Study Stopped
Project has been withdrawn from funding consideration
Resistance Exercise for the Prevention of Age-related Sarcopenia
REPAiRS
Negative Work Exercise as a Novel Treatment for Sarcopenia in Older Men
1 other identifier
interventional
N/A
1 country
1
Brief Summary
The purpose of this study is to determine the benefits of negative work progressive resistance exercise (PRE) for the conservative management of sarcopenia in older male Veterans at the DC VAMC. Efficacy will be assessed by examining post-exercise changes in metabolic and inflammatory markers, muscle morphology, strength, and functional status.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Jun 2011
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 14, 2011
CompletedFirst Posted
Study publicly available on registry
May 18, 2011
CompletedStudy Start
First participant enrolled
June 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2014
CompletedJune 26, 2015
June 1, 2015
3 years
March 14, 2011
June 25, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Changes in insulin sensitivity following the exercise intervention as estimated with the QUICKI algorithm (quantitative insulin sensitivity check index)
Blood tests will be obtained after a 12- hour overnight fast at baseline, weeks 6, week 12 and week 24: glucose and insulin values will be determined before and during a standard (75 g) 2 hour oral glucose tolerance test (to determine insulin sensitivity via QUICKI algorithm.
Change from baseline in QUICKI values at week 6, week 12, and week 24
Secondary Outcomes (2)
Peak isokinetic torque
Treatment weeks: 1, 6, and 12; post-treatment weeks: 6 and 12
Diagnostic ultrasongraphy
Treatment weeks: 1, 6, and 12; post-treatment weeks: 6 and 12
Study Arms (2)
1
EXPERIMENTALExercise group 1: Negative work exercise
2
OTHERExercise group 2: Negative work exercise (delayed start for single-arm crossover trial)
Interventions
Submaximal negative work exercise using an isokinetic dynamometer will be performed twice per week for 12 weeks. Exercise volume will be 3 sets of 10 repetitions for the knee and shoulder extensors.
Eligibility Criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
VA Medical Center, DC
Washington D.C., District of Columbia, 20422, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Michael Harris-Love, DSc MPT BS
VA Medical Center, DC
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- FED
Study Record Dates
First Submitted
March 14, 2011
First Posted
May 18, 2011
Study Start
June 1, 2011
Primary Completion
June 1, 2014
Study Completion
June 1, 2014
Last Updated
June 26, 2015
Record last verified: 2015-06