Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
1 other identifier
interventional
67
1 country
1
Brief Summary
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (\> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training. Hypotheses.
- 1.to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program
- 2.to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age
- 3.to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program
- 4.to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2008
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2011
CompletedFirst Submitted
Initial submission to the registry
November 18, 2011
CompletedFirst Posted
Study publicly available on registry
December 12, 2011
CompletedDecember 12, 2011
December 1, 2011
2.8 years
November 18, 2011
December 9, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Skeletal Muscle Protein Synthesis
The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training.
Measured at week 0 (baseline) and week 8
Secondary Outcomes (1)
Mitochondrial Function
Measured at week 0 (baseline) and week 8
Study Arms (3)
Endurance Exercise
EXPERIMENTALParticipants will perform 8-weeks of moderate intensity endurance (cycling) exercise
Resistance Exercise
EXPERIMENTALParticipants will perform 8-weeks of whole-body resistance exercise training.
Control / Combined Training
EXPERIMENTALParticipants will perform 8-weeks of no exercise, followed by an additional 8-weeks of combined endurance plus resistance exercise training.
Interventions
Participants will perform 8-weeks of endurance exercise training. Participants will train 5 days per week for 60 min at 65% of VO2 peak.
Participants will perform 8-weeks of resistance exercise training. Participants will train 4 days per week for \~60 min. Two days will focus on lower body resistance training and two days will focus on upper body.
Participants will perform 8-weeks of no exercise (control), followed by 8-weeks of combined endurance and resistance training. Participants will endurance train 5 days per week for 30 min at 65% of VO2 peak and resistance train 4 days per week for 30 min.
Eligibility Criteria
You may qualify if:
- Healthy
- to 30 or \>65 years
- Males and Females
You may not qualify if:
- Regular Exercise Program
- Smoking
- Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)
- Drugs known to impair metabolic function (beta blockers, steroids)
- Allergies to lidocaine
- Physical disability that precludes exercise
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic
Rochester, Minnesota, 55905, United States
Related Publications (1)
Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS. Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. J Clin Endocrinol Metab. 2015 Apr;100(4):1654-63. doi: 10.1210/jc.2014-3081. Epub 2015 Jan 19.
PMID: 25599385DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
K. Sreekumaran Nair, MD, PD
Mayo Clinic
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Medicine
Study Record Dates
First Submitted
November 18, 2011
First Posted
December 12, 2011
Study Start
May 1, 2008
Primary Completion
February 1, 2011
Study Completion
February 1, 2011
Last Updated
December 12, 2011
Record last verified: 2011-12