NCT01442415

Brief Summary

Childhood cancer survivors (CCS) are prone to develop obesity and are at increased risk of developing cardiovascular disease and type 2 diabetes compared to the general pediatric population. Few lifestyle modification trials have been conducted in overweight/obese CCS and it is unclear whether CCS respond similarly to lifestyle modification compared to overweight/obese individuals who have not had cancer (non-CCS). We propose a 3-year pilot study that will enroll separate cohorts of overweight/obese CCS and overweight/obese non-CCS every September into a family-based lifestyle modification program consisting of weekly sessions at the University of Minnesota. The goal of the program will be to facilitate improved physical fitness, weight management, heart health, and quality of life.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2011

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 30, 2011

Completed
29 days until next milestone

First Posted

Study publicly available on registry

September 28, 2011

Completed
3 days until next milestone

Study Start

First participant enrolled

October 1, 2011

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2012

Completed
Last Updated

October 24, 2012

Status Verified

October 1, 2012

Enrollment Period

1 year

First QC Date

August 30, 2011

Last Update Submit

October 22, 2012

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Peak VO2 at 10 Weeks

    Change in level of physical fitness

    10 week

Secondary Outcomes (3)

  • Change in BMI at 10 Weeks

    10 week

  • Change in Systolic Blood Pressure at 10 Weeks

    10 week

  • Change in Waist Circumference at 10 Weeks

    10 week

Study Arms (1)

Lifestyle Modification

OTHER

Weekly 2 hour study sessions for 10 weeks; each session includes one hour of physical activity and one hour of dietary counseling

Behavioral: Lifestyle modification

Interventions

Weekly lifestyle modification sessions including dietary counseling and physical activity

Lifestyle Modification

Eligibility Criteria

Age8 Years - 16 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Survivor of childhood cancer for ≥5 years (N = 24) and no history of childhood cancer (N = 24)
  • Age 8-16 years old at the time of consent
  • BMI ≥ 85th percentile or waist circumference ≥ 85th percentile for age and gender

You may not qualify if:

  • Exercise/physical activity contraindicated
  • Initiation of a new drug therapy within the past 30 days prior to study commencement
  • Current (within 3 months of study commencement) use of weight loss medication(s)
  • History of weight loss surgery
  • Obesity from a genetic cause (e.g., Prader-Willi)
  • Central nervous system injury or severe neurological impairment
  • Known systolic or diastolic dysfunction or heart failure

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

MeSH Terms

Conditions

OverweightObesity

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Aaron S. Kelly, Ph.D.

    University of Minnesota

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 30, 2011

First Posted

September 28, 2011

Study Start

October 1, 2011

Primary Completion

October 1, 2012

Study Completion

October 1, 2012

Last Updated

October 24, 2012

Record last verified: 2012-10

Locations