Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men

NCT01062711 | Completed

• 1 other identifier: DMI 1484
• Study Type: interventional
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e. performing resistance exercise) and proper nutrition, in particular eating enough high quality protein, can help slow the loss of muscle mass or potentially even reverse it. Protein and resistance exercise are thought to do this by stimulating your muscle to make more proteins and/or potentially by slowing down the rate at which your body breaks proteins down. Whey protein is a high quality protein isolated from milk and is known to stimulate new protein synthesis for all proteins in your body. However, to date, the effect that whey protein has on muscle protein synthesis, particularly in the elderly has yet to be determined. Thus the purposes of this study are: 1) to determine if whey is an effective source of protein that will stimulate muscle protein synthesis in the elderly, similar to what we have previously seen in young persons; 2) to determine the smallest amount of whey protein to consume to maximally stimulate your muscle to make new proteins; 3) to see if performing resistance exercise will augment the increase in new muscle protein synthesis with whey consumption; and 4) to try and found out if whey is more effective than soy protein in stimulating new muscle protein synthesis and suppressing muscle protein breakdown in the elderly, similar to what we have previously seen in young persons

Conditions

Sarcopenia

Keywords

sarcopenia; muscle; protein; muscle protein synthesis; muscle protein breakdown; whey; soy; casein; dose response; resistance exercise; unilateral; knee extension; whole body protein

Outcome Measures

Primary Outcomes (2)

• Muscle protein synthesis

  Acute within the day

• whole body amino acid oxidation

  acute within the day

Secondary Outcomes (3)

• muscle protein breakdown

  Acute within the day

• serum insulin

  acute within the day

• plasma amino acid concentrations

  acute within the day

Study Arms (7)

Control group 0 g protein

OTHER

Control group in which a placebo drink containing no protein is given following unilateral knee extension exercise

Dietary Supplement: Whey or soy protein

10g whey

EXPERIMENTAL

10g whey protein given following unilateral knee extension exercise

Dietary Supplement: Whey or soy protein

20g whey

EXPERIMENTAL

20g whey protein given following unilateral knee extension exercise

Dietary Supplement: Whey or soy protein

30g whey

EXPERIMENTAL

30g whey protein given following unilateral knee extension exercise

Dietary Supplement: Whey or soy protein

40g whey

EXPERIMENTAL

40g whey protein given following unilateral knee extension exercise

Dietary Supplement: Whey or soy protein

20g soy

EXPERIMENTAL

20g soy protein given following unilateral knee extension exercise

Dietary Supplement: Whey or soy protein

40g soy

EXPERIMENTAL

40g soy protein given following unilateral knee extension exercise

Dietary Supplement: Whey or soy protein

Interventions

Whey or soy protein DIETARY_SUPPLEMENT

Whey and casein are isolated milk proteins

10g whey; 20g soy; 20g whey; 30g whey; 40g soy; 40g whey; Control group 0 g protein

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male
• Aged 60 to 80 years old
• Non-smoker
• Generally healthy and can tolerate the resistance exercise and protein drink

You may not qualify if:

• Allergies to whey, casein or soy
• Health problems such as: heart disease, rheumatoid arthritis of the knee joint, diabetes, poor lung function, uncontrolled hypertension, or any health conditions that might put participants at risks for this study
• Failed clearance for exercise participation by their medical doctor
• Failed an exercise stress test
• Taking metformin and/or other medications for the control of blood glucose even though one might not be classified as diabetic
• Taking prescribed blood thinners such as warfarin and heparin but excluding aspirin
• Taking medications for lung and kidney conditions but excluding medication for asthma that is under control

Sponsors & Collaborators

• McMaster University: lead
• National Dairy Council: collaborator

Study Sites (1)

McMaster University

Hamilton, Ontario, L8S 4K1, Canada

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Whey; Soybean Proteins

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Milk; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Dairy Products; Food; Food and Beverages; Plant Proteins; Proteins; Amino Acids, Peptides, and Proteins; Plant Proteins, Dietary; Dietary Proteins; Soy Foods; Vegetable Products; Vegetables

Study Officials

• Stuart Phillips, Ph.D.

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 3, 2010
• First Posted: February 4, 2010
• Study Start: July 1, 2008
• Primary Completion: December 1, 2010
• Study Completion: May 1, 2011
• Last Updated: July 20, 2011

Record last verified: 2011-07

Locations

CA (1)