäkologie und Geburtshilfe
Cologne, 50935, Germany
Kliniken der Stadt Köln gGmbH Krankenhaus Holweide; Brustzentrum
Cologne, 51067, Germany
DONAU ISAR Klinikum Deggendorf; Frauenklinik
Deggendorf, 94469, Germany
Universitätsklinikum Essen; Zentrum Für Frauenheilkunde
Essen, 45122, Germany
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum
Essen, 45136, Germany
Universitätsklinikum Freiburg; Frauenklinik
Freiburg im Breisgau, 79106, Germany
Klinikum St. Georg GmbH; Franziskus-Hospital Harderberg; Klinik für Gynaekologie und Geburtshilfe
Georgsmarienhütte, 49124, Germany
Krankenhaus St. Elisabeth und St. Barbara, Klinik für Frauenheilkunde und Geburtshilfe
Halle, 06110, Germany
Universitätsklinikum Hamburg-Eppendorf; Zentrum für operative Medizin Klinik für Gynäkologie
Hamburg, 20246, Germany
Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem
Hamburg, 20357, Germany
Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding
Hanover, 30177, Germany
Medizinische Hochschule Hannover, Klinik für Frauenheilkunde und Geburtshilfe
Hanover, 30625, Germany
Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg
Heidelberg, 69120, Germany
Universitätsklinikum Jena; Klinik und Poliklinik für Frauenheilkunde und Fortpflanzungsmedizin
Jena, 07747, Germany
Elisabeth-Krankenhaus Brustzentrum
Kassel, 34117, Germany
Klinikum Kulmbach; Frauenklinik
Kulmbach, 95326, Germany
Dres. Andreas Köhler und Roswitha Fuchs
Langen, 63225, Germany
Klinikum Leverkusen; Med. Klinik III / Onkologie
Leverkusen, 51375, Germany
Klinikum Ludwigsburg; Klinik für Frauenheilkunde und Geburtshilfe
Ludwigsburg, 71640, Germany
Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe
Lübeck, 23538, Germany
Onkologische Schwerpunktpraxis Lübeck
Lübeck, 23562, Germany
Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde
Mainz, 55131, Germany
Gemeinschaftspraxis Fr. Dr. med. Balser & Hr. Dr. med. Weidenbach
Marburg, 35037, Germany
Klinikum Meiningen Klinik f.Gynäkologie und Geburtshilfe
Meiningen, 98617, Germany
Klinikum Memmingen; Abt.Gynäkologie
Memmingen, 87700, Germany
Mühlenkreiskliniken; Johannes Wesling Klinikum Minden; Klinik für Frauenheilkunde und Geburtshilfe
Minden, 32429, Germany
Praxis Dr.med. Steffi Busch
Mühlhausen, 99974, Germany
Gemeinschaftspraxis Prof. Dr.med. Christoph Salat und Dr.med. Oliver J. Stötzer
München, 80638, Germany
Praxis Dr. Prechtl & Dr. Kowolik; Frauenklinik
München, 81925, Germany
Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe
Münster, 48149, Germany
Ruppiner Kliniken, Klinik fuer Gynaekologie und Geburtshilfe
Neuruppin, 16816, Germany
Klinikum Nord Frauenklinik
Nuremberg, 90419, Germany
Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
Offenbach, 63069, Germany
medius KLINIK OSTFILDERN-RUIT; Brustzentrum
Ostfildern, 73760, Germany
Oncologianova GmbH
Recklinghausen, 45659, Germany
Agaplesion Diakonieklinikum Rotenburg
Rotenburg (Wümme), 27356, Germany
Caritas Klinik St. Theresia -Frauenklinik Brustzentrum
Saarbrücken, 66113, Germany
Leopoldina Krankenhaus der Stadt Schweinfurt GmbH
Schweinfurt, 97422, Germany
HELIOS Klinikum Schwerin; Frauenklinik
Schwerin, 19049, Germany
Johanniter-Krankenhaus Genthin-Stendal; Klinik Für Frauenheilkunde & Geburtshilfe
Stendal, 39576, Germany
Kreiskrankenhaus Torgau; Abt.Gynäkologie und Geburtshilfe
Torgau, 04860, Germany
Universitätsklinik Tübingen; Frauenklinik
Tübingen, 72076, Germany
Katharinen-Hospital gGmbH
Unna, 59423, Germany
GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe
Weinheim, 69469, Germany
ASKLEPIOS KREISKRANKENHÄUSER WEIßENFELS-HOHENMÖLSEN GMBH
Weißenfels, 06667, Germany
Lahn-Dill Kliniken GmbH Klinikum Wetzlar Gynäkologie/Geburtshilfe
Wetzlar, 35578, Germany
Gesellschaft für Medizinische Studien Würselen
Würselen, 52146, Germany
Uni Hospital of Alexandroupoli; Dept. of Oncology - Duth
Alexandroupoli, 681 00, Greece
Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine
Athens, 115 22, Greece
Laiko General Hospital; 1St Pathological Clinic
Athens, 115 27, Greece
Alexandras General Hospital of Athens; Oncology Department
Athens, 115 28, Greece
Periph. University General Hospital of Heraklion Crete; Oncology Department
Heraklion, 711 10, Greece
Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept.
Kifissia, 145 64, Greece
University Hospital of Larissa; Oncology
Larissa, 413 35, Greece
Euromedical General Clinic of Thessaloniki; Oncology Department
Thessaloniki, 546450, Greece
Papageorgiou General Hospital; Medical Oncology
Thessaloniki, 564 29, Greece
Centro Oncológico Sixtino / Centro Oncológico SA
Guatemala City, 01010, Guatemala
Grupo Angeles
Guatemala City, 01015, Guatemala
Queen Elizabeth Hospital; Clinical Oncology
Hong Kong, Hong Kong
Prince of Wales Hosp; Dept. Of Clinical Onc
Shatin, Hong Kong
Szent Margit Hospital; Dept. of Oncology
Budapest, 1032, Hungary
Szent Imre Hospital; Dept. of Oncology
Budapest, 1115, Hungary
Orszagos Onkologiai Intezet
Budapest, 1122, Hungary
Semmelweis Egyetem Aok; Iii.Sz. Belgyogyaszati Klinika
Budapest, 1125, Hungary
Debreceni Egyetem Klinikai Kozpont ; Department of Oncology
Debrecen, 4032, Hungary
Josa Andras Korhaz; Dept of Oncoradiology
Nyíregyháza, 4400, Hungary
Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet
Pécs, 7623, Hungary
Markusovszky Hospital
Szombathely, 9700, Hungary
Hasan Sadikin Hospital; Internal Medicine
Bandung, 40161, Indonesia
CiptoMangunkusumo Hospital; Internal Medicine
Central Jakarta, 10430, Indonesia
Soetomo Hospital; Surgery
East Java, 60286, Indonesia
Dharmais National Cancer Center
Jakarta, 11420, Indonesia
Sardjito Hospital; Instalasi Kanker Tulip
Yogyakarta, 55284, Indonesia
Mater Misericordiae Uni Hospital; Oncology
Dublin, 7, Ireland
Mater Private Hospital
Dublin, 7, Ireland
Beaumont Hospital; Cancer Clinical Trials Unit
Dublin, 9, Ireland
University Hospital Limerick
Limerick, Ireland
Sligo General Hospital; Oncology
Sligo, Ireland
Waterford Regional Hospital; Department Of Medical Oncology
Waterford, Ireland
Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica
Bari, Apulia, 70124, Italy
Ospedale Vito Fazzi; Div. Oncoematologia
Lecce, Apulia, 73100, Italy
IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
San Giovanni Rotondo, Apulia, 71013, Italy
Ospedale Oncologico Regionale; U.O. Oncologia Medica Ed Ematologia
Rionero in Vulture, Basilicate, 85028, Italy
Azienda Ospedaliera A. Cardarelli
Napoli, Campania, 80131, Italy
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica
Napoli, Campania, 80131, Italy
Università degli Studi Federico II; Clinica di Oncologia Medica
Napoli, Campania, 80131, Italy
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, Emilia-Romagna, 47014, Italy
Ospedale Regionale Di Parma; Divisione Di Oncologia Medica
Parma, Emilia-Romagna, 43100, Italy
Az. Osp. Ospedale Civile; U.O. Di Oncologia Medica Ed Ematologia
Piacenza, Emilia-Romagna, 29100, Italy
Azienda USL di Ravenna; Unità Operativa di Oncologia Medica
Ravenna, Emilia-Romagna, 48100, Italy
Ausl Frosinone - Ospedale Umberto I; Divisione Di Oncologia
Frosinone, Lazio, 03100, Italy
IFO - Istituto Regina Elena; Oncologia Medica
Rome, Lazio, 00144, Italy
Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche
Rome, Lazio, 00161, Italy
Azienda Ospedaliera Sant'Andrea
Rome, Lazio, 00189, Italy
Ospedale Belcolle Di Viterbo; Oncologia
Viterbo, Lazio, 01100, Italy
Asst Papa Giovanni XXIII; Oncologia Medica
Bergamo, Lombardy, 24127, Italy
ASST DI CREMONA; Unità di Patologia Mammaria Senologia e Breast Unit
Cremona, Lombardy, 26100, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori; S. C. Oncologia Medica 2
Milan, Lombardy, 20133, Italy
ASST DI MONZA; Oncologia Medica
Monza, Lombardy, 20900, Italy
IRRCCS San Matteo; Dip Oncoematologico ; Divisione Oncologia
Pavia, Lombardy, 27100, Italy
IRCCS Istituto Clinico Humanitas; Oncologia
Rozzano, Lombardy, 20089, Italy
A.O. Città della Salute e della Scienza - Presidio Molinette; divisione oncologia medica
Turin, Piedmont, 10126, Italy
Ospedale Oncologico A.Businco; Div. Oncologia Medica II
Cagliari, Sardinia, 09121, Italy
Ospedale Civile SS Annunziata; oncologia medica
Sassari, Sardinia, 07100, Italy
Ospedale Garibaldi Nesima; Biomedicina Clinica e Molecolare
Catania, Sicily, 95100, Italy
Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1
Florence, Tuscany, 50139, Italy
Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2
Pisa, Tuscany, 56100, Italy
Azienda usl 5 Di Pisa-Ospedale Di Pontedera;U.O. Oncologia
Pontedera, Tuscany, 56025, Italy
Ospedale Civile; Oncologia Medica
Camposampiero, Veneto, 35012, Italy
Arcispedale S.Anna; Oncologia Medica
Cona (Ferrara), Veneto, 44124, Italy
Hospital of Lithuanian University of Health. Sciences Kaunas Clinics
Kaunas, 50009, Lithuania
Klaipeda University Hospital
Klaipėda, 92288, Lithuania
Hospital Wanita dan Kanak-Kanak Sabah
Sabah, Sabah, 88996, Malaysia
Sarawak General Hospital; Department of Radiotherapy, Oncology and Palliative care
Sarawak, Sarawak, 93586, Malaysia
Hospital Pulau Pinang; Jabatan Radioterapi & Onkologi
George Town, 10990, Malaysia
University Malaya Medical Centre; Clinical Oncology Unit,
Kuala Lumpur, 59100, Malaysia
Centro Estatal de Oncología de Campeche
Campeche, 24096, Mexico
Centro Estatal de Cancerología
Chihuahua City, 31000, Mexico
Instituto Nacional de Cancerologia; Oncology
Distrito Federal, 14080, Mexico
Consultorio de Medicina Especializada; Dentro de Condominio San Francisco
Mexico City, 03100, Mexico
Oaxaca Site Management Organization
Oaxaca City, 68000, Mexico
Cancerologia de Queretaro; Oncologia
Queretaro, Queretaro, 76090, Mexico
Centro Estatal de Cancerologia de Nayarit
Tepic, 63170, Mexico
Institut National D'oncologie Sidi Med Benabdellah
Rabat, 6213, Morocco
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, 5223 GZ, Netherlands
Onze Lieve Vrouwe Gasthuis
AC Amsterdam, 1091, Netherlands
Gelre Ziekenhuis Apeldoorn, Lokatie Lukas; Afdeling Interne Geneeskunde
Apeldoorn, 7334 DZ, Netherlands
Rijnstate Ziekenhuis; Inwendige Geneeskunde
Arnhem, 6815 AD, Netherlands
Albert Schweitzer Ziekenhuis - loc Dordrecht
Dordrecht, 3318 AT, Netherlands
Ziekenhuis Gelderse Vallei; Inwendige Geneeskunde
Ede, 6716 RP, Netherlands
Catharina Ziekenhuis; Dept of Internal Medicin
Eindhoven, 5623 EJ, Netherlands
Maxima Medisch Centrum; Inwendige Geneeskunde
Eindhoven, 5631 BM, Netherlands
Martini Ziekenhuis; Dept of Internal Medicine
Groningen, 9728 NT, Netherlands
Atrium Medisch Centrum Parkstad, Heerlen
Heerlen, 6419 PC, Netherlands
Spaarne Ziekenhuis; Inwendige Geneeskunde
Hoofddorp, 2134 TM, Netherlands
St. Antonius Ziekenhuis Nieuwegein
Nieuwegein, 3435 CM, Netherlands
Franciscus Ziekenhuis
Roosendaal, 4708 AE, Netherlands
Maasstad ziekenhuis; Afdeling oncologie hematologie
Rotterdam, 3079 DZ, Netherlands
Ikazia Ziekenhuis
Rotterdam, 3083 AN, Netherlands
Vlietland Ziekenhuis, Locatie Schiedam; Interne Geneeskunde
Schiedam, 3100 AE, Netherlands
Zuyderland ziekenhuis locatie Geleen
Sittard-Geleen, 6162 BG, Netherlands
Diakonessenhuis Utrecht: ziekenhuisapotheek
Utrecht, 3582 KE, Netherlands
Ziekenhuis VieCurie Vitaal
Venlo, 5912 BL, Netherlands
Zaans Medisch Centrum
Zaandam, 1502 DV, Netherlands
Tauranga Hospital, Clinical Trials Unit; BOP Clinical School
Tauranga, 3112, New Zealand
Sørlandet Sykehus Kristiansand
Kristiansand, 4604, Norway
Oslo universitetssykehus HF, Ullevål, Kreftsenteret
Oslo, 0450, Norway
Helse Stavanger HF, Stavanger Universitetssjukehus; Klinikk for Blod og kreftsykdommer
Stavanger, 4011, Norway
Shifa International Hospital; Department of Oncology
Islamabad, 44000, Pakistan
Aga Khan University; Department of Oncology
Karachi, 74800, Pakistan
Shaukat Khanum Memorial Cancer Hospital; Department of Oncology
Lahore, 54000, Pakistan
Hameed Latif Hospital; Department of Oncology
Lahore, 54600, Pakistan
Centro Hemato Oncologico Panama
Panama City, 0832, Panama
Centro Medico Monte Carmelo
Arequipa, 04001, Peru
Instituto Nacional de Enfermedades Neoplasicas
Lima, Lima 34, Peru
Clinica de Especialidades Medicas
Lima, Lima 41, Peru
Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional
Lima, Lima 41, Peru
Instituto Oncologico de Lima
Lima, Lima27, Peru
Philippine General Hospital; Section Of Medical Oncology
Manila, 1000, Philippines
East Avenue Medical Center
Quezon City, 1100, Philippines
Poradnia Onkologiczna oraz Oddzial Kliniczny Onkologii SPZOZ Szpital Uniwersytecki
Krakow, 30-688, Poland
Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii
Otwock, 05-400, Poland
Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu
Poznan, 60-569, Poland
Wielkopolskie Centrum Onkologi
Poznan, 61-866, Poland
MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie
Rzeszów, 35-021, Poland
Wojewodzki Szpital Zespolony
Torun, 87-100, Poland
NZOZ Onko-Dent SP. P. G. L. Slomian, Poradnia Onkologiczna
Żory, 44-240, Poland
Centro Clinico Champalimaud; Oncologia Medica
Lisbon, 1400-038, Portugal
Hospital da Luz; Departamento de Oncologia Medica
Lisbon, 1500-650, Portugal
IPO do Porto; Servico de Oncologia Medica
Porto, 4200-072, Portugal
Hospital de Sao Joao; Servico de Oncologia
Porto, 4200-319, Portugal
Policlinica Sfanta Maria - Oncology; Medical Oncology
Baia Mare, 430241, Romania
Institut of Oncology Al. Trestioreanu Bucharest; Oncology Department
Bucharest, 022328, Romania
Emergency University Bucharest Hospital; Oncology Department
Bucharest, 050098, Romania
Cluj Clinical County Hospital; Oncology Dept
Cluj-Napoca, 400006, Romania
Prof. Dr. I. Chiricuta Institute of Oncology
Cluj-Napoca, 400015, Romania
SC Oncolab SRL
Craiova, 200385, Romania
Clinical Hospital 1 Craiova; Medical Oncology
Craiova, 200642, Romania
S.C. Life Search S.R.L; Medical Oncology Clinic
Timișoara, 300167, Romania
ONCOMED - Medical Centre
Timișoara, 300239, Romania
Regional Oncology Hospital
Irkutsk, 664035, Russia
City Oncological Hospital
Izhevsk, 426009, Russia
Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy
Moscow, 115478, Russia
City Clinical Oncology Hospital
Moscow, 143423, Russia
State Inst. Of Healthcare Orenburg Regional Clinical Oncology Dis
Orenburg, 460021, Russia
City Clinical Oncology Dispensary, SPb SBIH CCOD
Saint Petersburg, 198255, Russia
Bashkirian Republican Clinical Oncology Dispensary
Ufa, 450054, Russia
King Faisal Specialist Hospital & Research Centre
Jeddah, 21499, Saudi Arabia
King Abdul Aziz Medical City, King Fahd National Guard; Oncology
Riyadh, 22490, Saudi Arabia
Clinical Hospital Center Bezanijska kosa; Clinic for Oncology
Belgrade, 11000, Serbia
Institute for Onc/Rad Serbia
Belgrade, 11000, Serbia
Oncology Institute of Vojvodina
Kamenitz, 21204, Serbia
Clinical Center Kragujevac
Kragujevac, 34000, Serbia
Clinical Centre Nis, Clinic for Oncology
Niš, 18000, Serbia
National Cancer Centre; Medical Oncology
Singapore, 169610, Singapore
Mammacentrum sv. Agáty
Banská Bystrica, 974 01, Slovakia
National Cancer Institute - Comenius University; Dept. Clinical Oncology
Bratislava, 811 05, Slovakia
Vychodoslovensky onkologicky ustav
Košice, 040 01, Slovakia
Fakultna nemocnica s poliklinikou J.A. Reimana Presov
Prešov, 081 81, Slovakia
Fakultna nemocnica Trencín; Onkologicke odd.
Trenčín, 911 71, Slovakia
University Medical Centre Maribor; Depart. of Gynecology & Breast Oncology
Maribor, 2000, Slovenia
Westridge Medical Center
Durban, 4058, South Africa
Donald Gordon Medical Centre
Johannesburg, 2193, South Africa
Steve Biko Academic Hospital; Oncology
Pretoria, 0002, South Africa
National Cancer Center
Goyang-si, 10408, South Korea
Samsung Medical Center
Seoul, (0)6351, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Yonsei University Severance Hospital; Medical Oncology
Seoul, 120-752, South Korea
Asan Medical Center.
Seoul, 138-736, South Korea
Hospital General de Elda; Servicio de Oncologia
Elda, Alicante, 03600, Spain
Hospital Universitario Son Espases
Palma de Mallorca, Balearic Islands, 07014, Spain
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
Badalona, Barcelona, 08916, Spain
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
Sabadell, Barcelona, 8208, Spain
Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
Santander, Cantabria, 39008, Spain
IInstituto Oncologico de San Sebastian, Oncologikoa; Servicio de Oncologia
Donostia / San Sebastian, Guipuzcoa, 20014, Spain
Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia
Las Palmas de Gran Canaria, LAS Palmas, 35016, Spain
Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia
Las Palmas de Gran Canaria, LAS Palmas, 35020, Spain
Hospital Quiron de Madrid; Servicio de Oncologia
Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital de Navarra; Servicio de Oncologia
Navarra, Navarre, 31008, Spain
Hospital Do Meixoeiro; Servicio de Oncologia
Vigo, Pontevedra, 36214, Spain
Hospital de Cabueñes; Servicio de Oncologia
Gijón, Principality of Asturias, 33394, Spain
Hospital Universitario de Canarias;servicio de Oncologia
San Cristóbal de La Laguna, Tenerife, 38320, Spain
Complejo Hospitalario Nuestra Señora de la Candelaria; Servicio de Oncologia
Santa Cruz de Tenerife, Tenerife, 38010, Spain
Hospital Lluis Alcanys; Servicio de Oncologia
Xàtiva, Valencia, 46800, Spain
Hospital de Basurto; Servicio de Oncologia
Bilbao, Vizcaya, 48013, Spain
Complejo Hospitalario Universitario de Albacete; Servicio de Oncologia
Albacete, 02006, Spain
Hospital General Univ. de Alicante; Servicio de Oncologia
Alicante, 3010, Spain
Hospital del Mar; Servicio de Oncologia
Barcelona, 08003, Spain
Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
Barcelona, 08041, Spain
Hospital Duran i Reynals; Oncologia
Barcelona, 08907, Spain
Complejo Asistencial Universitario De Burgos; Servicio de Oncologia
Burgos, 09006, Spain
Hospital San Pedro De Alcantara; Servicio de Oncologia
Cáceres, 10003, Spain
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Jaén, 23007, Spain
Complejo Asistencial Universitario de Leon; Servicio de Oncologia
León, 24071, Spain
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia
Lleida, 25198, Spain
Hospital Ramon y Cajal; Servicio de Oncologia
Madrid, 28034, Spain
Hospital Universitario Clínico San Carlos; Servicio de Oncologia
Madrid, 28040, Spain
HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia
Madrid, 28050, Spain
Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia
Murcia, 30120, Spain
Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia
Toledo, 45004, Spain
Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia
Valencia, 46015, Spain
Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
Zaragoza, 50009, Spain
Skånes University Hospital, Skånes Department of Onclology
Lund, 221 85, Sweden
Skaraborgs sjukhus Skoevde, Dept of surgery
Skövde, 54185, Sweden
Hirslanden Medical Center, Tumorzentrum
Aarau, 5000, Switzerland
Kantonsspital Baden; Frauenklinik
Baden, 5405, Switzerland
Ospedale San Giovanni; Oncologia
Bellinzona, 6500, Switzerland
Inselspital Bern; Universitätsklinik für medizinische Onkologie
Bern, 3010, Switzerland
Kantonsspital Frauenfeld, Frauenklinik Thurgau
Frauenfeld, 8501, Switzerland
CHUV; Departement d'Oncologie
Lausanne, 1011, Switzerland
Spital Thun; Medizinische Klinik
Thun, 3600, Switzerland
Kantonsspital Winterthur; Medizinische Onkologie
Winterthur, 8401, Switzerland
Stadtspital Triemli; Frauenklinik
Zurich, 8063, Switzerland
China Medical University Hospital; Surgery
Taichung, 404, Taiwan
National Cheng Kung Uni Hospital; Surgery
Tainan, 704, Taiwan
National Taiwan Uni Hospital; General Surgery
Taipei, 100, Taiwan
Tri-Service General Hospital, Division of General Surgery
Taipei, 114, Taiwan
Department of Surgery, King Chulalongkorn Memorial Hospital
Bangkok, 10330, Thailand
Pramongkutklao Hospital; Medicine - Medical Oncology Unit
Bangkok, 10400, Thailand
Rajvithi Hospital
Bangkok, 10400, Thailand
Ramathibodi Hospital; Medicine/Oncology
Bangkok, 10400, Thailand
Maharaj Nakorn Chiang Mai Hospital; Department of Surgery/Head Neck and Breast Unit; Clinical Trial
Chiang Mai, 50200, Thailand
Oncology Unit, Faculty of Medicine, Vajira Hospital; Department of Medicine
Dusit, 10300, Thailand
Ankara Uni School of Medicine; Medical Oncology
Ankara, 06590, Turkey (Türkiye)
Akdeniz University Medical Faculty; Medical Oncology Department
Antalya, 07070, Turkey (Türkiye)
Dicle University Faculty of Medicine
Diyarbakır, 21280, Turkey (Türkiye)
Gaziantep Univ. Med. Fac.
Gaziantep, 27310, Turkey (Türkiye)
Istanbul Uni of Medicine Faculty; Oncology Dept
Istanbul, 34390, Turkey (Türkiye)
Marmara Uni Faculty of Medicine; Medical Oncology
Istanbul, 34890, Turkey (Türkiye)
Kocaeli University Faculty of Medicine; Medical oncology
İzmit, 31380, Turkey (Türkiye)
Mersin University Medical Faculty
Mersin, 33169, Turkey (Türkiye)
19 Mayis University Medical Faculty; Medical Oncology Department
Samsun, 55139, Turkey (Türkiye)
Hacettepe Uni Medical Faculty Hospital; Oncology Dept
Sihhiye/Ankara, 06230, Turkey (Türkiye)
Kyiv City Clinical Oncological Center; Chemotherapy Department
Kiev, 03115, Ukraine
State Oncology Regional Treatment-Diagnostic Center; Chemotherapy Department
Lviv, 79031, Ukraine
Tawam Hospital
Al Ain City, 15258, United Arab Emirates
Nevill Hall Hospital
Abergavenny, NP7 7EG, United Kingdom
Bedford Hospital; Oncology
Bedford, MK42 9DJ, United Kingdom
Wexham Park Hospital; Oncology
Berkshire, SL2 4HL, United Kingdom
University Hospital Birmingham Queen Elizabeth Hospital
Birmingham, B17 0NH, United Kingdom
Heartlands Hospital; Department Of Medicine
Birmingham, B9 5SS, United Kingdom
Royal Bournemouth Hospital; Oncology
Bournemouth, BH7 7DW, United Kingdom
Kent & Canterbury Hospital
Canterbury, CT1 3NG, United Kingdom
Broomfield Hospital; Oncology
Chelmsford, CM1 7ET, United Kingdom
Glan Clwyd Distr Gen Hospital;Nth Wales Cancer Treatment Ctr
Denbighshire, LL18 5UJ, United Kingdom
Royal Derby Hospital
Derby, DE22 3NE, United Kingdom
North Devon District Hospital
Devon, EX31 4JB, United Kingdom
Russells Hall Hospital; Oncology
Dudley, DY1 2HQ, United Kingdom
University Hospital of North Durham
Durham, DH15TW, United Kingdom
Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN, United Kingdom
Inverclyde Hospital
Greenock, PA16 0XN, United Kingdom
Diana Princess of Wales Hosp.
Grimsby, DN33 2BA, United Kingdom
Royal Surrey County Hospital
Guildford, GU2 7XX, United Kingdom
Princess Alexandra Hospital; Oncology Department
Harlow, CM20 1QX, United Kingdom
Huddersfield Royal Infirmary
Huddersfield, HD3 3EA, United Kingdom
Ipswich Hospital
Ipswich, IP4 5PD, United Kingdom
Crosshouse Hospital; Dept of Oncology
Kilmarnock, KA2 0BE, United Kingdom
Forth Valley Royal Hospital ; Oncology Department
Larbert, FK5 4QE, United Kingdom
Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
St John's Hospital
Livingston, EH54 6PP, United Kingdom
Guys and St Thomas NHS Foundation Trust, Guys Hospital
London, SE1 9RT, United Kingdom
Queen Elizabeth Hospital
London, SE18 4QH, United Kingdom
St George's Hospital
London, SW17 0QT, United Kingdom
Macclesfield District General Hospital
Macclesfield, SK10 3BL, United Kingdom
Christie Hospital; Breast Cancer Research Office
Manchester, M20 4QL, United Kingdom
The Clatterbridge Cancer Ctr For Oncolgy
Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
Freeman Hospital; Northern Centre For Cancer Care
New Castle Upon Tyne, NE7 7DN, United Kingdom
Royal Gwent Hospital
Newport, NP20 2UB, United Kingdom
North Tyneside General Hospital
North Shields, NE29 8NH, United Kingdom
Northampton General Hospital NHS Trust
Northampton, NN1 5BD, United Kingdom
Derriford Hospital; Plymouth Oncology Centre
Plymouth, PL6 8DH, United Kingdom
Poole General Hospital
Poole, BH15 2JB, United Kingdom
Queen Alexandra Hospital, Portsmouth
Portsmouth, PO6 3LY, United Kingdom
Royal Preston Hospital
Preston, PR2 9HT, United Kingdom
Queens Hospital; R&D
Romford, RM7 0AE, United Kingdom
Scarborough General Hospital
Scarborough, YO12 6QL, United Kingdom
Royal Shrewsbury Hospital; Pharmacy Department
Shrewsbury, SY3 8XQ, United Kingdom
Southampton General Hospital
Southampton, SO16 6YD, United Kingdom
Sunderland Royal Hospital
Sunderland, SR4 7TP, United Kingdom
Singleton Hospital; Pharmacy Department
Swansea, SA2 8QA, United Kingdom
Great Western Hospital, Swindon Cancer Research Unit; Osprey Unit Level 3
Swindon, SN3 6BB, United Kingdom
Royal Cornwall Hospital
Truro, TR1 3LQ, United Kingdom
Royal Hampshire County Hospital; Winchester & Andover Breast Unit
Winchester, SO22 5DG, United Kingdom
The Royal Wolverhampton Hospitals NHS Trust
Wolverhampton, WV10 0QP, United Kingdom
Airedale General Hospital; Oncology
York, BD20 6TD, United Kingdom
York District Hospital
York, YO31 8HE, United Kingdom
Grupo Oncológico Cooperativo Uruguayo; Hospital de Clínicas - Dpto. de Oncología
Montevideo, 11400, Uruguay
Hospital Militar; Oncologia
Montevideo, 11600, Uruguay
Hospital Pereira Rossell; Oncology Department
Montevideo, 11600, Uruguay
Instituto Oncológico Luis Razetti
Caracas, 1010, Venezuela
Centro Integral de Oncología
Caracas, 1060, Venezuela
Centro Médico Docente La Trinidad; Unidad de Protocolos Clínicos
Caracas, 1080, Venezuela
K hospital
Hanoi, 100000, Vietnam
Related Publications (2)
Jung KH, Ataseven B, Verrill M, Pivot X, De Laurentiis M, Al-Sakaff N, Lauer S, Shing M, Gligorov J, Azim HA. Adjuvant Subcutaneous Trastuzumab for HER2-Positive Early Breast Cancer: Subgroup Analyses of Safety and Active Medical Conditions by Body Weight in the SafeHer Phase III Study. Oncologist. 2018 Oct;23(10):1137-1143. doi: 10.1634/theoncologist.2018-0065. Epub 2018 Jul 17.
PMID: 30018134DERIVEDGligorov J, Ataseven B, Verrill M, De Laurentiis M, Jung KH, Azim HA, Al-Sakaff N, Lauer S, Shing M, Pivot X; SafeHer Study Group. Safety and tolerability of subcutaneous trastuzumab for the adjuvant treatment of human epidermal growth factor receptor 2-positive early breast cancer: SafeHer phase III study's primary analysis of 2573 patients. Eur J Cancer. 2017 Sep;82:237-246. doi: 10.1016/j.ejca.2017.05.010. Epub 2017 Jun 16.
PMID: 28625777DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Medical Communications
- Organization
- Hoffmann-La Roche
Study Officials
- STUDY DIRECTOR
Clinical Trials
Hoffmann-La Roche
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 22, 2012
First Posted
March 29, 2012
Study Start
May 17, 2012
Primary Completion
March 10, 2015
Study Completion
February 19, 2020
Last Updated
April 27, 2021
Results First Posted
April 18, 2017
Record last verified: 2021-04
Data Sharing
- IPD Sharing
- Will share
Qualified researchers may request access to individual patient level data through the clinical study data request platform (www.clinicalstudydatarequest.com). Further details on Roche's criteria for eligible studies are available here (https://clinicalstudydatarequest.com/Study Sponsors/Study-Sponsors-Roche.aspx). For further details on Roche's Global Policy on Sharing of Clinical Study Information and how to request access to related clinical study documents, see here (https://www.roche.com/research\_and\_development/who\_we\_are\_how\_we\_work/clinical\_trials/our\_commitment\_to\_data\_sharing.htm).