Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)
CANTOS
A Randomized, Double-blind, Placebo-controlled, Event-driven Trial of Quarterly Subcutaneous Canakinumab in the Prevention of Recurrent Cardiovascular Events Among Stable Post-myocardial Infarction Patients With Elevated hsCRP
2 other identifiers
interventional
10,066
37 countries
1112
Brief Summary
Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated hsCRP could prevent recurrent cardiovascular events. The purpose of the extension phase of the main study is to collect additional long-term safety data on continued exposure to canakinumab in patients who participated in the pivotal phase. Sub-study 1 (CACZ885M2301S1): The purpose of this sub-study was to evaluate the effect of quarterly subcutaneous canakinumab treatment for 24 months comparted with placebo on the carotid plaque burden measured by integrated vascular MRI in patients enrolled in the CACZ885M2301 study (CANTOS). Sub-study 2 (CACZ885M2301S2): The purpose of this CANTOS sub-study was to determine whether, in patients with type 2 diabetes participating in the CANTOS main study, canakinumab compared to placebo, on top of standard of care could increase insulin secretion and insulin sensitivity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Apr 2011
Longer than P75 for phase_3
1112 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 29, 2011
CompletedFirst Posted
Study publicly available on registry
April 4, 2011
CompletedStudy Start
First participant enrolled
April 11, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 28, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
April 14, 2019
CompletedResults Posted
Study results publicly available
January 22, 2020
CompletedJanuary 22, 2020
January 1, 2020
6 years
March 29, 2011
November 25, 2019
January 10, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Analysis of Core Phase First CEC Confirmed Major Adverse Cardiovascular Events (MACE) and Its Components
Time to occurrence of CEC (Cardiovascular clinical events adjudication committee) confirmed MACE, which was a composite endpoint consisting of CEC confirmed CV death, CEC confirmed non-fatal MI,or CEC confirmed non-fatal stroke. Patients with the CEC adjudicated reason for death of "Unknown" were counted as CV (cardiovascular) death.
From randomization, to end of treatment plus 30 days, up to approximately 6 years
Substudy 1 (Core Phase): Change From Baseline in Carotid Plaque Burden in the Bifurcation Region of the Index Carotid Artery
24 months
Substudy 2 (Core Phase): Change From Baseline of the Insulin Secretion Rate (ISR) Relative to Glucose 0-30 Min Defined as Φ30 = AUCISR 0-30 / AUCGluc 0-30 Averaged Across the Year 3, 4, 5 Visits
From randomization up to approximately 6 years
Secondary Outcomes (14)
Patients With Core Phase CEC Confirmed CV Death, Non-fatal MI, Non-fatal Stroke, or Hospitalization for Unstable Angina Requiring Unplanned Revascularization
From randomization, to end of treatment pus 30 days, up to approximately 6 years
Patients With Core Phase New Onset Type 2 Diabetes Among Patients With Pre-diabetes at Randomization
From randomization up to approximately 6 years
Core Phase All-cause Mortality, Non-fatal MI, or Non-fatal Stroke
From randomization, to end of treatment plus 30 days, up to approximately 6 years
Core Phase All-cause Mortality
From randomization, to end of treatment plus 30 days, up to approximately 6 years
Summary of Adverse Events (Core Phase)
From randomization, to end of treatment plus 30 days, up to approximately 6 years
- +9 more secondary outcomes
Study Arms (4)
Canakinumab Dose 50 mg
EXPERIMENTALPivotal Phase: Blinded Canakinumab 50 mg quarterly subcutaneous + standard of care therapy. Extension Phase: Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Canakinumab Dose 150 mg
EXPERIMENTALPivotal Phase: Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Canakinumab Dose 300 mg
EXPERIMENTALPivotal Phase: Blinded Canakinumab 300 mg quarterly subcutaneous (with one additional dose at week 2) + standard of care therapy. Extension phase: Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Placebo
PLACEBO COMPARATORPivotal Phase: Blinded matching placebo quarterly subcutaneous + standard of care therapy. Extension Phase: Switched to open-label Canakinumab 150 mg quarterly subcutaneous + standard of care therapy
Interventions
Standard of care post-MI background therapy includes, but is not limited to, lipid lowering, anti-hypertensive, beta blockers, and anti-platelet therapy as appropriate
Eligibility Criteria
You may qualify if:
- Written informed consent
- Male, or Female of non-child-bearing potential
- Age ≥ 18 years.
- Spontaneous MI at least 30 days before randomization. hsCRP ≥ 2 mg/L
- Acquisition of evaluable baseline MRI images of bilateral carotid arteries by the imaging core laboratory
- T2D at baseline per Main protocol criteria and be on a stable anti-hyperglycemic medication for at least 4 weeks prior to the baseline OGTT test
- Willing to have the OGTT assessment started before 10 am
You may not qualify if:
- Pregnant or nursing (lactating) women
- Women of child-bearing potential
- Any of the following concomitant diseases
- Planned coronary revascularization (PCI or CABG)
- Major non-cardiac surgical or endoscopic procedure within past 6 months
- Multi-vessel CABG surgery within the past 3 years
- Symptomatic patients with Class IV heart failure (HF) (New York Heart Association \[NYHA\].
- Uncontrolled hypertension
- Uncontrolled diabetes
- Patients with prior history of carotid angioplasty, stenting, or carotid atherectomy
- Patients with contraindications to MRI examination (brain aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker, pacemaker wires or defibrillator, prosthetic heart valves, cochlear implant, ocular foreign body or other implanted body, tattoos, implanted insulin pump, metal shrapnel or bullet)
- Patients prone to claustrophobia or known anxiety disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1131)
Novartis Investigative Site
Athens, Alabama, 35611, United States
Novartis Investigative Site
Birmingham, Alabama, 35235-3424, United States
Novartis Investigative Site
Birmingham, Alabama, 35243, United States
Novartis Investigative Site
Birmingham, Alabama, 35294-2041, United States
Novartis Investigative Site
Fairhope, Alabama, 36532, United States
Novartis Investigative Site
Huntsville, Alabama, 35801, United States
Novartis Investigative Site
Mobile, Alabama, 36604, United States
Novartis Investigative Site
Mobile, Alabama, 36608, United States
Novartis Investigative Site
Mobile, Alabama, 36617-2293, United States
Novartis Investigative Site
Anchorage, Alaska, 99508, United States
Novartis Investigative Site
Chandler, Arizona, 85224, United States
Novartis Investigative Site
Glendale, Arizona, 85306, United States
Novartis Investigative Site
Phoenix, Arizona, 85018, United States
Novartis Investigative Site
Phoenix, Arizona, 85032, United States
Novartis Investigative Site
Hot Springs, Arkansas, 71913, United States
Novartis Investigative Site
Jonesboro, Arkansas, 72401, United States
Novartis Investigative Site
Little Rock, Arkansas, 72204, United States
Novartis Investigative Site
Beverly Hills, California, 90211, United States
Novartis Investigative Site
Carmichael, California, 95608, United States
Novartis Investigative Site
Escondido, California, 92025, United States
Novartis Investigative Site
Fullerton, California, 92835, United States
Novartis Investigative Site
Huntington Beach, California, 92647, United States
Novartis Investigative Site
Lancaster, California, 93534, United States
Novartis Investigative Site
Loma Linda, California, 92354, United States
Novartis Investigative Site
Loma Linda, California, 92357, United States
Novartis Investigative Site
Long Beach, California, 90806, United States
Novartis Investigative Site
Los Angeles, California, 90033, United States
Novartis Investigative Site
Los Angeles, California, 90073, United States
Novartis Investigative Site
Los Gatos, California, 95032, United States
Novartis Investigative Site
Mission Viejo, California, 92691, United States
Novartis Investigative Site
Newport Beach, California, 92663, United States
Novartis Investigative Site
Northridge, California, 91325, United States
Novartis Investigative Site
Oceanside, California, 92056, United States
Novartis Investigative Site
Orangevale, California, 95662, United States
Novartis Investigative Site
Palm Springs, California, 92262, United States
Novartis Investigative Site
Pasadena, California, 91105, United States
Novartis Investigative Site
Pomona, California, 91767, United States
Novartis Investigative Site
Sacramento, California, 95816, United States
Novartis Investigative Site
Sacramento, California, 95819, United States
Novartis Investigative Site
San Diego, California, 92101, United States
Novartis Investigative Site
San Diego, California, 92120, United States
Novartis Investigative Site
San Diego, California, 92128, United States
Novartis Investigative Site
San Diego, California, 92161, United States
Novartis Investigative Site
San Francisco, California, 94143-0792, United States
Novartis Investigative Site
Santa Ana, California, 92704, United States
Novartis Investigative Site
Santa Rosa, California, 95405, United States
Novartis Investigative Site
Torrance, California, 90502, United States
Novartis Investigative Site
Tustin, California, 92780, United States
Novartis Investigative Site
Visalia, California, 93291, United States
Novartis Investigative Site
Walnut Creek, California, 94598, United States
Novartis Investigative Site
Aurora, Colorado, 80012, United States
Novartis Investigative Site
Colorado Springs, Colorado, 80907, United States
Novartis Investigative Site
Denver, Colorado, 80204-4507, United States
Novartis Investigative Site
Denver, Colorado, 80206, United States
Novartis Investigative Site
Denver, Colorado, 80218, United States
Novartis Investigative Site
Denver, Colorado, 80220, United States
Novartis Investigative Site
Norwich, Connecticut, 06360, United States
Novartis Investigative Site
Newark, Delaware, 19713, United States
Novartis Investigative Site
Washington D.C., District of Columbia, 20010, United States
Novartis Investigative Site
Washington D.C., District of Columbia, 20037, United States
Novartis Investigative Site
Clearwater, Florida, 33756, United States
Novartis Investigative Site
Coral Springs, Florida, 33065, United States
Novartis Investigative Site
Davie, Florida, 33324, United States
Novartis Investigative Site
Daytona Beach, Florida, 32114, United States
Novartis Investigative Site
DeFuniak Springs, Florida, 32435, United States
Novartis Investigative Site
Doral, Florida, 33136, United States
Novartis Investigative Site
Hialeah, Florida, 33012, United States
Novartis Investigative Site
Hollywood, Florida, 33021, United States
Novartis Investigative Site
Hollywood, Florida, 33312, United States
Novartis Investigative Site
Jacksonville, Florida, 32204, United States
Novartis Investigative Site
Jacksonville, Florida, 32209-6511, United States
Novartis Investigative Site
Jacksonville, Florida, 32216, United States
Novartis Investigative Site
Jacksonville, Florida, 32223, United States
Novartis Investigative Site
Jacksonville Beach, Florida, 32050, United States
Novartis Investigative Site
Jupiter, Florida, 33458, United States
Novartis Investigative Site
Miami, Florida, 33126, United States
Novartis Investigative Site
Miami, Florida, 33135, United States
Novartis Investigative Site
Miami, Florida, 33155, United States
Novartis Investigative Site
Miami, Florida, 33176, United States
Novartis Investigative Site
Miami Beach, Florida, 33140, United States
Novartis Investigative Site
Naples, Florida, 34119, United States
Novartis Investigative Site
Orlando, Florida, 32822, United States
Novartis Investigative Site
Pembroke Pines, Florida, 33024, United States
Novartis Investigative Site
Pinellas Park, Florida, 33781, United States
Novartis Investigative Site
Port Charlotte, Florida, 33952, United States
Novartis Investigative Site
Port Orange, Florida, 32127, United States
Novartis Investigative Site
Sarasota, Florida, 34239, United States
Novartis Investigative Site
South Miami, Florida, 33143, United States
Novartis Investigative Site
Tampa, Florida, 33613, United States
Novartis Investigative Site
Tampa, Florida, 33624, United States
Novartis Investigative Site
Wellington, Florida, 33449, United States
Novartis Investigative Site
Athens, Georgia, 30606, United States
Novartis Investigative Site
Augusta, Georgia, 30904, United States
Novartis Investigative Site
Covington, Georgia, 30014, United States
Novartis Investigative Site
Cumming, Georgia, 30041, United States
Novartis Investigative Site
Decatur, Georgia, 30033, United States
Novartis Investigative Site
Decatur, Georgia, 30035, United States
Novartis Investigative Site
Duluth, Georgia, 30096, United States
Novartis Investigative Site
Macon, Georgia, 31201, United States
Novartis Investigative Site
Roswell, Georgia, 30076, United States
Novartis Investigative Site
Savannah, Georgia, 31406, United States
Novartis Investigative Site
Thomasville, Georgia, 31792, United States
Novartis Investigative Site
Honolulu, Hawaii, 96814, United States
Novartis Investigative Site
Coeur d'Alene, Idaho, 83814, United States
Novartis Investigative Site
Chicago, Illinois, 60611, United States
Novartis Investigative Site
Jerseyville, Illinois, 62052, United States
Novartis Investigative Site
Lombard, Illinois, 60148, United States
Novartis Investigative Site
Melrose Park, Illinois, 60160, United States
Novartis Investigative Site
Peoria, Illinois, 61602, United States
Novartis Investigative Site
Evansville, Indiana, 47712, United States
Novartis Investigative Site
Evansville, Indiana, 47714, United States
Novartis Investigative Site
Ames, Iowa, 50010, United States
Novartis Investigative Site
Waterloo, Iowa, 50702, United States
Novartis Investigative Site
Kansas City, Kansas, 66160, United States
Novartis Investigative Site
Overland Park, Kansas, 66204, United States
Novartis Investigative Site
Topeka, Kansas, 66606, United States
Novartis Investigative Site
Wichita, Kansas, 67207, United States
Novartis Investigative Site
Wichita, Kansas, 67214, United States
Novartis Investigative Site
Lexington, Kentucky, 40509, United States
Novartis Investigative Site
Louisville, Kentucky, 40206, United States
Novartis Investigative Site
Madisonville, Kentucky, 42431, United States
Novartis Investigative Site
Owensboro, Kentucky, 42303, United States
Novartis Investigative Site
Baton Rouge, Louisiana, 70808, United States
Novartis Investigative Site
Baton Rouge, Louisiana, 70816, United States
Novartis Investigative Site
Covington, Louisiana, 70433, United States
Novartis Investigative Site
Houma, Louisiana, 70360, United States
Novartis Investigative Site
Lafayette, Louisiana, 70501, United States
Novartis Investigative Site
Lafayette, Louisiana, 70508, United States
Novartis Investigative Site
Mandeville, Louisiana, 70471, United States
Novartis Investigative Site
Metairie, Louisiana, 70001, United States
Novartis Investigative Site
Metairie, Louisiana, 70006, United States
Novartis Investigative Site
Minden, Louisiana, 71055, United States
Novartis Investigative Site
New Orleans, Louisiana, 70115, United States
Novartis Investigative Site
New Orleans, Louisiana, 70119, United States
Novartis Investigative Site
Opelousas, Louisiana, 70570, United States
Novartis Investigative Site
Shreveport, Louisiana, 71101, United States
Novartis Investigative Site
Shreveport, Louisiana, 71103, United States
Novartis Investigative Site
Slidell, Louisiana, 70458, United States
Novartis Investigative Site
Winnsboro, Louisiana, 71295, United States
Novartis Investigative Site
Zachary, Louisiana, 70791, United States
Novartis Investigative Site
Portland, Maine, 04102, United States
Novartis Investigative Site
Baltimore, Maryland, 21204, United States
Novartis Investigative Site
Beltsville, Maryland, 20705, United States
Novartis Investigative Site
Columbia, Maryland, 21044, United States
Novartis Investigative Site
Burlington, Massachusetts, 01803, United States
Novartis Investigative Site
Fall River, Massachusetts, 02720, United States
Novartis Investigative Site
Haverhill, Massachusetts, 01830, United States
Novartis Investigative Site
Ann Arbor, Michigan, 48106, United States
Novartis Investigative Site
Chelsea, Michigan, 48118, United States
Novartis Investigative Site
Detroit, Michigan, 48202, United States
Novartis Investigative Site
Grand Blanc, Michigan, 48439, United States
Novartis Investigative Site
Kalamazoo, Michigan, 49008, United States
Novartis Investigative Site
Midland, Michigan, 48640, United States
Novartis Investigative Site
Novi, Michigan, 48374, United States
Novartis Investigative Site
Petoskey, Michigan, 49770, United States
Novartis Investigative Site
Royal Oak, Michigan, 48073, United States
Novartis Investigative Site
Saginaw, Michigan, 48601, United States
Novartis Investigative Site
Wyoming, Michigan, 49519, United States
Novartis Investigative Site
Bloomington, Minnesota, 55420, United States
Novartis Investigative Site
Duluth, Minnesota, 55805, United States
Novartis Investigative Site
Edina, Minnesota, 55435, United States
Novartis Investigative Site
Fridley, Minnesota, 55432, United States
Novartis Investigative Site
Minneapolis, Minnesota, 55433, United States
Novartis Investigative Site
Robbinsdale, Minnesota, 55422, United States
Novartis Investigative Site
Saint Cloud, Minnesota, 56303, United States
Novartis Investigative Site
Saint Paul, Minnesota, 55102, United States
Novartis Investigative Site
Hattiesburg, Mississippi, 39401, United States
Novartis Investigative Site
Jackson, Mississippi, 39209, United States
Novartis Investigative Site
Picayune, Mississippi, 39466, United States
Novartis Investigative Site
Columbia, Missouri, 65212, United States
Novartis Investigative Site
Kansas City, Missouri, 64111, United States
Novartis Investigative Site
Springfield, Missouri, 65807, United States
Novartis Investigative Site
St Louis, Missouri, 63110, United States
Novartis Investigative Site
St Louis, Missouri, 63128, United States
Novartis Investigative Site
St Louis, Missouri, 63141, United States
Novartis Investigative Site
Grand Island, Nebraska, 68803, United States
Novartis Investigative Site
Lincoln, Nebraska, 68516, United States
Novartis Investigative Site
Omaha, Nebraska, 68114, United States
Novartis Investigative Site
Omaha, Nebraska, 68131, United States
Novartis Investigative Site
Omaha, Nebraska, 68134, United States
Novartis Investigative Site
Las Vegas, Nevada, 89118, United States
Novartis Investigative Site
Nashua, New Hampshire, 03060, United States
Novartis Investigative Site
Camden, New Jersey, 08103, United States
Novartis Investigative Site
Freehold, New Jersey, 07728, United States
Novartis Investigative Site
Lodi, New Jersey, 07644, United States
Novartis Investigative Site
New Brunswick, New Jersey, 08901, United States
Novartis Investigative Site
Ocean City, New Jersey, 07712, United States
Novartis Investigative Site
Pomona, New Jersey, 08240, United States
Novartis Investigative Site
Ridgewood, New Jersey, 07450, United States
Novartis Investigative Site
Westwood, New Jersey, 07675, United States
Novartis Investigative Site
Albuquerque, New Mexico, 87102, United States
Novartis Investigative Site
Binghamton, New York, 13901, United States
Novartis Investigative Site
Endwell, New York, 13760, United States
Novartis Investigative Site
Kew Gardens, New York, 11415, United States
Novartis Investigative Site
Mineola, New York, 11501, United States
Novartis Investigative Site
New York, New York, 10003, United States
Novartis Investigative Site
New York, New York, 10016, United States
Novartis Investigative Site
New York, New York, 10035, United States
Novartis Investigative Site
Rochester, New York, 14609, United States
Novartis Investigative Site
Rochester, New York, 14621, United States
Novartis Investigative Site
Asheboro, North Carolina, 27204, United States
Novartis Investigative Site
Charlotte, North Carolina, 28277, United States
Novartis Investigative Site
Greensboro, North Carolina, 27401, United States
Novartis Investigative Site
Greensboro, North Carolina, 27410, United States
Novartis Investigative Site
Greenville, North Carolina, 27834, United States
Novartis Investigative Site
Hickory, North Carolina, 28601, United States
Novartis Investigative Site
Mooresville, North Carolina, 28117, United States
Novartis Investigative Site
Pinehurst, North Carolina, 28374, United States
Novartis Investigative Site
Salisbury, North Carolina, 28144, United States
Novartis Investigative Site
Sanford, North Carolina, 27330, United States
Novartis Investigative Site
Statesville, North Carolina, 28625, United States
Novartis Investigative Site
Winston-Salem, North Carolina, 27103, United States
Novartis Investigative Site
Winston-Salem, North Carolina, 27106, United States
Novartis Investigative Site
Fargo, North Dakota, 58122, United States
Novartis Investigative Site
Grand Forks, North Dakota, 58201, United States
Novartis Investigative Site
Akron, Ohio, 44309, United States
Novartis Investigative Site
Cincinnati, Ohio, 45219, United States
Novartis Investigative Site
Cincinnati, Ohio, 45245, United States
Novartis Investigative Site
Cleveland, Ohio, 44109-1998, United States
Novartis Investigative Site
Columbus, Ohio, 43235, United States
Novartis Investigative Site
Dayton, Ohio, 45402, United States
Novartis Investigative Site
Marion, Ohio, 43302, United States
Novartis Investigative Site
Bartlesville, Oklahoma, 74006, United States
Novartis Investigative Site
Oklahoma City, Oklahoma, 73120, United States
Novartis Investigative Site
Tulsa, Oklahoma, 74133, United States
Novartis Investigative Site
Bend, Oregon, 97701, United States
Novartis Investigative Site
Portland, Oregon, 97225, United States
Novartis Investigative Site
Abington, Pennsylvania, 19001, United States
Novartis Investigative Site
Altoona, Pennsylvania, 16602, United States
Novartis Investigative Site
Beaver, Pennsylvania, 15009, United States
Novartis Investigative Site
Bridgeville, Pennsylvania, 15017, United States
Novartis Investigative Site
Camp Hill, Pennsylvania, 17011, United States
Novartis Investigative Site
Erie, Pennsylvania, 16507, United States
Novartis Investigative Site
Hershey, Pennsylvania, 17033, United States
Novartis Investigative Site
Pittsburgh, Pennsylvania, 15216, United States
Novartis Investigative Site
Pittsburgh, Pennsylvania, 15236, United States
Novartis Investigative Site
Pittsburgh, Pennsylvania, 15243, United States
Novartis Investigative Site
Pottstown, Pennsylvania, 19464, United States
Novartis Investigative Site
Uniontown, Pennsylvania, 15401, United States
Novartis Investigative Site
Cumberland, Rhode Island, 02864-1410, United States
Novartis Investigative Site
Providence, Rhode Island, 02904, United States
Novartis Investigative Site
Providence, Rhode Island, 02906, United States
Novartis Investigative Site
Anderson, South Carolina, 29621, United States
Novartis Investigative Site
Columbia, South Carolina, 29201, United States
Novartis Investigative Site
Fort Mill, South Carolina, 29707, United States
Novartis Investigative Site
Greenville, South Carolina, 29605, United States
Novartis Investigative Site
Greer, South Carolina, 29651, United States
Novartis Investigative Site
Moncks Corner, South Carolina, 29461, United States
Novartis Investigative Site
Mt. Pleasant, South Carolina, 29464, United States
Novartis Investigative Site
North Myrtle Beach, South Carolina, 29582, United States
Novartis Investigative Site
Orangeburg, South Carolina, 29115, United States
Novartis Investigative Site
Varnville, South Carolina, 29944, United States
Novartis Investigative Site
Rapid City, South Dakota, 57701, United States
Novartis Investigative Site
Sioux Falls, South Dakota, 57104, United States
Novartis Investigative Site
Germantown, Tennessee, 38138, United States
Novartis Investigative Site
Greenville, Tennessee, 37745, United States
Novartis Investigative Site
Jackson, Tennessee, 38305, United States
Novartis Investigative Site
Johnson City, Tennessee, 37604, United States
Novartis Investigative Site
Knoxville, Tennessee, 37917, United States
Novartis Investigative Site
Knoxville, Tennessee, 37920, United States
Novartis Investigative Site
Knoxville, Tennessee, 37934, United States
Novartis Investigative Site
Memphis, Tennessee, 38120, United States
Novartis Investigative Site
Allen, Texas, 75002-3688, United States
Novartis Investigative Site
Beaumont, Texas, 77701, United States
Novartis Investigative Site
Beaumont, Texas, 77702, United States
Novartis Investigative Site
Bedford, Texas, 76021, United States
Novartis Investigative Site
Brownsville, Texas, 78520, United States
Novartis Investigative Site
Dallas, Texas, 75204, United States
Novartis Investigative Site
Dallas, Texas, 75226, United States
Novartis Investigative Site
Dallas, Texas, 75231, United States
Novartis Investigative Site
Gonzales, Texas, 78629, United States
Novartis Investigative Site
Greenville, Texas, 75401, United States
Novartis Investigative Site
Houston, Texas, 77025, United States
Novartis Investigative Site
Houston, Texas, 77030, United States
Novartis Investigative Site
Houston, Texas, 77055, United States
Novartis Investigative Site
Houston, Texas, 77064, United States
Novartis Investigative Site
Houston, Texas, 77070, United States
Novartis Investigative Site
Houston, Texas, 77081, United States
Novartis Investigative Site
Irving, Texas, 75039, United States
Novartis Investigative Site
Lake Jackson, Texas, 77566, United States
Novartis Investigative Site
Leander, Texas, 78641, United States
Novartis Investigative Site
Livingston, Texas, 77351, United States
Novartis Investigative Site
Lufkin, Texas, 75904, United States
Novartis Investigative Site
Marshall, Texas, 75670, United States
Novartis Investigative Site
McAllen, Texas, 78501, United States
Novartis Investigative Site
McKinney, Texas, 75069, United States
Novartis Investigative Site
Odessa, Texas, 79761, United States
Novartis Investigative Site
San Antonio, Texas, 78212, United States
Novartis Investigative Site
San Antonio, Texas, 78229-3900, United States
Novartis Investigative Site
San Antonio, Texas, 78229-4801, United States
Novartis Investigative Site
San Antonio, Texas, 78229, United States
Novartis Investigative Site
San Antonio, Texas, 78234, United States
Novartis Investigative Site
San Antonio, Texas, 78238-7676, United States
Novartis Investigative Site
San Antonio, Texas, 78258, United States
Novartis Investigative Site
Sugar Land, Texas, 77479, United States
Novartis Investigative Site
Temple, Texas, 76508, United States
Novartis Investigative Site
Tomball, Texas, 77375, United States
Novartis Investigative Site
Waco, Texas, 76710, United States
Novartis Investigative Site
Webster, Texas, 77598, United States
Novartis Investigative Site
Bountiful, Utah, 84010, United States
Novartis Investigative Site
Layton, Utah, 84041, United States
Novartis Investigative Site
Salt Lake City, Utah, 84102, United States
Novartis Investigative Site
Salt Lake City, Utah, 84107, United States
Novartis Investigative Site
Salt Lake City, Utah, 84124, United States
Novartis Investigative Site
Burke, Virginia, 22015, United States
Novartis Investigative Site
Danville, Virginia, 24541, United States
Novartis Investigative Site
Hopewell, Virginia, 23860, United States
Novartis Investigative Site
Richmond, Virginia, 23249, United States
Novartis Investigative Site
Richmond, Virginia, 23298, United States
Novartis Investigative Site
Port Orchard, Washington, 98366, United States
Novartis Investigative Site
Renton, Washington, 98057, United States
Novartis Investigative Site
Seattle, Washington, 98104, United States
Novartis Investigative Site
Seattle, Washington, 98122, United States
Novartis Investigative Site
Tacoma, Washington, 98405, United States
Novartis Investigative Site
Madison, Wisconsin, 53713, United States
Novartis Investigative Site
Bahía Blanca, Buenos Aires, B8000AAT, Argentina
Novartis Investigative Site
CABA, Buenos Aires, 1428, Argentina
Novartis Investigative Site
CABA, Buenos Aires, C1056ABJ, Argentina
Novartis Investigative Site
CABA, Buenos Aires, C1221ADC, Argentina
Novartis Investigative Site
CABA, Buenos Aires, C1425AGC, Argentina
Novartis Investigative Site
CABA, Buenos Aires, C1425BWO, Argentina
Novartis Investigative Site
CABA, Buenos Aires, C1440AAD, Argentina
Novartis Investigative Site
Mar del Plata, Buenos Aires, 7600, Argentina
Novartis Investigative Site
Mar del Plata, Buenos Aires, B7600, Argentina
Novartis Investigative Site
Quilmes, Buenos Aires, B1878DVB, Argentina
Novartis Investigative Site
Quilmes, Buenos Aires, B1878GEG, Argentina
Novartis Investigative Site
Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Novartis Investigative Site
San Isidro, Buenos Aires, B1642DCD, Argentina
Novartis Investigative Site
San Nicolás de los Arroyos, Buenos Aires, B2900DMH, Argentina
Novartis Investigative Site
Zárate, Buenos Aires, 2800, Argentina
Novartis Investigative Site
CABA, Buenos Aires F.D., C1179AAB, Argentina
Novartis Investigative Site
CABA, Buenos Aires F.D., C1430CKE, Argentina
Novartis Investigative Site
San Salvador de Jujuy, Jujuy Province, Y4600ABF, Argentina
Novartis Investigative Site
Posadas, Misiones Province, N3300AHX, Argentina
Novartis Investigative Site
Cipolletti, Río Negro Province, 8324, Argentina
Novartis Investigative Site
San Miguel de Tucumán, San Miguel de Tucuman, T4000ICL, Argentina
Novartis Investigative Site
Rosario, Santa Fe Province, S2000CXP, Argentina
Novartis Investigative Site
Rosario, Santa Fe Province, S2000DSV, Argentina
Novartis Investigative Site
Rosario, Santa Fe Province, S2000, Argentina
Novartis Investigative Site
San Miguel de Tucumán, Tucumán Province, T4000EBR, Argentina
Novartis Investigative Site
San Miguel de Tucumán, Tucumán Province, T4000IFL, Argentina
Novartis Investigative Site
San Miguel de Tucumán, Tucumán Province, T4000IIH, Argentina
Novartis Investigative Site
CABA, C1119ACN, Argentina
Novartis Investigative Site
Corrientes, W3400CBI, Argentina
Novartis Investigative Site
Corrientes, W3400CLH, Argentina
Novartis Investigative Site
Corrientes, W3400, Argentina
Novartis Investigative Site
Corrientes, W3410AVV, Argentina
Novartis Investigative Site
Córdoba, 5000, Argentina
Novartis Investigative Site
Córdoba, X5000AAJ, Argentina
Novartis Investigative Site
Córdoba, X5000AAW, Argentina
Novartis Investigative Site
Córdoba, X5000AAX, Argentina
Novartis Investigative Site
Córdoba, X5000EPU, Argentina
Novartis Investigative Site
Córdoba, X5000JJS, Argentina
Novartis Investigative Site
Córdoba, X5003DCE, Argentina
Novartis Investigative Site
Córdoba, X5003DCP, Argentina
Novartis Investigative Site
Córdoba, X5006CBI, Argentina
Novartis Investigative Site
Córdoba, X5009BSN, Argentina
Novartis Investigative Site
Córdoba, X5022CPU, Argentina
Novartis Investigative Site
Córdoba, X5220XAO, Argentina
Novartis Investigative Site
Formosa, P3600, Argentina
Novartis Investigative Site
Formosa, P3634XAR, Argentina
Novartis Investigative Site
Salta, 4400, Argentina
Novartis Investigative Site
San Luis, D5702JRS, Argentina
Novartis Investigative Site
San Miguel de Tucumán, T4000HXU, Argentina
Novartis Investigative Site
Santa Fe, S3000EOZ, Argentina
Novartis Investigative Site
Santa Fe, S3000EPV, Argentina
Novartis Investigative Site
Santa Fe, S3000FWO, Argentina
Novartis Investigative Site
Santiago del Estero, G4200AQK, Argentina
Novartis Investigative Site
Garran, Australian Capital Territory, 2606, Australia
Novartis Investigative Site
Gosford, New South Wales, 2250, Australia
Novartis Investigative Site
Kogarah, New South Wales, 2217, Australia
Novartis Investigative Site
Liverpool, New South Wales, 2170, Australia
Novartis Investigative Site
Milton, Queensland, 4064, Australia
Novartis Investigative Site
Southport, Queensland, 4215, Australia
Novartis Investigative Site
Hobart, Tasmania, 7000, Australia
Novartis Investigative Site
Bundoora, Victoria, 3083, Australia
Novartis Investigative Site
Geelong, Victoria, 3220, Australia
Novartis Investigative Site
Bateman, Western Australia, 6150, Australia
Novartis Investigative Site
Joondalup, Western Australia, 6027, Australia
Novartis Investigative Site
Perth, Western Australia, 6000, Australia
Novartis Investigative Site
Saint Stefan, Austria, 8511, Austria
Novartis Investigative Site
Graz, A-8036, Austria
Novartis Investigative Site
Linz, 4010, Austria
Novartis Investigative Site
Linz, A-4010, Austria
Novartis Investigative Site
Salzburg, A-5020, Austria
Novartis Investigative Site
Vienna, 1030, Austria
Novartis Investigative Site
Vienna, A 1090, Austria
Novartis Investigative Site
Aalst, 9300, Belgium
Novartis Investigative Site
Bonheiden, 2820, Belgium
Novartis Investigative Site
Brasschaat, 2930, Belgium
Novartis Investigative Site
Brussels, 1000, Belgium
Novartis Investigative Site
De Pinte, 9840, Belgium
Novartis Investigative Site
Genk, 3600, Belgium
Novartis Investigative Site
Ghent, 9000, Belgium
Novartis Investigative Site
Hasselt, 3500, Belgium
Novartis Investigative Site
Huy, 4500, Belgium
Novartis Investigative Site
Leuven, 3000, Belgium
Novartis Investigative Site
Mechelen, 2800, Belgium
Novartis Investigative Site
Ottignies, 1340, Belgium
Novartis Investigative Site
Tienen, 3300, Belgium
Novartis Investigative Site
Fortaleza, Ceará, 60430 370, Brazil
Novartis Investigative Site
Salvador, Estado de Bahia, 40050-410, Brazil
Novartis Investigative Site
Salvador, Estado de Bahia, 40140-110, Brazil
Novartis Investigative Site
Brasília, Federal District, 70390-903, Brazil
Novartis Investigative Site
Brasília, Federal District, 70658-700, Brazil
Novartis Investigative Site
Goiânia, Goiás, 74223-130, Brazil
Novartis Investigative Site
Goiânia, Goiás, 74605-020, Brazil
Novartis Investigative Site
Campo Grande, Mato Grosso do Sul, 79080-190, Brazil
Novartis Investigative Site
Belo Horizonte, Minas Gerais, 30130-060, Brazil
Novartis Investigative Site
Belo Horizonte, Minas Gerais, 30150-221, Brazil
Novartis Investigative Site
Uberlândia, Minas Gerais, 38405-320, Brazil
Novartis Investigative Site
Uberlândia, Minas Gerais, 38411 186, Brazil
Novartis Investigative Site
Curitiba, Paraná, 80730-150, Brazil
Novartis Investigative Site
Belém, Pará, 66087-660, Brazil
Novartis Investigative Site
Recife, Pernambuco, 52051-380, Brazil
Novartis Investigative Site
Passo Fundo, Rio Grande do Sul, 99010-080, Brazil
Novartis Investigative Site
Pelotas, Rio Grande do Sul, 96015-290, Brazil
Novartis Investigative Site
Porto Alegre, Rio Grande do Sul, 90560-030, Brazil
Novartis Investigative Site
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Novartis Investigative Site
Porto Alegre, Rio Grande do Sul, 90620 001, Brazil
Novartis Investigative Site
Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
Novartis Investigative Site
Porto Alegre, Rio Grande do Sul, 91350 200, Brazil
Novartis Investigative Site
Blumenau, Santa Catarina, 89020 430, Brazil
Novartis Investigative Site
Campinas, São Paulo, 13010-001, Brazil
Novartis Investigative Site
Campinas, São Paulo, 13020-431, Brazil
Novartis Investigative Site
Campinas, São Paulo, 13060 080, Brazil
Novartis Investigative Site
Santo André, São Paulo, 09190-615, Brazil
Novartis Investigative Site
São José do Rio Preto, São Paulo, 15090 000, Brazil
Novartis Investigative Site
São Paulo, São Paulo, 01323 000, Brazil
Novartis Investigative Site
São Paulo, São Paulo, 04023-900, Brazil
Novartis Investigative Site
São Paulo, São Paulo, 05403-000, Brazil
Novartis Investigative Site
São Paulo, São Paulo, 05508-000, Brazil
Novartis Investigative Site
Tatuí, São Paulo, 18270-170, Brazil
Novartis Investigative Site
Votuporanga, São Paulo, 15500 003, Brazil
Novartis Investigative Site
Pazardzhik, 4400, Bulgaria
Novartis Investigative Site
Pleven, 5800, Bulgaria
Novartis Investigative Site
Plovdiv, 4000, Bulgaria
Novartis Investigative Site
Sofia, 1000, Bulgaria
Novartis Investigative Site
Sofia, 1202, Bulgaria
Novartis Investigative Site
Sofia, 1233, Bulgaria
Novartis Investigative Site
Sofia, 1309, Bulgaria
Novartis Investigative Site
Sofia, 1431, Bulgaria
Novartis Investigative Site
Sofia, 1527, Bulgaria
Novartis Investigative Site
Sofia, 1606, Bulgaria
Novartis Investigative Site
New Westminster, British Columbia, V3L 3W4, Canada
Novartis Investigative Site
Surrey, British Columbia, V3V 0C6, Canada
Novartis Investigative Site
Victoria, British Columbia, V8R4R2, Canada
Novartis Investigative Site
Winnipeg, Manitoba, R2V 4W3, Canada
Novartis Investigative Site
Mount Pearl, Newfoundland and Labrador, A1N 1W7, Canada
Novartis Investigative Site
Halifax, Nova Scotia, B3H 3A7, Canada
Novartis Investigative Site
Cambridge, Ontario, N1R 6V6, Canada
Novartis Investigative Site
Etobicoke, Ontario, M9V 4B4, Canada
Novartis Investigative Site
Hamilton, Ontario, L8L 2X2, Canada
Novartis Investigative Site
Kitchener, Ontario, N2M 5N4, Canada
Novartis Investigative Site
Mississauga, Ontario, L5K 2L3, Canada
Novartis Investigative Site
Newmarket, Ontario, L3Y 2P7, Canada
Novartis Investigative Site
Newmarket, Ontario, L3Y 8C3, Canada
Novartis Investigative Site
Ottawa, Ontario, K1Y 4W7, Canada
Novartis Investigative Site
Peterborough, Ontario, K9J 0B2, Canada
Novartis Investigative Site
Scarborough Village, Ontario, M1P 2V5, Canada
Novartis Investigative Site
Toronto, Ontario, M5B 1N9, Canada
Novartis Investigative Site
Toronto, Ontario, M9W 4L6, Canada
Novartis Investigative Site
Drummondville, Quebec, J2B 7T1, Canada
Novartis Investigative Site
Gatineau, Quebec, J8Y 6S8, Canada
Novartis Investigative Site
Granby, Quebec, J2G 1T7, Canada
Novartis Investigative Site
Joliette, Quebec, J6E 6J2, Canada
Novartis Investigative Site
Lachine, Quebec, H8S 2E4, Canada
Novartis Investigative Site
Laval, Quebec, H7M 3L9, Canada
Novartis Investigative Site
Lévis, Quebec, G6V 4Z5, Canada
Novartis Investigative Site
Longueuil, Quebec, J4M 2X1, Canada
Novartis Investigative Site
Montreal, Quebec, H3G 1A4, Canada
Novartis Investigative Site
Montreal, Quebec, H4J 1C5, Canada
Novartis Investigative Site
Québec, Quebec, G1G 3Y8, Canada
Novartis Investigative Site
Québec, Quebec, G1V 4G2, Canada
Novartis Investigative Site
Québec, Quebec, G3K 2P8, Canada
Novartis Investigative Site
Saint-Jean-sur-Richelieu, Quebec, J3A 1J2, Canada
Novartis Investigative Site
Sainte-Foy, Quebec, G1V 4G5, Canada
Novartis Investigative Site
Sherbrooke, Quebec, J1G-2E8, Canada
Novartis Investigative Site
Ste-Foy, Quebec, G1W 4R4, Canada
Novartis Investigative Site
Terrebonne, Quebec, J6V 2H2, Canada
Novartis Investigative Site
Thetford-Mines, Quebec, G6G 2V4, Canada
Novartis Investigative Site
Saskatoon, Saskatchewan, S7H 5M3, Canada
Novartis Investigative Site
Beijing, Beijing Municipality, 100730, China
Novartis Investigative Site
Chongqing, Chongqing Municipality, 400010, China
Novartis Investigative Site
Fuzhou, Fujian, China
Novartis Investigative Site
Guangzhou, Guangdong, 510000, China
Novartis Investigative Site
Guangzhou, Guangdong, 51000, China
Novartis Investigative Site
Nanning, Guangxi, 530021, China
Novartis Investigative Site
Shijiazhuang, Hebei, 050000, China
Novartis Investigative Site
Harbin, Heilongjiang, 150000, China
Novartis Investigative Site
Wuhan, Hubei, 430022, China
Novartis Investigative Site
Wuhan, Hubei, 430060, China
Novartis Investigative Site
Changsha, Hunan, 410003, China
Novartis Investigative Site
Baotou, Inner Mongolia, 014040, China
Novartis Investigative Site
Nanjing, Jiangsu, 210009, China
Novartis Investigative Site
Suzhou, Jiangsu, 215006, China
Novartis Investigative Site
Changchun, Jilin, 130033, China
Novartis Investigative Site
Shenyang, Liaoning, 110003, China
Novartis Investigative Site
Shenyang, Liaoning, 110016, China
Novartis Investigative Site
Shanghai, Shanghai Municipality, 200032, China
Novartis Investigative Site
Shanghai, Shanghai Municipality, 200120, China
Novartis Investigative Site
Shanghai, Shanghai Municipality, China
Novartis Investigative Site
Xian, Shanxi, 710004, China
Novartis Investigative Site
Xian, Shanxi, 710061, China
Novartis Investigative Site
Tianjin, Tianjin Municipality, 300121, China
Novartis Investigative Site
Hangzhou, Zhejiang, 310013, China
Novartis Investigative Site
Hangzhou, Zhejiang, 310016, China
Novartis Investigative Site
Beijing, 100010, China
Novartis Investigative Site
Beijing, 100028, China
Novartis Investigative Site
Beijing, 100029, China
Novartis Investigative Site
Beijing, 100034, China
Novartis Investigative Site
Beijing, 100038, China
Novartis Investigative Site
Beijing, 100176, China
Novartis Investigative Site
Shanghai, 200080, China
Novartis Investigative Site
Tianjin, 300142, China
Novartis Investigative Site
Tianjin, 30045, China
Novartis Investigative Site
Baranquilla, Atlántico, Colombia
Novartis Investigative Site
Barranquilla, Atlántico, Colombia
Novartis Investigative Site
Manizales, Caldas Department, 1700, Colombia
Novartis Investigative Site
Cartegena, Colombia, Colombia
Novartis Investigative Site
Cartagena, Departamento de Bolívar, Colombia
Novartis Investigative Site
Bucaramanga, Santander Department, Colombia
Novartis Investigative Site
Floridablanca, Santander Department, 57-7, Colombia
Novartis Investigative Site
Armenia, Colombia
Novartis Investigative Site
Baranquilla, Colombia
Novartis Investigative Site
Barranquilla, 080020, Colombia
Novartis Investigative Site
Barranquilla, Colombia
Novartis Investigative Site
Bogotá, Colombia
Novartis Investigative Site
Cali, Colombia
Novartis Investigative Site
Florida Blanca, Colombia
Novartis Investigative Site
Varaždin, HRV, 42000, Croatia
Novartis Investigative Site
Čakovec, 40000, Croatia
Novartis Investigative Site
Koprivnica, 48000, Croatia
Novartis Investigative Site
Krapinske Toplice, 49 217, Croatia
Novartis Investigative Site
Krapinske Toplice, 49217, Croatia
Novartis Investigative Site
Opatija, 51410, Croatia
Novartis Investigative Site
Rijeka, 51000, Croatia
Novartis Investigative Site
Virovitica, 33000, Croatia
Novartis Investigative Site
Zagreb, 10000, Croatia
Novartis Investigative Site
Brandýs nad Labem, Czech Republic, 250 01, Czechia
Novartis Investigative Site
Jablonec nad Nisou, Czech Republic, 466 01, Czechia
Novartis Investigative Site
Kladno, Czech Republic, 272 80, Czechia
Novartis Investigative Site
Liberec, Czech Republic, 460 05, Czechia
Novartis Investigative Site
Louny, Czech Republic, Czechia
Novartis Investigative Site
Ostrava, Czech Republic, 70200, Czechia
Novartis Investigative Site
Pilsen, Czech Republic, 301 00, Czechia
Novartis Investigative Site
Prague, Czech Republic, 148 00, Czechia
Novartis Investigative Site
Prague, Czech Republic, Czechia
Novartis Investigative Site
Rožnov pod Radhoštěm, Czech Republic, 756 61, Czechia
Novartis Investigative Site
Semily, Czech Republic, 513 31, Czechia
Novartis Investigative Site
Svitavy, Czech Republic, 568 25, Czechia
Novartis Investigative Site
Třebíč, Czech Republic, 674 01, Czechia
Novartis Investigative Site
Ústí nad Labem, Czech Republic, 400 01, Czechia
Novartis Investigative Site
Ústí nad Orlicí, Czech Republic, 562 18, Czechia
Novartis Investigative Site
Vyškov, Czech Republic, 68001, Czechia
Novartis Investigative Site
Znojmo, Czech Republic, 66902, Czechia
Novartis Investigative Site
Most, CZE, 434 01, Czechia
Novartis Investigative Site
Prague, CZE, 128 08, Czechia
Novartis Investigative Site
Trutnov, CZE, 46063, Czechia
Novartis Investigative Site
Benešov, 25601, Czechia
Novartis Investigative Site
Brno-Bohunice, 625 00, Czechia
Novartis Investigative Site
Broumov, 550 01, Czechia
Novartis Investigative Site
Kolín, 280 20, Czechia
Novartis Investigative Site
Mariánské Lázně, 353 01, Czechia
Novartis Investigative Site
Pardubice, 530 02, Czechia
Novartis Investigative Site
Prague, 12808, Czechia
Novartis Investigative Site
Prague 4 - Krc, 14059, Czechia
Novartis Investigative Site
Slaný, 274 01, Czechia
Novartis Investigative Site
Teplice, 415 29, Czechia
Novartis Investigative Site
Uherské Hradiště, 68601, Czechia
Novartis Investigative Site
Pärnu, 80010, Estonia
Novartis Investigative Site
Saku, 75501, Estonia
Novartis Investigative Site
Tallinn, 10138, Estonia
Novartis Investigative Site
Tallinn, 10611, Estonia
Novartis Investigative Site
Tallinn, 13419, Estonia
Novartis Investigative Site
Tallinn, 13619, Estonia
Novartis Investigative Site
Tartu, 50410, Estonia
Novartis Investigative Site
Viljandi County, 71024, Estonia
Novartis Investigative Site
Võru, 65608, Estonia
Novartis Investigative Site
Muehlheim An Der Ruhr, North Rhine-Westphalia, 45468, Germany
Novartis Investigative Site
Bad Krozingen, 79189, Germany
Novartis Investigative Site
Balve, 58802, Germany
Novartis Investigative Site
Berlin, 10117, Germany
Novartis Investigative Site
Berlin, 10367, Germany
Novartis Investigative Site
Berlin, 10629, Germany
Novartis Investigative Site
Berlin, 10789, Germany
Novartis Investigative Site
Berlin, 12627, Germany
Novartis Investigative Site
Berlin, 13055, Germany
Novartis Investigative Site
Berlin, 13353, Germany
Novartis Investigative Site
Bochum, 44787, Germany
Novartis Investigative Site
Borna, 04552, Germany
Novartis Investigative Site
Chemnitz, 09122, Germany
Novartis Investigative Site
Chemnitz, 09130, Germany
Novartis Investigative Site
Cologne, 51065, Germany
Novartis Investigative Site
Dillingen, 66763, Germany
Novartis Investigative Site
Dinslaken, 46535, Germany
Novartis Investigative Site
Dortmund, 44137, Germany
Novartis Investigative Site
Dresden, 01067, Germany
Novartis Investigative Site
Dresden, 01069, Germany
Novartis Investigative Site
Dresden, 01277, Germany
Novartis Investigative Site
Dresden, 01307, Germany
Novartis Investigative Site
Dresden, 01309, Germany
Novartis Investigative Site
Duisburg, 47137, Germany
Novartis Investigative Site
Düsseldorf, 40597, Germany
Novartis Investigative Site
Ebersbach, 02730, Germany
Novartis Investigative Site
Elsterwerda, 04910, Germany
Novartis Investigative Site
Erlangen, 91054, Germany
Novartis Investigative Site
Essen, 45136, Germany
Novartis Investigative Site
Essen, 45276, Germany
Novartis Investigative Site
Essen, 45355, Germany
Novartis Investigative Site
Falkensee, 14612, Germany
Novartis Investigative Site
Frankfurt, 60488, Germany
Novartis Investigative Site
Frankfurt, 60594, Germany
Novartis Investigative Site
Frankfurt am Main, 60313, Germany
Novartis Investigative Site
Freiburg im Breisgau, 79106, Germany
Novartis Investigative Site
Fulda, 36037, Germany
Novartis Investigative Site
Giengen an der Brenz, 89537, Germany
Novartis Investigative Site
Görlitz, 02826, Germany
Novartis Investigative Site
Haag, 83527, Germany
Novartis Investigative Site
Halle, 06120, Germany
Novartis Investigative Site
Hamburg, 20246, Germany
Novartis Investigative Site
Hamburg, 22041, Germany
Novartis Investigative Site
Hamburg, 22177, Germany
Novartis Investigative Site
Hamburg, 22393, Germany
Novartis Investigative Site
Hamburg, 22765, Germany
Novartis Investigative Site
Heidelberg, 69120, Germany
Novartis Investigative Site
Heilbronn, 74078, Germany
Novartis Investigative Site
Huy / OT Anderbeck, 38836, Germany
Novartis Investigative Site
Jerichow, 39319, Germany
Novartis Investigative Site
Kallstadt, 67169, Germany
Novartis Investigative Site
Kamp-Lintfort, 47475, Germany
Novartis Investigative Site
Kassel, 34127, Germany
Novartis Investigative Site
Kiel, 24119, Germany
Novartis Investigative Site
Koblenz, 56068, Germany
Novartis Investigative Site
Künzing, 94550, Germany
Novartis Investigative Site
Leipzig, 04103, Germany
Novartis Investigative Site
Leipzig, 04107, Germany
Novartis Investigative Site
Ludwigshafen, 67063, Germany
Novartis Investigative Site
Lüneburg, 21339, Germany
Novartis Investigative Site
Magdeburg, 39112, Germany
Novartis Investigative Site
Mainz, 55116, Germany
Novartis Investigative Site
Mainz, 55131, Germany
Novartis Investigative Site
Mayen, 56727, Germany
Novartis Investigative Site
Meissen, 01662, Germany
Novartis Investigative Site
Meißen, 01662, Germany
Novartis Investigative Site
Muehldorf Am Inn, 84453, Germany
Novartis Investigative Site
Mühlhausen, 99974, Germany
Novartis Investigative Site
Neuhofen, 67141, Germany
Novartis Investigative Site
Neunkirchen, 66539, Germany
Novartis Investigative Site
Northeim, 37154, Germany
Novartis Investigative Site
Nuremberg, 90402, Germany
Novartis Investigative Site
Oelde, 59302, Germany
Novartis Investigative Site
Oschatz, 04758, Germany
Novartis Investigative Site
Paderborn, 33098, Germany
Novartis Investigative Site
Potsdam, 14469, Germany
Novartis Investigative Site
Rednitzhembach, 91126, Germany
Novartis Investigative Site
Reinfeld, 23858, Germany
Novartis Investigative Site
Rostock, 06120, Germany
Novartis Investigative Site
Rüdersdorf, 15562, Germany
Novartis Investigative Site
Siegen, 57072, Germany
Novartis Investigative Site
Ulm, 89081, Germany
Novartis Investigative Site
Wolmirstedt, 39326, Germany
Novartis Investigative Site
Crete Heraklion, Greece, 714 09, Greece
Novartis Investigative Site
Heraklion Crete, Greece, 711 10, Greece
Novartis Investigative Site
Athens, GR, 14233, Greece
Novartis Investigative Site
Magoula, GR, 190 18, Greece
Novartis Investigative Site
Thessaloniki, GR, 564 03, Greece
Novartis Investigative Site
Thessaloniki, GR, 570 10, Greece
Novartis Investigative Site
Voula, GR, 166 73, Greece
Novartis Investigative Site
Athens, 106 76, Greece
Novartis Investigative Site
Athens, 115 27, Greece
Novartis Investigative Site
Athens, 12462, Greece
Novartis Investigative Site
Chalcis, GR 341 00, Greece
Novartis Investigative Site
Pátrai, 265 00, Greece
Novartis Investigative Site
Guatemala City, 01001, Guatemala
Novartis Investigative Site
Guatemala City, 01010, Guatemala
Novartis Investigative Site
Guatemala City, 01011, Guatemala
Novartis Investigative Site
Guatemala City, 01015, Guatemala
Novartis Investigative Site
Zalaegerszeg, Zala County, 8900, Hungary
Novartis Investigative Site
Budapest, 1042, Hungary
Novartis Investigative Site
Budapest, 1083, Hungary
Novartis Investigative Site
Budapest, 1122, Hungary
Novartis Investigative Site
Budapest, 1125, Hungary
Novartis Investigative Site
Budapest, 1134, Hungary
Novartis Investigative Site
Budapest, 1145, Hungary
Novartis Investigative Site
Budapest, H-1115, Hungary
Novartis Investigative Site
Csongrád, 6640, Hungary
Novartis Investigative Site
Debrecen, 4032, Hungary
Novartis Investigative Site
Gyula, 5700, Hungary
Novartis Investigative Site
Kistarcsa, 2143, Hungary
Novartis Investigative Site
Komárom, 2921, Hungary
Novartis Investigative Site
Miskolc, 3530, Hungary
Novartis Investigative Site
Mosonmagyaróvár, 9200, Hungary
Novartis Investigative Site
Nyiregyháza, 4400, Hungary
Novartis Investigative Site
Pécs, 7623, Hungary
Novartis Investigative Site
Szeged, H 6725, Hungary
Novartis Investigative Site
Szentes, 6600, Hungary
Novartis Investigative Site
Székesfehérvár, H-8000, Hungary
Novartis Investigative Site
Kopavogur, 201, Iceland
Novartis Investigative Site
Reykjavik, IS-101, Iceland
Novartis Investigative Site
Reykjavik, IS-109, Iceland
Novartis Investigative Site
Hyderabad, Andhra Pradesh, 500001, India
Novartis Investigative Site
Hyderabad, Andhra Pradesh, India
Novartis Investigative Site
Nampally, Andhra Pradesh, 500 001, India
Novartis Investigative Site
Nellore, Andhra Pradesh, 524 003, India
Novartis Investigative Site
Tirupati, Andhra Pradesh, 517 5-7, India
Novartis Investigative Site
Vijayawada, Andhra Pradesh, 520 008, India
Novartis Investigative Site
Vijayawada, Andhra Pradesh, 520010, India
Novartis Investigative Site
Visakhapatnam, Andhra Pradesh, 530 013, India
Novartis Investigative Site
Guntur, Andhrapradesh, 522001, India
Novartis Investigative Site
Ahmedabad, Gujarat, 380 051, India
Novartis Investigative Site
Ahmedabad, Gujarat, 380006, India
Novartis Investigative Site
Ahmedabad, Gujarat, 380054, India
Novartis Investigative Site
Ahmedabad, Gujarat, 382428, India
Novartis Investigative Site
Surat, Gujarat, 395 002, India
Novartis Investigative Site
Surat, Gujarat, 395001, India
Novartis Investigative Site
Vadodara, Gujarat, 390015, India
Novartis Investigative Site
Bangalore, Karnataka, 560 055, India
Novartis Investigative Site
Bengaluru, Karnataka, 560034, India
Novartis Investigative Site
Manipal, Karnataka, 576104, India
Novartis Investigative Site
Kochi, Kerala, 682 018, India
Novartis Investigative Site
Nagpur, Maharashtra, 400012, India
Novartis Investigative Site
Nagpur, Maharashtra, 440 010, India
Novartis Investigative Site
Nagpur, Maharashtra, 44000033, India
Novartis Investigative Site
Nagpur, Maharashtra, 440012, India
Novartis Investigative Site
Nashik, Maharashtra, 422 005, India
Novartis Investigative Site
Pune, Maharashtra, 411004, India
Novartis Investigative Site
Pune, Maharashtra, 411005, India
Novartis Investigative Site
New Delhi, National Capital Territory of Delhi, 110060, India
Novartis Investigative Site
Ludhiana, Punjab, 141002, India
Novartis Investigative Site
Ludhiana, Punjab, 141012, India
Novartis Investigative Site
Ludhiana, Punjab, 141421, India
Novartis Investigative Site
Mohali, Punjab, 160 062, India
Novartis Investigative Site
Bikaner, Rajasthan, 334003, India
Novartis Investigative Site
Jaipur, Rajasthan, 302016, India
Novartis Investigative Site
Jaipur, Rajasthan, 302024, India
Novartis Investigative Site
Rajasthan, Rajasthan, 324005, India
Novartis Investigative Site
Chennai, Tamil Nadu, 600081, India
Novartis Investigative Site
Coimbatore, Tamil Nadu, 641 018, India
Novartis Investigative Site
Coimbatore, Tamil Nadu, 641037, India
Novartis Investigative Site
Madurai, Tamil Nadu, 625107, India
Novartis Investigative Site
Hyderabad, Telangana, 500 063, India
Novartis Investigative Site
Secunderabad, Telangana, 500003, India
Novartis Investigative Site
Ghaziabad, Uttar Pradesh, India
Novartis Investigative Site
Lucknow, Uttar Pradesh, 226005, India
Novartis Investigative Site
Varanasi, Uttar Pradesh, 224105, India
Novartis Investigative Site
Ahmedabad, 380025, India
Novartis Investigative Site
Ancona, AN, 60128, Italy
Novartis Investigative Site
Fermo, AP, 63023, Italy
Novartis Investigative Site
Cortona, AR, 52044, Italy
Novartis Investigative Site
Bergamo, BG, 24127, Italy
Novartis Investigative Site
Treviglio, BG, 24047, Italy
Novartis Investigative Site
Brescia, BS, 25123, Italy
Novartis Investigative Site
Montichiari, BS, 25018, Italy
Novartis Investigative Site
Monserrato, CA, 09042, Italy
Novartis Investigative Site
Santa Maria Capua Vetere, CE, 81055, Italy
Novartis Investigative Site
Chieti, CH, 66100, Italy
Novartis Investigative Site
Catanzaro, CZ, 88100, Italy
Novartis Investigative Site
Cona, FE, 44100, Italy
Novartis Investigative Site
Foggia, FG, 71100, Italy
Novartis Investigative Site
Florence, FI, 50134, Italy
Novartis Investigative Site
Pozzilli, IS, 86077, Italy
Novartis Investigative Site
Milan, MI, 20100, Italy
Novartis Investigative Site
Milan, MI, 20132, Italy
Novartis Investigative Site
Milan, MI, 20145, Italy
Novartis Investigative Site
Rozzano, MI, 20089, Italy
Novartis Investigative Site
Massa, MS, 54100, Italy
Novartis Investigative Site
Palermo, PA, 90129, Italy
Novartis Investigative Site
Piacenza, PC, 29100, Italy
Novartis Investigative Site
Pisa, PI, 56126, Italy
Novartis Investigative Site
Parma, PR, 43100, Italy
Novartis Investigative Site
Casorate Primo, PV, 27022, Italy
Novartis Investigative Site
Pavia, PV, 27100, Italy
Novartis Investigative Site
Roma, RM, 00161, Italy
Novartis Investigative Site
Roma, RM, 00168, Italy
Novartis Investigative Site
Roma, RM, 00189, Italy
Novartis Investigative Site
Sassari, SS, 07100, Italy
Novartis Investigative Site
Palmanova, UD, 33057, Italy
Novartis Investigative Site
San Daniele del Friuli, UD, 33038, Italy
Novartis Investigative Site
Verona, VR, 37134, Italy
Novartis Investigative Site
Soriano Calabro, VV, 89831, Italy
Novartis Investigative Site
Napoli, 80131, Italy
Novartis Investigative Site
Novara, 28100, Italy
Novartis Investigative Site
Veruno, 28010, Italy
Novartis Investigative Site
Ichinomiya, Aichi-ken, 491-8551, Japan
Novartis Investigative Site
Nagoya, Aichi-ken, 453-8511, Japan
Novartis Investigative Site
Seto, Aichi-ken, 489-8642, Japan
Novartis Investigative Site
Funabashi, Chiba, 273-8588, Japan
Novartis Investigative Site
Matsudo, Chiba, 270-2251, Japan
Novartis Investigative Site
Matsudo, Chiba, 271 0077, Japan
Novartis Investigative Site
Kasuga, Fukuoka, 816-0864, Japan
Novartis Investigative Site
Kurume, Fukuoka, 830-8577, Japan
Novartis Investigative Site
Onga-gun, Fukuoka, 807-0051, Japan
Novartis Investigative Site
Yukuhashi, Fukuoka, 824-0026, Japan
Novartis Investigative Site
Ōgaki, Gifu, 503-8502, Japan
Novartis Investigative Site
Fujioka, Gunma, 375-8503, Japan
Novartis Investigative Site
Takasaki, Gunma, 370-0036, Japan
Novartis Investigative Site
Hatsukaichi, Hiroshima, 738 8503, Japan
Novartis Investigative Site
Amagasaki, Hyōgo, 660 8550, Japan
Novartis Investigative Site
Amagasaki, Hyōgo, 661-0976, Japan
Novartis Investigative Site
Nishinomiya, Hyōgo, 663 8501, Japan
Novartis Investigative Site
Takarazuka, Hyōgo, 665-0022, Japan
Novartis Investigative Site
Higashiibaraki-gun, Ibaraki, 311-3193, Japan
Novartis Investigative Site
Hitachi, Ibaraki, 317-0077, Japan
Novartis Investigative Site
Sakaidechō, Kagawa-ken, 762-0007, Japan
Novartis Investigative Site
Takamatsu, Kagawa-ken, 760 8557, Japan
Novartis Investigative Site
Yokohama, Kanagawa, 234-0054, Japan
Novartis Investigative Site
Kumamoto, Kumamoto, 860-8556, Japan
Novartis Investigative Site
Kyoto, Kyoto, 607-8062, Japan
Novartis Investigative Site
Sendai, Miyagi, 980 8574, Japan
Novartis Investigative Site
Sendai, Miyagi, 983 8520, Japan
Novartis Investigative Site
Nagano, Nagano, 380 0814, Japan
Novartis Investigative Site
Hirakata, Osaka, 573-0153, Japan
Novartis Investigative Site
Osaka, Osaka, 543-0035, Japan
Novartis Investigative Site
Osaka, Osaka, 543-8555, Japan
Novartis Investigative Site
Osaka, Osaka, 558-8558, Japan
Novartis Investigative Site
Takatsuki, Osaka, 569-0852, Japan
Novartis Investigative Site
Sayama, Saitama, 350-1305, Japan
Novartis Investigative Site
Tokorozawa, Saitama, 359-1142, Japan
Novartis Investigative Site
Kusatsu, Shiga, 525-0014, Japan
Novartis Investigative Site
Komatsushimachō, Tokushima, 773-8502, Japan
Novartis Investigative Site
Bunkyo-ku, Tokyo, 113-8603, Japan
Novartis Investigative Site
Chiyoda-ku, Tokyo, 101-8309, Japan
Novartis Investigative Site
Chiyoda-ku, Tokyo, 101-8643, Japan
Novartis Investigative Site
Fuchū, Tokyo, 183-0003, Japan
Novartis Investigative Site
Itabashi-ku, Tokyo, 173-8610, Japan
Novartis Investigative Site
Liepāja, LV, LV-3414, Latvia
Novartis Investigative Site
Riga, LV, LV-1005, Latvia
Novartis Investigative Site
Ventspils, LV, LV-3601, Latvia
Novartis Investigative Site
Daugavpils, LV-5417, Latvia
Novartis Investigative Site
Riga, 1012, Latvia
Novartis Investigative Site
Valmiera, 4201, Latvia
Novartis Investigative Site
Kaunas, LTU, LT 50161, Lithuania
Novartis Investigative Site
Klaipėda, LTU, LT-92288, Lithuania
Novartis Investigative Site
Alytus, LT-62386, Lithuania
Novartis Investigative Site
Kaunas, LT-44320, Lithuania
Novartis Investigative Site
Kaunas, LT-49387, Lithuania
Novartis Investigative Site
Kaunas, LT-49449, Lithuania
Novartis Investigative Site
Kėdainiai, LT-57164, Lithuania
Novartis Investigative Site
Panevezys, LT-37460, Lithuania
Novartis Investigative Site
Šiauliai, LT-76231, Lithuania
Novartis Investigative Site
Vilnius, LT-08661, Lithuania
Novartis Investigative Site
Guadalajara, Jalisco, 44210, Mexico
Novartis Investigative Site
Guadalajara, Jalisco, 44280, Mexico
Novartis Investigative Site
San Luis Potosí City, San Luis Potosí, 78240, Mexico
Novartis Investigative Site
Culiacán, Sinaloa, 80230, Mexico
Novartis Investigative Site
Aguascalientes, 20230, Mexico
Novartis Investigative Site
Querétaro, 76000, Mexico
Novartis Investigative Site
San Luis Potosí City, 78200, Mexico
Novartis Investigative Site
Maastricht, AZ, 5800, Netherlands
Novartis Investigative Site
Apeldoorn, DZ, 7334, Netherlands
Novartis Investigative Site
Sneek, The Netherlands, 8601 ZR, Netherlands
Novartis Investigative Site
Alkmaar, 1815 JD, Netherlands
Novartis Investigative Site
Amersfoort, 3813 TZ, Netherlands
Novartis Investigative Site
Amstelveen, 1186 AM, Netherlands
Novartis Investigative Site
Amsterdam, 1090 HM, Netherlands
Novartis Investigative Site
Amsterdam, 1105 AZ, Netherlands
Novartis Investigative Site
Breda, 4811SW, Netherlands
Novartis Investigative Site
Deventer, 7416 SE, Netherlands
Novartis Investigative Site
Doetinchem, 7009 BL, Netherlands
Novartis Investigative Site
Ede, 6716 RP, Netherlands
Novartis Investigative Site
Gouda, 2803 HH, Netherlands
Novartis Investigative Site
Groningen, NL-9711 SG, Netherlands
Novartis Investigative Site
Haarlem, 2035 RC, Netherlands
Novartis Investigative Site
Heerlen, 6419 PC, Netherlands
Novartis Investigative Site
Hoorn, 1624 NP, Netherlands
Novartis Investigative Site
Leeuwarden, 8934 AD, Netherlands
Novartis Investigative Site
Meppel, 7943 KA, Netherlands
Novartis Investigative Site
Nijmegen, Netherlands
Novartis Investigative Site
Rotterdam, 3001 HG, Netherlands
Novartis Investigative Site
Rotterdam, 3083 AN, Netherlands
Novartis Investigative Site
Tiel, 4002 WP, Netherlands
Novartis Investigative Site
Utrecht, 3584 CX, Netherlands
Novartis Investigative Site
Venlo, 5912 BL, Netherlands
Novartis Investigative Site
Ålesund, NO-6026, Norway
Novartis Investigative Site
Elverum, 2408, Norway
Novartis Investigative Site
Hamar, 2317, Norway
Novartis Investigative Site
Harstad, 9481, Norway
Novartis Investigative Site
Hønefoss, 3501, Norway
Novartis Investigative Site
Lillehammer, 2629, Norway
Novartis Investigative Site
Moss, 1523, Norway
Novartis Investigative Site
Nesttun, 5221, Norway
Novartis Investigative Site
Oslo, 0303, Norway
Novartis Investigative Site
Oslo, 0424, Norway
Novartis Investigative Site
Sandefjord, 3211, Norway
Novartis Investigative Site
Skedsmokorset, 2020, Norway
Novartis Investigative Site
Stavanger, 4068, Norway
Novartis Investigative Site
Trondheim, 7011, Norway
Novartis Investigative Site
Tynset, 2501, Norway
Novartis Investigative Site
Tønsberg, 3116, Norway
Novartis Investigative Site
Bellavista, Lima region, CALLAO 02, Peru
Novartis Investigative Site
San Isidro, Lima region, 27, Peru
Novartis Investigative Site
San Martín de Porres, Lima region, 31, Peru
Novartis Investigative Site
Lima, LIMA 39, Peru
Novartis Investigative Site
Gdansk, 80-435, Poland
Novartis Investigative Site
Gdynia, 81-157, Poland
Novartis Investigative Site
Gdynia, 81-302, Poland
Novartis Investigative Site
Gdynia, 81-423, Poland
Novartis Investigative Site
Lublin, 20-538, Poland
Novartis Investigative Site
Ostrów Wielkopolski, 63-400, Poland
Novartis Investigative Site
Oława, 55-200, Poland
Novartis Investigative Site
Poznan, 60-375, Poland
Novartis Investigative Site
Poznan, 61-874, Poland
Novartis Investigative Site
Puławy, 24100, Poland
Novartis Investigative Site
Rumia, 84-230, Poland
Novartis Investigative Site
Skierniewice, 96-100, Poland
Novartis Investigative Site
Torun, 87-100, Poland
Novartis Investigative Site
Warsaw, 04-073, Poland
Novartis Investigative Site
Węgrów, 07-100, Poland
Novartis Investigative Site
Włocławek, 87-800, Poland
Novartis Investigative Site
Manatí, 00674, Puerto Rico
Novartis Investigative Site
Mayagüez, 00680, Puerto Rico
Novartis Investigative Site
Ponce, 00716, Puerto Rico
Novartis Investigative Site
Ponce, 00717, Puerto Rico
Novartis Investigative Site
San Juan, 00909, Puerto Rico
Novartis Investigative Site
San Juan, 00926, Puerto Rico
Novartis Investigative Site
San Juan, 00936-6528, Puerto Rico
Novartis Investigative Site
Piteşti, Argeş, 110438, Romania
Novartis Investigative Site
Bucharest, District 1, 010225, Romania
Novartis Investigative Site
Bucharest, District 1, Romania
Novartis Investigative Site
Bucharest, District 2, Romania
Novartis Investigative Site
Bucharest, District 4, 4204179, Romania
Novartis Investigative Site
Oradea, Jud Bihor, 410169, Romania
Novartis Investigative Site
Cluj-Napoca, Jud Cluj, 400015, Romania
Novartis Investigative Site
Iași, Jud Iasi, 700732, Romania
Novartis Investigative Site
Târgu Mureş, Jud Mures, 540043, Romania
Novartis Investigative Site
Constanța, Jud. Constanta, 900591, Romania
Novartis Investigative Site
Craiova, Jud. Dolj, 200497, Romania
Novartis Investigative Site
Iași, Jud. Iasi, 700111, Romania
Novartis Investigative Site
Târgu Mureş, Mureș County, 540124, Romania
Novartis Investigative Site
Tg Mures, Mureș County, 540136, Romania
Novartis Investigative Site
Brăila, ROM, 810249, Romania
Novartis Investigative Site
Timișoara, Timiș County, 300362, Romania
Novartis Investigative Site
Baia Mare, 430123, Romania
Novartis Investigative Site
Brasov, 500283, Romania
Novartis Investigative Site
Bucharest, 011728, Romania
Novartis Investigative Site
Bucharest, 011774, Romania
Novartis Investigative Site
Bucharest, 021659, Romania
Novartis Investigative Site
Cluj-Napoca, 400006, Romania
Novartis Investigative Site
Cluj-Napoca, 400347, Romania
Novartis Investigative Site
Craiova, 200642, Romania
Novartis Investigative Site
Oradea, 410169, Romania
Novartis Investigative Site
Piteşti, 110084, Romania
Novartis Investigative Site
Sibiu, 550371, Romania
Novartis Investigative Site
Târgu Mureş, 540096, Romania
Novartis Investigative Site
Târgu Mureş, 540136, Romania
Novartis Investigative Site
Târgu Mureş, 540142, Romania
Novartis Investigative Site
Timișoara, 300310, Romania
Novartis Investigative Site
Timișoara, 300736, Romania
Novartis Investigative Site
Chelyabinsk, 454000, Russia
Novartis Investigative Site
Chelyabinsk, 454047, Russia
Novartis Investigative Site
Chelyabinsk, 454048, Russia
Novartis Investigative Site
Izhevsk, 426063, Russia
Novartis Investigative Site
Kazan', 420012, Russia
Novartis Investigative Site
Kemerovo, 650029, Russia
Novartis Investigative Site
Kirov, 610027, Russia
Novartis Investigative Site
Kirov, 610035, Russia
Novartis Investigative Site
Krasnodar, 350086, Russia
Novartis Investigative Site
Moscow, 111539, Russia
Novartis Investigative Site
Moscow, 117198, Russia
Novartis Investigative Site
Moscow, 117556, Russia
Novartis Investigative Site
Moscow, 119881, Russia
Novartis Investigative Site
Moscow, 125284, Russia
Novartis Investigative Site
Moscow, 127018, Russia
Novartis Investigative Site
Moscow, 127473, Russia
Novartis Investigative Site
Novosibirsk, 630087, Russia
Novartis Investigative Site
Penza, 440067, Russia
Novartis Investigative Site
Perm, 614097, Russia
Novartis Investigative Site
Perm, 614107, Russia
Novartis Investigative Site
Petrozavodsk, 185019, Russia
Novartis Investigative Site
Ryazan, 390026, Russia
Novartis Investigative Site
Saint Petersburg, 190013, Russia
Novartis Investigative Site
Saint Petersburg, 192257, Russia
Novartis Investigative Site
Saint Petersburg, 193163, Russia
Novartis Investigative Site
Saint Petersburg, 194044, Russia
Novartis Investigative Site
Saint Petersburg, 194295, Russia
Novartis Investigative Site
Saint Petersburg, 195067, Russia
Novartis Investigative Site
Saint Petersburg, 196084, Russia
Novartis Investigative Site
Saint Petersburg, 197022, Russia
Novartis Investigative Site
Saint Petersburg, 197110, Russia
Novartis Investigative Site
Saint Petersburg, 197341, Russia
Novartis Investigative Site
Saint Petersburg, 199106, Russia
Novartis Investigative Site
Samara, 443070, Russia
Novartis Investigative Site
Samara, 443096, Russia
Novartis Investigative Site
Saratov, 410012, Russia
Novartis Investigative Site
Saratov, 410028, Russia
Novartis Investigative Site
Sestroretsk, 197706, Russia
Novartis Investigative Site
Smolensk, 214018, Russia
Novartis Investigative Site
Syktyvkar, 167981, Russia
Novartis Investigative Site
Tomsk, 634012, Russia
Novartis Investigative Site
Tyumen, 625026, Russia
Novartis Investigative Site
Vladimir, 600020, Russia
Novartis Investigative Site
Yaroslavl, 150047, Russia
Novartis Investigative Site
Yekaterinburg, 620028, Russia
Novartis Investigative Site
Yekaterinburg, 620102, Russia
Novartis Investigative Site
Yekaterinburg, 620109, Russia
Novartis Investigative Site
Yekaterinburg, 620137, Russia
Novartis Investigative Site
Belgrade, 11040, Serbia
Novartis Investigative Site
Kamenitz, 21204, Serbia
Novartis Investigative Site
Niš, 18000, Serbia
Novartis Investigative Site
Niška Banja, 18205, Serbia
Novartis Investigative Site
Bratislava, Slovak Republic, 826 06, Slovakia
Novartis Investigative Site
Brezno, Slovak Republic, 977 42, Slovakia
Novartis Investigative Site
Komárno, Slovak Republic, 94575, Slovakia
Novartis Investigative Site
Košice, Slovak Republic, 040 22, Slovakia
Novartis Investigative Site
Považská Bystrica, Slovak Republic, 017 01, Slovakia
Novartis Investigative Site
Prešov, Slovak Republic, 080 01, Slovakia
Novartis Investigative Site
Prešov, Slovak Republic, 08001, Slovakia
Novartis Investigative Site
Rimavská Sobota, Slovak Republic, 97901, Slovakia
Novartis Investigative Site
Svidník, Slovak Republic, 08901, Slovakia
Novartis Investigative Site
Veľký Krtíš, Slovak Republic, 990 01, Slovakia
Novartis Investigative Site
Banská Bystrica, 97401, Slovakia
Novartis Investigative Site
Bardejov, 085 01, Slovakia
Novartis Investigative Site
Bratislava, 81369, Slovakia
Novartis Investigative Site
Bratislava, 831 06, Slovakia
Novartis Investigative Site
Bratislava, 841 07, Slovakia
Novartis Investigative Site
Dubnica nad Váhom, 01841, Slovakia
Novartis Investigative Site
Dunajská Streda, 929 01, Slovakia
Novartis Investigative Site
Galanta, 92701, Slovakia
Novartis Investigative Site
Košice, 040 01, Slovakia
Novartis Investigative Site
Košice, 04001, Slovakia
Novartis Investigative Site
Levice, 934 01, Slovakia
Novartis Investigative Site
Lučenec, 984 01, Slovakia
Novartis Investigative Site
Lučenec, 98403, Slovakia
Novartis Investigative Site
Martin, 036 01, Slovakia
Novartis Investigative Site
Nitra, 949 01, Slovakia
Novartis Investigative Site
Nitra, 94901, Slovakia
Novartis Investigative Site
Nové Zámky, 940 01, Slovakia
Novartis Investigative Site
Nové Zámky, 94002, Slovakia
Novartis Investigative Site
Prešov, 081 01, Slovakia
Novartis Investigative Site
Trnava, 91702, Slovakia
Novartis Investigative Site
Žilina, 012 07, Slovakia
Novartis Investigative Site
Celje, 3000, Slovenia
Novartis Investigative Site
Golnik, 4204, Slovenia
Novartis Investigative Site
Ljubljana, 1000, Slovenia
Novartis Investigative Site
Durban, KwaZulu-Natal, 4052, South Africa
Novartis Investigative Site
Cape Town, Western Cape, 7405, South Africa
Novartis Investigative Site
Alberton, 1449, South Africa
Novartis Investigative Site
Bloemfontein, 9301, South Africa
Novartis Investigative Site
Cape Town, 7405, South Africa
Novartis Investigative Site
Cape Town, 7925, South Africa
Novartis Investigative Site
Centurion, 4001, South Africa
Novartis Investigative Site
Johannesburg, 2193, South Africa
Novartis Investigative Site
Kempton Park, 1620, South Africa
Novartis Investigative Site
Pretoria, 0002, South Africa
Novartis Investigative Site
Western Cape, 7130, South Africa
Novartis Investigative Site
Wŏnju, Gangwon-do, 26426, South Korea
Novartis Investigative Site
Suwon, Gyeonggi-do, 443380, South Korea
Novartis Investigative Site
Uijeongbu-si, Gyeonggi-do, 480-717, South Korea
Novartis Investigative Site
Daejeon, Korea, 35015, South Korea
Novartis Investigative Site
Seoul, Korea, 08308, South Korea
Novartis Investigative Site
Seoul, Seocho Gu, 06591, South Korea
Novartis Investigative Site
Busan, 49201, South Korea
Novartis Investigative Site
Busan, 602739, South Korea
Novartis Investigative Site
Busan, 612-896, South Korea
Novartis Investigative Site
Daegu, 705 718, South Korea
Novartis Investigative Site
Daegu, 705703, South Korea
Novartis Investigative Site
Gwangju, 61469, South Korea
Novartis Investigative Site
Seoul, 03722, South Korea
Novartis Investigative Site
Gothenburg, Västra Götaland County, SE-413 45, Sweden
Novartis Investigative Site
Borås, 506 30, Sweden
Novartis Investigative Site
Gothenburg, 416 85, Sweden
Novartis Investigative Site
Kristianstad, 291 85, Sweden
Novartis Investigative Site
Luleå, 972 33, Sweden
Novartis Investigative Site
Lund, 22142, Sweden
Novartis Investigative Site
Lund, 222 21, Sweden
Novartis Investigative Site
Malmo, 214 22, Sweden
Novartis Investigative Site
Mölndal, 431 80, Sweden
Novartis Investigative Site
Östersund, 831 83, Sweden
Novartis Investigative Site
Skanör, 239 33, Sweden
Novartis Investigative Site
Skellefteå, 931 86, Sweden
Novartis Investigative Site
Stockholm, 118 83, Sweden
Novartis Investigative Site
Stockholm, SE-111 35, Sweden
Novartis Investigative Site
Uddevalla, 451 50, Sweden
Novartis Investigative Site
Vällingby, 162 68, Sweden
Novartis Investigative Site
Västerås, 72189, Sweden
Novartis Investigative Site
Taichung, Taiwan ROC, 40201, Taiwan
Novartis Investigative Site
Taipei, Taiwan, ROC, 11217, Taiwan
Novartis Investigative Site
Changhua, 50006, Taiwan
Novartis Investigative Site
Kaohsiung City, 80756, Taiwan
Novartis Investigative Site
Kaohsiung City, 83301, Taiwan
Novartis Investigative Site
Taichung, 40447, Taiwan
Novartis Investigative Site
Tainan, 71004, Taiwan
Novartis Investigative Site
Taipei, 10002, Taiwan
Novartis Investigative Site
Taipei, 10449, Taiwan
Novartis Investigative Site
Taipei, 114, Taiwan
Novartis Investigative Site
Taipei, Taiwan
Novartis Investigative Site
Taoyuan District, 33305, Taiwan
Novartis Investigative Site
Yilan, 26058, Taiwan
Novartis Investigative Site
Eskişehir, Meselik, 26480, Turkey (Türkiye)
Novartis Investigative Site
Aydin, 09100, Turkey (Türkiye)
Novartis Investigative Site
Istanbul, 34304, Turkey (Türkiye)
Novartis Investigative Site
Izmir, 35040, Turkey (Türkiye)
Novartis Investigative Site
Izmir, 35340, Turkey (Türkiye)
Novartis Investigative Site
Kocaeli, 41380, Turkey (Türkiye)
Novartis Investigative Site
Mersin, 33079, Turkey (Türkiye)
Novartis Investigative Site
Sivas, 58140, Turkey (Türkiye)
Novartis Investigative Site
Basingstoke, Hampshire, RG24 9NA, United Kingdom
Novartis Investigative Site
Newport, Isle Of Wight, PO30 5TG, United Kingdom
Novartis Investigative Site
Salford, Manchester, M6 8HD, United Kingdom
Novartis Investigative Site
Whitby, North Yorkshire, Y021 1SD, United Kingdom
Novartis Investigative Site
Dundee, Perthshire, DD1 9SY, United Kingdom
Novartis Investigative Site
Axbridge, Somerset, BS26 2BJ, United Kingdom
Novartis Investigative Site
Taunton, Somerset, TA1 5DA, United Kingdom
Novartis Investigative Site
Cardiff, Wales, CF5 4AD, United Kingdom
Novartis Investigative Site
Barnet, EN5 3DJ, United Kingdom
Novartis Investigative Site
Berkshire, RG2 0TG, United Kingdom
Novartis Investigative Site
Birmingham, B15 2SQ, United Kingdom
Novartis Investigative Site
Birmingham, B15 2TH, United Kingdom
Novartis Investigative Site
Birmingham, B9 5SS, United Kingdom
Novartis Investigative Site
Cardiff, CF14 5GJ, United Kingdom
Novartis Investigative Site
Cheshire, CW11 1EQ, United Kingdom
Novartis Investigative Site
Chesterfield, S40 4AA, United Kingdom
Novartis Investigative Site
Chorley, PR7 7NA, United Kingdom
Novartis Investigative Site
Exeter, EX2 5DW, United Kingdom
Novartis Investigative Site
Glasgow, G20 0SP, United Kingdom
Novartis Investigative Site
Glasgow, G20 0XA, United Kingdom
Novartis Investigative Site
Glasgow, G51 4TF, United Kingdom
Novartis Investigative Site
Irvine, KA12 0AY, United Kingdom
Novartis Investigative Site
Leicester, LE3 9QP, United Kingdom
Novartis Investigative Site
Liverpool, L22 0LG, United Kingdom
Novartis Investigative Site
London, EC14 7BE, United Kingdom
Novartis Investigative Site
Manchester, M15 6SX, United Kingdom
Novartis Investigative Site
Newcastle upon Tyne, NE7 7DN, United Kingdom
Novartis Investigative Site
Newport, NP20 2UB, United Kingdom
Novartis Investigative Site
Norwich, NR4 7UY, United Kingdom
Novartis Investigative Site
Nottingham, NG5 1PB, United Kingdom
Novartis Investigative Site
Sheffield, S5 7AU, United Kingdom
Novartis Investigative Site
Wiltshire, SN15 2SB, United Kingdom
Novartis Investigative Site
Worcester, WR5 1DD, United Kingdom
Novartis Investigative Site
York, YO31 8HE, United Kingdom
Related Publications (18)
Woo J, Lu D, Lewandowski A, Xu H, Serrano P, Healey M, Yates DP, Beste MT, Libby P, Ridker PM, Steensma DP. Effects of IL-1beta inhibition on anemia and clonal hematopoiesis in the randomized CANTOS trial. Blood Adv. 2023 Dec 26;7(24):7471-7484. doi: 10.1182/bloodadvances.2023011578.
PMID: 37934948DERIVEDRidker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG. Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy. Eur Heart J. 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444.
PMID: 35943897DERIVEDSvensson EC, Madar A, Campbell CD, He Y, Sultan M, Healey ML, Xu H, D'Aco K, Fernandez A, Wache-Mainier C, Libby P, Ridker PM, Beste MT, Basson CT. TET2-Driven Clonal Hematopoiesis and Response to Canakinumab: An Exploratory Analysis of the CANTOS Randomized Clinical Trial. JAMA Cardiol. 2022 May 1;7(5):521-528. doi: 10.1001/jamacardio.2022.0386.
PMID: 35385050DERIVEDEverett BM, MacFadyen JG, Thuren T, Libby P, Glynn RJ, Ridker PM. Inhibition of Interleukin-1beta and Reduction in Atherothrombotic Cardiovascular Events in the CANTOS Trial. J Am Coll Cardiol. 2020 Oct 6;76(14):1660-1670. doi: 10.1016/j.jacc.2020.08.011.
PMID: 33004131DERIVEDSchieker M, Conaghan PG, Mindeholm L, Praestgaard J, Solomon DH, Scotti C, Gram H, Thuren T, Roubenoff R, Ridker PM. Effects of Interleukin-1beta Inhibition on Incident Hip and Knee Replacement : Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial. Ann Intern Med. 2020 Oct 6;173(7):509-515. doi: 10.7326/M20-0527. Epub 2020 Aug 4.
PMID: 32744862DERIVEDVallurupalli M, MacFadyen JG, Glynn RJ, Thuren T, Libby P, Berliner N, Ridker PM. Effects of Interleukin-1beta Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial. Ann Intern Med. 2020 Apr 21;172(8):523-532. doi: 10.7326/M19-2945. Epub 2020 Mar 24.
PMID: 32203978DERIVEDRothman AM, MacFadyen J, Thuren T, Webb A, Harrison DG, Guzik TJ, Libby P, Glynn RJ, Ridker PM. Effects of Interleukin-1beta Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk: A Secondary Analysis of CANTOS. Hypertension. 2020 Feb;75(2):477-482. doi: 10.1161/HYPERTENSIONAHA.119.13642. Epub 2019 Dec 30.
PMID: 31884854DERIVEDRidker PM, MacFadyen JG, Thuren T, Libby P. Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1beta inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis. Eur Heart J. 2020 Jun 14;41(23):2153-2163. doi: 10.1093/eurheartj/ehz542.
PMID: 31504417DERIVEDEverett BM, Cornel JH, Lainscak M, Anker SD, Abbate A, Thuren T, Libby P, Glynn RJ, Ridker PM. Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure. Circulation. 2019 Mar 5;139(10):1289-1299. doi: 10.1161/CIRCULATIONAHA.118.038010.
PMID: 30586730DERIVEDSolomon DH, Glynn RJ, MacFadyen JG, Libby P, Thuren T, Everett BM, Ridker PM. Relationship of Interleukin-1beta Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial. Ann Intern Med. 2018 Oct 16;169(8):535-542. doi: 10.7326/M18-1167. Epub 2018 Sep 18.
PMID: 30242335DERIVEDRidker PM, Libby P, MacFadyen JG, Thuren T, Ballantyne C, Fonseca F, Koenig W, Shimokawa H, Everett BM, Glynn RJ. Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Eur Heart J. 2018 Oct 7;39(38):3499-3507. doi: 10.1093/eurheartj/ehy310.
PMID: 30165610DERIVEDRidker PM, MacFadyen JG, Glynn RJ, Koenig W, Libby P, Everett BM, Lefkowitz M, Thuren T, Cornel JH. Inhibition of Interleukin-1beta by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease. J Am Coll Cardiol. 2018 May 29;71(21):2405-2414. doi: 10.1016/j.jacc.2018.03.490.
PMID: 29793629DERIVEDEverett BM, Donath MY, Pradhan AD, Thuren T, Pais P, Nicolau JC, Glynn RJ, Libby P, Ridker PM. Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes. J Am Coll Cardiol. 2018 May 29;71(21):2392-2401. doi: 10.1016/j.jacc.2018.03.002. Epub 2018 Mar 12.
PMID: 29544870DERIVEDRidker PM, MacFadyen JG, Everett BM, Libby P, Thuren T, Glynn RJ; CANTOS Trial Group. Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial. Lancet. 2018 Jan 27;391(10118):319-328. doi: 10.1016/S0140-6736(17)32814-3. Epub 2017 Nov 13.
PMID: 29146124DERIVEDRidker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ; CANTOS Trial Group. Effect of interleukin-1beta inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016/S0140-6736(17)32247-X. Epub 2017 Aug 27.
PMID: 28855077DERIVEDRidker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANTOS Trial Group. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27.
PMID: 28845751DERIVEDCanada JM, Fronk DT, Cei LF, Carbone S, Erdle CO, Abouzaki NA, Melchior RD, Thomas CS, Christopher S, Turlington JS, Trankle CR, Thurber CJ, Evans RK, Dixon DL, Van Tassell BW, Arena R, Abbate A. Usefulness of C-Reactive Protein Plasma Levels to Predict Exercise Intolerance in Patients With Chronic Systolic Heart Failure. Am J Cardiol. 2016 Jan 1;117(1):116-20. doi: 10.1016/j.amjcard.2015.10.020. Epub 2015 Oct 19.
PMID: 26546248DERIVEDRidker PM, Thuren T, Zalewski A, Libby P. Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J. 2011 Oct;162(4):597-605. doi: 10.1016/j.ahj.2011.06.012. Epub 2011 Sep 14.
PMID: 21982649DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Limitations and Caveats
Comparison across groups is no longer feasible in the Extension phase because all patients received canakinumab 150 mg. Beyond the primary endpoint, all p-values for the canakinumab 50 mg and 300 mg groups are to be considered nominal only.
Results Point of Contact
- Title
- Study Director
- Organization
- Novartis Pharmaceuticals
Study Officials
- STUDY DIRECTOR
Novartis Pharmaceuticals
Novartis Pharmaceuticals
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 29, 2011
First Posted
April 4, 2011
Study Start
April 11, 2011
Primary Completion
March 28, 2017
Study Completion
April 14, 2019
Last Updated
January 22, 2020
Results First Posted
January 22, 2020
Record last verified: 2020-01
Data Sharing
- IPD Sharing
- Will share
Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations. This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com